STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3088Hypothetical protein SCE29c; SCE25.29c, doubtful CDS, function unknown, len: 81 aa. Hig content in alanine and glycine amino acid residues. (81 aa)    
Predicted Functional Partners:
SCO3285
SCE15.02c, large glycine/alanine rich protein, len: 1772aa.
      
 0.645
SCO6958
Putative membrane protein; SC6F7.11, possible membrane protein, len: 105 aa. Similar to two potassium-efflux system proteins from Rhizobium meliloti: TR:Q52983(EMBL:X93358) K-efflux system protein, PhaF (92 aa), fasta scores opt: 160 z-score: 228.2 E(): 2.8e-05 34.9% identity in 86 aa overlap and SW:PHF2_RHIME(EMBL:L37353) PhaF2 (123 aa), fasta scores opt: 166 z-score: 234.3 E(): 1.3e-05 37.5% identity in 96 aa overlap. Contains N-terminal membrane spanning hydrophobic domains.
      
 0.645
SCO3089
SCE25.30 probable ABC transporter ATP-binding protein, len: 256 aa; similar to TR:CAB81857 (EMBL:AL16169) Streptomyces coelicolor putative ABC transporter ATP-binding protein SCD40A.12c, 246 aa; fasta scores: opt: 922 z-score: 1039.0 E(): 0; 58.4% identity in 238 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature.
       0.540
SCO3286
SCE15.03, putative secreted protein, len: 677 aa; weak similarity to SW:YQIK_ECOLI hypothetical protein from Escherichia coli (553 aa) fasta scores; opt: 542, z-score: 501.2, E(): 1.3e-20, (27.0% identity in 504 aa overlap). Contains possible N-terminal region signal peptide sequence also contains a highly hidrophilic central part of the protein.
      
 0.519
SCO4262
Hypothetical protein SCD49.03; SCD49.03, unknown, len: 115 aa; doubtful CDS. Contains a TTA leucine codon, possible target for bldA regulation and high %G+C (70.43).
      
 0.510
SCO4721
50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.
      
 0.510
SCO5013
SCK15.15, possible secreted protein, len: 198 aa. Contains possible N-terminal region signal peptide sequence. High content in alanine amino acid residues.
      
 0.510
SCO5166
SCP8.29c, possible helicase, len: 879 aa; N-terminal domain similar to SW:RHLE_ECOLI (EMBL:L02123) Escherichia coli putative ATP-dependent RNA helicase RhlE, 454 aa; fasta scores: opt: 884 z-score: 704.8 E(): 8.6e-32; 37.2% identity in 444 aa overlap. Contains Pfam matches to entries PF00270 DEAD, DEAD/DEAH box helicase and PF00271 helicase_C, Helicases conserved C-terminal domain and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00039 DEAD-box subfamily ATP-dependent helicases signature. Also contains three sets of different repeats: 10x RU1: RRTRK, 4x [...]
      
 0.510
SCO4295
SCD95A.28, scoF4, cold shock protein, len: 67 aa; highly similar to TR:AAD49327 (EMBL:AF162937) Streptomyces coelicolor A3(2) cold shock protein F40, 67 aa; fasta scores: opt: 317 z-score: 454.8 E(): 7.2e-18; 70.3% identity in 64 aa overlap. Contains Pfam match to entry PF00313 CSD, 'Cold-shock' DNA-binding domain and match to Prosite entry PS00352 'Cold-shock' DNA-binding domain signature.
      
 0.483
SCO6808
SC1A2.17c, possible ArsR-family transcriptional regulator, len: 120 aa. Similar to several regulators including: Streptomyces coelicolor TR:Q9X8X8 (EMBL:AL078610) putative transcriptional regulator, SCH35.28C (122 aa), fasta scores opt: 297 z-score: 392.7 E(): 1.8e-14 49.4% identity in 87 aa overlap and Mycobacterium tuberculosis TR:P71941 (EMBL:Z80225) putative transcriptional regulator (126 aa), fasta scores opt: 262 z-score: 348.0 E(): 5.6e-12 38.1% identity in 113 aa overlap. Contains a Pfam match to entry PF01022 HTH_5, Bacterial regulatory protein, arsR family with the putative h [...]
      
 0.483
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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