STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3546SCH5.09c, possible small lipoprotein, len: 196aa; Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site and probable N-terminal signal sequence. Contains probable coiled-coil from 104 to 141 (38 residues), max score: 1.630, (probability 1.00). (196 aa)    
Predicted Functional Partners:
SCO3545
SCH5.08c, possible transferase, len: 505 aa; limited similarity to many proteins of undefined function e.g. TR:O27384 (EMBL:AE000896) methyltransferase related protein (196 aa) fasta scores; opt: 162, z-score: 186.2, E(): 0.0046, (28.9% identity in 152 aa overlap). Contains PS00092 N-6 Adenine-specific DNA methylases signature; Belongs to the methyltransferase superfamily.
       0.787
SCO3544
SCH5.07c, putative membrane protein, len: 132 aa. Contains possible hydrophobic membrane spanning regions.
       0.774
SCO3547
Putative pyrophosphate synthase; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.
       0.741
SCO3548
SCH5.11c, probable anti-sigma factor, len: 143 aa; similar to many e.g. SW:RSBW_BACSU RsbW, anti-sigma B factor from Bacillus subtilis (160 aa) fasta scores; opt: 153, z-score: 198.9, E(): 0.00089, (28.7% identity in 136 aa overlap) and SW:SP22_BACSU SpoIIAB, anti-sigma F factor, sporulation protein, from Bacillus subtilis (146 aa) fasta scores; opt: 125, z-score: 165.8, E(): 0.063, (29.2% identity in 137 aa overlap).
       0.659
SCO3549
Putative anti-sigma factor antagonist; Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B (By similarity).
       0.636
SCO3543
Probable DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing [...]
       0.556
SCO3550
SCH5.13, possible helicase, len: 815 aa; similar to many e.g. SW:YPRA_BACSU hypothetical helicase from Bacillus subtilis (749 aa) fasta scores; opt: 1616, z-score: 1799.2, E(): 0, (37.7% identity in 735 aa overlap). Also similar to TR:O06359 (EMBL:Z95436) hypothetical protein from Mycobacterium tuberculosis (771 aa) fasta scores; opt: 2550, z-score: 2840.4, E(): 0, (52.5% identity in 774 aa overlap). Contains Pfam match to entry PF00271 helicase_C, Helicases conserved C-terminal domain, score 35.50, E-value 1.2e-06.
       0.413
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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