STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO2946SCE59.05c, possible sugar transporter sugar-binding protein, len: 432 aa; similar to TR:CAB59588 (EMBL:AL132662) Streptomyces coelicolor putative sugar transporter sugar-binding protein SCF11.11, 422 aa; fasta scores: opt: 538 z-score: 581.0 E(): 6e-25; 27.0% identity in 429 aa overlap and to SW:MALX_STRPN (EMBL:L08611) Streptococcus pneumoniae maltose/maltodextrin-binding protein precursor MalX, 423 aa; fasta scores: opt: 299 z-score: 325.5 E(): 1e-10; 26.0% identity in 431 aa overlap. Contains Pfam match to entry PF01547 SBP_bacterial_1, Bacterial extracellular solute-binding protein [...] (432 aa)    
Predicted Functional Partners:
SCO2944
SCE59.03c, possible sugar transporter membrane protein, len: 281 aa; similar to TR:CAB59590 (EMBL:AL132662) Streptomyces coelicolor putative sugar transporter inner membrane protein SCF11.13, 285 aa; fasta scores: opt: 730 z-score: 883.7 E(): 0; 42.1% identity in 278 aa overlap and to TR:AAF11008 (EMBL:AE001988) Deinococcus radiodurans ABC transporter, permease protein, MalFG family DR1436, 283 aa; fasta scores: opt: 645 z-score: 781.7 E(): 0; 38.2% identity in 272 aa overlap. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane co [...]
 
 0.995
SCO2945
SCE59.04c, possible sugar transporter membrane protein, len: 316 aa; similar to TR:CAB59589 (EMBL:AL132662) Streptomyces coelicolor putative sugar transporter inner membrane protein SCF11.12, 302 aa; fasta scores: and to TR:CAB55533 (EMBL:AL117322) Streptomyces coelicolor putative binding-protein-dependent transport protein SCF1.13, 317 aa; fasta scores: opt: 527 z-score: 611.6 E(): 1.2e-26; 33.1% identity in 302 aa overlap. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component. Contains also possible hydrophobic membrane [...]
 
  0.995
SCO5233
Putative sugar transporter integral membrane protein; Part of the ABC transporter complex DasABC-MsiK involved in N,N'-diacetylchitobiose ((GlcNAc)2) uptake. Responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family.
 
 0.979
SCO5234
Putative sugar transporter integral membrane protein; Part of the ABC transporter complex DasABC-MsiK involved in N,N'-diacetylchitobiose ((GlcNAc)2) uptake. Responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family.
 
 0.932
SCO0532
SCF11.12, probable sugar transporter membrane protein, len: 302 aa; similar to TR:CAB55533 (EMBL:Y07706) Streptomyces coelicolor inner membrane protein MalF, 300 aa; fasta scores: opt: 493 z-score: 600.8 E(): 4.3e-26; 32.6% identity in 291 aa overlap. Contains a Pfam match to entry PF00528 BPD_transp, binding-protein-dependent transport systems inner membrane component and a prosite match to entry PS00402 binding-protein-dependent transport systems inner membrane component signature.
 
  0.926
SCO0533
SCF11.13, possible sugar transporter membrane protein, len: 285 aa; similar to TR:CAB46387 (EMBL:AL096743) Streptomyces coelicolor putative integral membrane transport protein MalG, 296 aa; fasta scores: opt: 538 z-score: 675.0 E(): 3.2e-30; 33.7% identity in 279 aa overlap. Contains Pfam match to entry PF00528 BPD_transp, binding-protein-dependent transport systems inner membrane component and prosite match to entry PS00402 binding-protein-dependent transport systems inner membrane component signature.
 
 0.926
SCO1707
SCI30A.28c, probable ABC sugar transporter, ATP-binding subunit, len: 445aa; similar to many eg. TR:AAD24578 (EMBL:AF126010) trehalose/maltose transport ATP-hydrolysing subunit from hyperthermophilic archaeon Thermococcus litoralis (372 aa) fasta scores; opt: 975, z-score: 1068.2, E(): 0, (50.1% identity in 335 aa overlap). Contains Pfam match to entry PF00005 ABC_tran, ABC transporter and Prosite matches to PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop).
  
 0.898
SCO4240
ABC transporter ATP-binding protein; Part of the ABC transporter complexes DasABC-MsiK and NgcEFG- MsiK involved in N,N'-diacetylchitobiose ((GlcNAc)2) uptake. Responsible for energy coupling to the transport system.
  
 0.898
SCO2943
SCE59.02c, probable sugar hydrolase, len: 545 aa; similar to TR:Q9ZH39 (EBML:AF072374) Pseudoalteromonas sp. S9 beta-N-acetylglucosaminidase ChiQ, 783 aa; fasta scores: opt: 1378 z-score: 1537.3 E(): 0; 41.6% identity in 512 aa overlap and to SW:HEX1_VIBFU (EMBL:U41417) Vibrio furnissii beta-hexosaminidase (EC 3.2.1.52) ExoI, 611 aa; fasta scores: opt: 1023 z-score: 1142.5 E(): 0; 40.0% identity in 487 aa overlap. Contains Pfam match to entry PF00728 Glyco_hydro_20, Glycosyl hydrolase family 20.
 
     0.813
SCO2941
Conserved hypothetical protein SCE56.05c; SCE56.05c, unknown, len: 773 aa; similar to C-terminal region of TR:Q9VYQ2 (EMBL:AE003488) Drosophila melanogaster CG2779 protein, 1612 aa; fasta scores: opt: 651 Z-score: 464.7 E(): 3e-18; 31.405% identity in 847 aa overlap. High content in proline, glycine and alanine. Contains Pfam matches to entries PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains and PF01799 fer2_2, [2Fe-2S] binding domain and match to Prosite entry PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature.
       0.739
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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