STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO2881SCE6.18, cvnC12, unknown, len: 117 aa. Similar to many proteins of undefined function from Streptomyces coelicolor e.g. TR:CAB71243 (EMBL:AL138598) SC1A2.05 (126 aa), fasta scores opt: 194 z-score: 251.3 E(): 1.4e-06 38.7% identity in 119 aa overlap and TR:Q9X834 (EMBL:AL049727) SC9B1.14C (119 aa), fasta scores opt: 192 z-score: 249.3 E(): 1.9e-06 37.9% identity in 124 aa overlap. (117 aa)    
Predicted Functional Partners:
SCO2880
Conserved hypothetical protein SCE6.17; SCE6.17, cvnB12, unknown, len: 140 aa. Similar to many proteins of undefined function from Streptomyces coelicolor e.g. TR:Q9X835 (EMBL:AL049727) SC9B1.15C (139 aa), fasta scores opt: 222 z-score: 297.5 E(): 3.9e-09 34.3% identity in 134 aa overlap and TR:CAB61281 (EMBL:AL132991) SCF55.11C (152 aa), fasta scores opt: 221 z-score: 295.6 E(): 4.9e-09 32.6% identity in 138 aa overlap. Contains a Pfam match to entry PF01860 DUF42, Protein of unknown function.
 
     0.958
SCO2879
SCE6.16, cvnA12, possible membrane protein, len: 551 aa. Similar to many Streptomyces coelicolor proteins e.g. TR:CAB59483 (EMBL:AL132648) putative integral membrane protein, SCI41.13C (541 aa), fasta scores opt: 449 z-score: 340.7 E(): 1.5e-11 27.5% identity in 564 aa overlap. Contains a possible hydrophobic membrane spanning region and coiled-coils between residues 120..140.
 
 
 0.950
SCO2882
SCE6.19, cvnD12, possible ATP/GTP-binding protein, len: 182 aa. Highly similar to many other ATP/GTP-binding proteins from Streptomyces coelicolor including: TR:CAB59480 (EMBL:AL132648) SCI41.10C (176 aa), fasta scores opt: 618 z-score: 748.9 E(): 0 58.4% identity in 166 aa overlap and TR:Q9X833 (EMBL:AL049727) SC9B1.13C (181 aa), fasta scores opt: 588 z-score: 712.9 E(): 2.8e-32 53.4% identity in 176 aa overlap. Contains a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop).
 
    0.871
SCO7463
SCBAC14E8.03, cvnA13, possible sensor histidine kinase, len: 400 aa; similar to TR:Q9L137 (EMBL:AL158061) Streptomyces coelicolor putative sensor histidine-kinase SC6D11.18c, 543 aa; fasta scores: pt: 500 Z-score: 444.9 bits: 91.6 E(): 3.3e-17; 32.591% identity in 359 aa overlap and to TR:Q9AJP4 (EMBL:AB044803) Streptomyces griseus ORF1, 543 aa; fasta scores: opt: 511 Z-score: 495.4 E(): 5.8e-20; 34.627% identity in 335 aa overlap. Contains Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase and possible N-terminal region signal peptide sequence.
 
 
 0.782
SCO2883
Putative cytochrome P450; SCE6.20, possible cytochrome P450, len: 410 aa. Highly similar to many other cytochrome P450 proteins from Streptomyces including: S. coelicolor TR:CAB61278 (EMBL:AL132991) SCF55.08C (420 aa), fasta scores opt: 710 z-score: 807.4 E():0 33.1% identity in 411 aa overlap and S. violaceus (S. venezuelae) TR:O87605 (EMBL:AF087022) cytochrome P450 monooxygenase, PikC (416 aa), fasta scores opt: 464 z-score: 529.1 E(): 4.8e-22 30.2% identity in 411 aa overlap. Also similar to the adjoining CDS SCE6.21 (408 aa), fasta scores opt: 257 z-score: 252.4 E(): 1.5e-08 26.5% [...]
 
   0.748
SCO6069
SC9B1.16c, cvnA6, possible large secreted protein, len: 877aa; similar to two neighbouring hypothetical proteins from Streptomyces coelicolor TR:O86525 (EMBL:AL031124) (1329 aa) fasta scores; opt: 1056, z-score: 919.5, E(): 0, (30.4% identity in 891 aa overlap) TR:O86522 (EMBL:AL031124) (1111 aa) fasta scores; opt: 804, z-score: 701.8, E(): 9e-32, (28.4% identity in 849 aa overlap). Contains possible N-terminal signal sequence.
 
 
 0.733
SCO6026
SC1C3.14c, probable fatty acid oxidation complex alpha-subunit, similar to many e.g. FADB_ECOLI (729 aa), fasta scores; opt: 782 z-score: 863.1 E(): 0, 29.8% identity in671 aa overlap. Contains Pfam match to entry ECH PF00378, Enoyl-CoA hydratase/isomerase, score 49.78.
  
 0.710
SCO6732
SC5F2A.15, possible fatty acid oxidative multifunctional enzyme, len: 726aa; similar to SW:FAOB_PSEFR fatty oxidation complex alpha subunit from Pseudomonas fragi (715 aa) fasta scores; opt: 1174, z-score: 1211.3, E(): 0, (33.2% identity in 717 aa overlap). Also similar to TR:O53872 (EMBL:AL022004) hypothetical protein from Mycobacterium tuberculosis (720 aa) fasta scores; opt: 3034, z-score: 3128.4, E(): 0, (64.3% identity in 717 aa overlap). Also similar to SC6A5.38 (EMBL:AL049485) possible fatty oxidation protein from Streptomyces coelicolor (733 aa) fasta scores; opt: 4069, z-score [...]
  
 0.710
SCO6789
SC6A5.38, possible fatty oxidation protein, len: 733aa; similar to many eg. SW:FADB_ECOLI FadB, a multifunctional protein from the Escherichia coli fadBA operon, encoding the fatty acid-oxidizing multienzyme complex (729 aa) fasta scores; opt: 1119, z-score: 1146.7, E(): 0, (32.3% identity in 691 aa overlap). Contains Pfam matches to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family and entry PF00725 3HCDH, 3-hydroxyacyl-CoA dehydrogenase and a Prosite match to PS00923 Aspartate and glutamate racemases signature 1.
  
 0.710
SCO7466
SCBAC14E8.06, cvnD13, possible ATP/GTP-binding protein, len: 176 aa; similar to TR:Q9XAE1 (EMBL:AL079356) Streptomyces coelicolor putative ATP/GTP-binding protein SC6G9.41c, 191 aa; fasta scores: opt: 615 Z-score: 755.2 bits: 146.4 E(): 1.7e-34; 55.172% identity in 174 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop).
 
    0.702
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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