STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3042SCE34.23, possible transcriptional regulator, len: 396 aa; similar to TR:O86796 (EMBL:AL031317) Streptomyces coelicolor putative transcriptional regulator SC6G4.33, 360 aa; fasta scores: opt: 792 z-score: 875.9 E(): 0; 43.3% identity in 363 aa overlap, to TR:O68907 (EMBL:AF05830) Streptomyces roseofulvus FrnA, 770 aa; fasta scores: opt: 686 z-score: 739.2 E(): 0; 41.3% identity in 283 aa overlap, to Streptomyces coelicolor SCE34.26, 507 aa; fasta scores: opt: 709 z-score: 659.1 E(): 3.4e-31; 36.4% identity in 357 aa overlap, StE34.25, 507 aa; fasta scores: opt: 671 z-score: 624.0 E(): [...] (396 aa)    
Predicted Functional Partners:
SCO1748
2SCI34.01c, probable expression regulator (fragment), len: >159 aa; highly similar to metallothionein-like proteins e.g. TR:Q9WX50 (EMBL:AB012145) Streptomyces lividans MrnA encoding metallothionein-like domain exhibiting repressor function against protease expression, 315 aa; fasta scores: opt: 507 z-score: 589.0 E(): 2.3e-25; 98.8% identity in 81 aa overlap; SCI11.37c, probable expression regulator, partial CDS, len: >272 aa; highly similar to metallothionein-like proteins e.g. Streptomyces lividans CDS (EMBL:AB012145) exhibiting repressor function against protease expression (315 aa [...]
      
 0.879
SCO2578
Putative membrane protein; SCC123.16c, possible membrane protein, len: 592 aa. Contains a possible membrane spanning hydrophobic domain. The protein is rich in the amino acid Gln and has a notable repeat region with 6x QQ(G/Y) between residues 53..84.
      
 0.859
SCO2579
Putative nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
     
 0.663
SCO3043
SCE34.24, conserved hypothetical protein, len: 472 aa; similar to TR:O68907 (EMBL:AF05830) Streptomyces roseofulvus FrnA, 770 aa; fasta scores: opt: 1249 z-score: 1391.4 E(): 0; 52.0% identity in 429 aa overlap, to Streptomyces coelicolor SCE34.26, 507 aa; fasta scores: opt: 2161 z-score: 2203.4 E(): 0; 70.9% identity in 471 aa overlap, to SCE34.23, 404 aa; fasta scores: opt: 666 z-score: 682.6 E(): 1.6e-32; 38.0% identity in 324 aa overlap, to SCE34.27 (fragment), >356 aa; fasta scores: opt: 659 z-score: 676.4 E(): 3.7e-32; 39.9% identity in 348 aa overlap and to SCE35.25, 507 aa; fas [...]
 
   
0.663
SCO3045
SCE34.26, putative secreted protein, len: 507 aa; similar to TR:O68907 (EMBL:AF05830) Streptomyces roseofulvus FrnA, 770 aa; fasta scores: opt: 1350 z-score: 1461.9 E(): 0; 55.1% identity in 430 aa overlap, to Streptomyces coelicolor SCE34.24, 472 aa; fasta scores: opt: 2161 z-score: 2145.7 E(): 0; 70.9% identity in 471 aa overlap, to SCE34.25, 507 aa; fasta scores: opt: 739 z-score: 735.6 E(): 0; 31.9% identity in 508 aa overlap, to SCE34.23, 404 aa; fasta scores: opt: 709 z-score: 707.2 E(): 7e-34; 36.4% identity in 357 aa overlap and to SCE34.27 (fragment), >356 aa; fasta scores: op [...]
 
    
0.637
SCO3048
SCBAC19G2.03c, possible membrane protein, len: 397aa: similar to TR:O69850 (EMBL:AL023702) putative transcriptional regulator from Streptomyces coelicolor (366 aa) fasta scores; opt: 615, Z-score: 578.6, 34.694% identity (37.072% ungapped) in 343 aa overlap. Contains possible membrane-spanning hydrophobic region. Also has region of similarity with adjacent CDS SCBAC19F3.02.
 
   
0.611
SCO2568
SCC123.06c, possible DNA-binding protein, len: 355 aa. Similar to Mycobacterium tuberculosis TR:P71728 (EMBL:Z81368) hypothetical 30.5 KD protein (297 aa), opt: 271 z-score: 260.6 E(): 4e-07 36.3% identity in 292 aa overlap. Also similar in parts to Bacillus subtilis SW:CME1_BACSU (EMBL:L15202) ComE operon protein 1, required for the binding and uptake of transforming DNA (205 aa), fasta scores opt: 295 z-score: 284.5 E(): 1.9e-08 32.2% identity in 180 aa overlap. Contains a Pfam match to entry PF00633 HHH, Helix-hairpin-helix motif and a possible membrane spanning hydrophobic domain.
 
     0.595
SCO3039
SCE34.20c, probable nucleotide phosphorylase, len: 360 aa; similar to SW:MPG1_YEAST (EMBL:U19608) Saccharomyces cerevisiae mannose-1-phosphate guanyltransferase (EC 2.7.7.13) Mpg1, 361 aa; fasta scores: opt: 570 z-score: 625.6 E(): 2.2e-27; 30.8% identity in 347 aa overlap. Contains Pfam matches to entries PF00483 NTP_transferase, Nucleotidyl transferase and 3x PF00132 hexapep, Bacterial transferase hexapeptide (four repeats).
 
     0.583
SCO3009
Conserved hypothetical protein; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
  
     0.563
SCO3884
SCH24.06, conserved hypothetical protein, len: 170 aa; previously sequenced as TR:O54595 (EMBL:Y16311) Streptomyces coelicolor jag-like protein (170 aa). Similar to SW:JAG_BACSU (EMBL:Z14225), jag, Bacillus subtilis SpoIIIJ associated protein (208 aa), fasta scores; opt: 231 z-score: 268.4 E(): 1.1e-07, 31.7% identity in 139 aa overlap, and other jag homologs e.g. TR:O53598 (EMBL:AL021426) Mycobacterium tuberculosis hypothetical protein (187 aa) (62.7% identity in 169 aa overlap).
  
     0.563
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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