STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3045SCE34.26, putative secreted protein, len: 507 aa; similar to TR:O68907 (EMBL:AF05830) Streptomyces roseofulvus FrnA, 770 aa; fasta scores: opt: 1350 z-score: 1461.9 E(): 0; 55.1% identity in 430 aa overlap, to Streptomyces coelicolor SCE34.24, 472 aa; fasta scores: opt: 2161 z-score: 2145.7 E(): 0; 70.9% identity in 471 aa overlap, to SCE34.25, 507 aa; fasta scores: opt: 739 z-score: 735.6 E(): 0; 31.9% identity in 508 aa overlap, to SCE34.23, 404 aa; fasta scores: opt: 709 z-score: 707.2 E(): 7e-34; 36.4% identity in 357 aa overlap and to SCE34.27 (fragment), >356 aa; fasta scores: op [...] (507 aa)    
Predicted Functional Partners:
SCO3869
SCH18.06, probable WD-40 repeat protein, len: 1676 aa; C-terminal domain identical to previously sequenced TR:Q9ZEM4 (EMBL:AJ131817) Streptomyces coelicolor WD-40 repeat protein WdpA, 1049 aa; fasta scores: opt: 7025 z-score: 5917.8 E(): 0; 99.8% identity in 1049 aa overlap. Contains 13x Pfam matches to entry PF00400 WD40, WD domain, G-beta repeat, 9x matches to Prosite entry PS00678 Trp-Asp (WD) repeats signature and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop).
      
 0.851
SCO3870
SCH18.07c, possible integral membrane protein, len: 66 aa. Contains possible hydrophobic membrane spanning regions.
      
 0.851
SCO3974
Hypothetical protein; SCBAC25E3.11c, unknown, len: 321aa: contains Pfam match to entry PF02810 SEC-C, SEC-C motif.
      
 0.851
SCO5333
SCBAC5H2.02c, conserved hypothetical protein, len: 301 aa; similar to TR:Q9RU61 (EMBL:AE001997) Deinococcus radiodurans conserved hypothetical protein DR1533, 299 aa; fasta scores: opt: 496 z-score: 583.0 E(): 6.7e-25; 46.3% identity in 298 aa overlap. Contains Pfam match to entry PF02182 G9a, Domain of unknown function.
      
 0.798
SCO3046
SCE34.27, conserved hypothetical protein (fragment), len: >357 aa; similar to TR:O68907 (EMBL:AF05830) Streptomyces roseofulvus FrnA, 770 aa; fasta scores: opt: 676 z-score: 755.5 E(): 0; 43.3% identity in 293 aa overlap, to Streptomyces coelicolor SCE34.25, 507 aa; fasta scores: opt: 1210 z-score: 1247.7 E(): 0; 51.5% identity in 359 aa overlap, to SCE34.24, 472 aa; fasta scores: opt: 659 z-score: 681.3 E(): 1.9e-32; 39.9% identity in 348 aa overlap, to SCE34.26, 507 aa; fasta scores: opt: 643 z-score: 664.4 E(): 1.7e-31; 39.5% identity in 354 aa overlap and to SCE34.23, 404 aa; fasta [...]
 
   
0.708
SCO3044
SCE34.25, conserved hypothetical protein, len: 507 aa; similar to TR:O68907 (EMBL:AF05830) Streptomyces roseofulvus FrnA, 770 aa; fasta scores: opt: 711 z-score: 770.7 E(): 0; 33.9% identity in 508 aa overlap, to Streptomyces coelicolor SCE34.27 (fagment), >356 aa; fasta scores: opt: 1210 z-score: 1128.7 E(): 0; 51.5% identity in 359 aa overlap, to SCE34.26, 507 aa; fasta scores: opt: 739 z-score: 689.6 E(): 6.7e-33; 33.1% identity in 508 aa overlap, to SCE34.23, 404 aa; fasta scores: opt: 671 z-score: 628.0 E(): 1.8e-29; 33.2% identity in 365 aa overlap and to SCE34.24, 472 aa; fasta [...]
 
   
0.679
SCO5334
Hypothetical protein SCBAC5H2.03c; SCBAC5H2.03c, unknown, len: 104 aa. Highly hydrophilic. High content in arginine and serine amino acid residues.
      
 0.667
SCO3042
SCE34.23, possible transcriptional regulator, len: 396 aa; similar to TR:O86796 (EMBL:AL031317) Streptomyces coelicolor putative transcriptional regulator SC6G4.33, 360 aa; fasta scores: opt: 792 z-score: 875.9 E(): 0; 43.3% identity in 363 aa overlap, to TR:O68907 (EMBL:AF05830) Streptomyces roseofulvus FrnA, 770 aa; fasta scores: opt: 686 z-score: 739.2 E(): 0; 41.3% identity in 283 aa overlap, to Streptomyces coelicolor SCE34.26, 507 aa; fasta scores: opt: 709 z-score: 659.1 E(): 3.4e-31; 36.4% identity in 357 aa overlap, StE34.25, 507 aa; fasta scores: opt: 671 z-score: 624.0 E(): [...]
 
    
0.637
SCO3009
Conserved hypothetical protein; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
  
     0.544
SCO3047
SCBAC19G2.02, possible membrane protein, len: 524aa: similar to many eg. neighbouring gene TR:Q9KZK3 (EMBL:AL353862) SCE34.23 putative transcriptional regulator (396 aa) fasta scores; opt: 631, Z-score: 610.7, 36.011% identity (38.235% ungapped) in 361 aa overlap and TR:O68907 (EMBL:AF058302) FrnA from polyketide antibiotic frenolicin biosynthetic cluster of Streptomyces roseofulvus (770 aa) fasta scores; opt: 482, Z-score: 464.5, 28.387% identity (32.195% ungapped) in 465 aa overlap. Contains possible membrane-spanning hydrophobic region. Also has region of similarity with adjacent CD [...]
 
   
0.532
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.