STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO2148Cytochrome B subunit; Cytochrome b subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of ubiquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis. The cytochrome b subunit contains two ubiquinol reactive sites: the oxidation (QP) site and the reduction (QN) site. (545 aa)    
Predicted Functional Partners:
SCO2149
Rieske iron-sulfur protein; Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis; Belongs to the Rieske iron-sulfur protein family.
 
 0.999
SCO2150
SC6G10.23c, qcrC, cytochrome C heme-binding subunit, len: aa; similar to many eg. TR:O69583 (EMBL:AL022602) proposed QcrC protein from Mycobacterium leprae (164 aa) fasta scores; opt: 368, z-score: 374.3, E(): 1.5e-13, (45.4% identity in 141 aa overlap). Contains two Pfam matches to entry PF00034 cytochrome_c, Cytochrome c and two Prosite matches to PS00190 Cytochrome c family heme-binding site signature. Also contains possible membrane spanning hydrophobic regions.
 
 0.999
SCO2151
SC6G10.24c, cox3, cytochrome c oxidase subunit III, len: 206aa; similar to many eg. SW:COX3_BACP3 caaC, cytochrome c oxidase subunit III from Bacillus PS3 (207 aa) fasta scores; opt: 397, z-score: 511.9, E(): 3.3e-21, (35.9% identity in 181 aa overlap). Contains Pfam match to entry PF00510 COX3, Cytochrome c oxidase subunit III.
 
 
 0.999
SCO2156
Putative cytochrome c oxidase subunit II; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity).
 
 
 0.999
SCO2155
Putative cytochrome c oxidase subunit I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).
 
 
 0.997
SCO7234
Cytochrome C oxidase polypeptide I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).
 
 
 0.996
SCO2154
Putative integral membrane protein; Part of cytochrome c oxidase, its function is unknown. Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
 
 
 0.986
SCO7235
Putative integral membrane protein; Part of cytochrome c oxidase, its function is unknown. Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
 
 
 0.985
SCO1763
SCI51.03, possible iron-sulphur protein (putative secreted protein), len: 131 aa; similar to part of many cytochrome B6-F complex iron-sulfur subunits from bacteria and chloroplasts e.g. SW:UCRI_CHLLT (EMBL:X73628), PetC, Chlorobium limicola F. sp. thiosulfatophilum iron-sulfur subunit (180 aa), fasta scores; opt: 198 z-score: 217.9 E(): 8.2e-05, 34.4% identity in 90 aa overlap. Similar to TR:Q9Z510 (EMBL:AL035591) Streptomyces coelicolor putative iron sulphur binding protein (141 aa) (36.6% identity in 131 aa overlap). Contains Pfam match to entry PF00355 Rieske, Rieske iron-sulfur pr [...]
 
 0.968
SCO6051
SC1B5.11c, probable iron-sulfur binding oxidoreductase, len: 513 aa; similar to e.g. ORDL_ECOLI P37906 escherichia coli. probable oxidoreductase (426 aa), fasta scores; opt: 303 z-score: 334.4 E(): 2.1e-11, 25.4% identity in 389 aa overlap. Contains PS00199 and PS00200 Rieske iron-sulfur protein signatures 1 and 2, and Pfam match to entry Rieske PF00355, Rieske iron-sulfur protein, score 49.39.
  
 0.962
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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