node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCO0499 | SCO1473 | gene:17758082 | gene:17759059 | SCF34.18, possible formyltransferase, len: 315 aa; similar to TR:Q50378 (EMBL:U10425), FxbA, Mycobacterium smegmatis putative formyltransferase required for exochelin biosynthesis (360 aa), fasta scores; opt: 942 z-score: 1102.4 E(): 0, 49.5% identity in 309 aa overlap. Also similar to many methionyl-tRNA formyltransferases e.g. SW:FMT_PSEAE (EMBL:AF073952), Fmt, Pseudomonas aeruginosa methionyl-tRNA formyltransferase (314 aa) (30.3% identity in 307 aa overlap). Contains Pfam match to entry PF00551 formyl_transf, Formyl transferase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.910 |
SCO0499 | SCO1657 | gene:17758082 | gene:17759250 | SCF34.18, possible formyltransferase, len: 315 aa; similar to TR:Q50378 (EMBL:U10425), FxbA, Mycobacterium smegmatis putative formyltransferase required for exochelin biosynthesis (360 aa), fasta scores; opt: 942 z-score: 1102.4 E(): 0, 49.5% identity in 309 aa overlap. Also similar to many methionyl-tRNA formyltransferases e.g. SW:FMT_PSEAE (EMBL:AF073952), Fmt, Pseudomonas aeruginosa methionyl-tRNA formyltransferase (314 aa) (30.3% identity in 307 aa overlap). Contains Pfam match to entry PF00551 formyl_transf, Formyl transferase. | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.925 |
SCO0499 | SCO2571 | gene:17758082 | gene:17760173 | SCF34.18, possible formyltransferase, len: 315 aa; similar to TR:Q50378 (EMBL:U10425), FxbA, Mycobacterium smegmatis putative formyltransferase required for exochelin biosynthesis (360 aa), fasta scores; opt: 942 z-score: 1102.4 E(): 0, 49.5% identity in 309 aa overlap. Also similar to many methionyl-tRNA formyltransferases e.g. SW:FMT_PSEAE (EMBL:AF073952), Fmt, Pseudomonas aeruginosa methionyl-tRNA formyltransferase (314 aa) (30.3% identity in 307 aa overlap). Contains Pfam match to entry PF00551 formyl_transf, Formyl transferase. | SCC123.09c, leuS, leucyl-tRNA synthetase (EC 6.1.1.4) len: 966 aa. Highly similar to many leucyl-tRNA synthetases including: Bacillus subtilis SW:SYL_BACSU(EMBL:M88581) (804 aa), fasta scores opt: 508 z-score: 575.2 E(): 1.2e-24 48.1% identity in 941 aa overlap and Mycobacterium leprae SW:SYL_MYCLE(EMBL:Y14967) (972 aa), fasta scores opt: 3887 z-score: 4430.5 E():0 60.1% identity in 977 aa overlap. Contains a Prosite hit to PS00178 Amino-acyl-transfer RNA synthetases class-I signature and a Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V). | 0.425 |
SCO0499 | SCO3792 | gene:17758082 | gene:17761416 | SCF34.18, possible formyltransferase, len: 315 aa; similar to TR:Q50378 (EMBL:U10425), FxbA, Mycobacterium smegmatis putative formyltransferase required for exochelin biosynthesis (360 aa), fasta scores; opt: 942 z-score: 1102.4 E(): 0, 49.5% identity in 309 aa overlap. Also similar to many methionyl-tRNA formyltransferases e.g. SW:FMT_PSEAE (EMBL:AF073952), Fmt, Pseudomonas aeruginosa methionyl-tRNA formyltransferase (314 aa) (30.3% identity in 307 aa overlap). Contains Pfam match to entry PF00551 formyl_transf, Formyl transferase. | Putative methionyl tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.913 |
SCO1294 | SCO1657 | gene:17758877 | gene:17759250 | SCBAC36F5.05c, possible cystathionine gamma-synthase, len: 407 aa; similar to SW:METB_HAEIN (EMBL:U32694) Haemophilus influenzae cystathionine gamma-synthase (EC 4.2.99.9) MetB or HI0086, 369 aa; fasta scores: opt: 625 Z-score: 685.3 bits: 135.6 E(): 1.5e-30; 34.127% identity in 378 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme and match to Prosite entry PS01050 Uncharacterized protein family UPF0031 signature 2. | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.985 |
SCO1294 | SCO3792 | gene:17758877 | gene:17761416 | SCBAC36F5.05c, possible cystathionine gamma-synthase, len: 407 aa; similar to SW:METB_HAEIN (EMBL:U32694) Haemophilus influenzae cystathionine gamma-synthase (EC 4.2.99.9) MetB or HI0086, 369 aa; fasta scores: opt: 625 Z-score: 685.3 bits: 135.6 E(): 1.5e-30; 34.127% identity in 378 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme and match to Prosite entry PS01050 Uncharacterized protein family UPF0031 signature 2. | Putative methionyl tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.915 |
SCO1294 | SCO3920 | gene:17758877 | gene:17761547 | SCBAC36F5.05c, possible cystathionine gamma-synthase, len: 407 aa; similar to SW:METB_HAEIN (EMBL:U32694) Haemophilus influenzae cystathionine gamma-synthase (EC 4.2.99.9) MetB or HI0086, 369 aa; fasta scores: opt: 625 Z-score: 685.3 bits: 135.6 E(): 1.5e-30; 34.127% identity in 378 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme and match to Prosite entry PS01050 Uncharacterized protein family UPF0031 signature 2. | SCQ11.03c, cysA, probable cystathionine/methionine gamma-synthase/lyase, len: 392 aa; previously sequenced as SW:CYSA_STRCO (EMBL:U37580), cysA, S.coelicolor putative cystathionine gamma-lyase (392 aa). Similar to many e.g. SW:MEGL_PSEPU (EMBL:D88554), mdeA, Pseudomonas putida methionine gamma-lyase (398 aa), fasta scores; opt: 608 z-score: 653.6 E(): 4.5e-29, 36.9% identity in 404 aa overlap. Highly similar to TR:Q53668 (EMBL:X91393) Streptomyces antibioticus hypothetical protein found upstream of the abaB gene (232 aa) (87.1% identity in 232 aa overlap). Contains Pfam match to PF0105 [...] | 0.926 |
SCO1473 | SCO0499 | gene:17759059 | gene:17758082 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | SCF34.18, possible formyltransferase, len: 315 aa; similar to TR:Q50378 (EMBL:U10425), FxbA, Mycobacterium smegmatis putative formyltransferase required for exochelin biosynthesis (360 aa), fasta scores; opt: 942 z-score: 1102.4 E(): 0, 49.5% identity in 309 aa overlap. Also similar to many methionyl-tRNA formyltransferases e.g. SW:FMT_PSEAE (EMBL:AF073952), Fmt, Pseudomonas aeruginosa methionyl-tRNA formyltransferase (314 aa) (30.3% identity in 307 aa overlap). Contains Pfam match to entry PF00551 formyl_transf, Formyl transferase. | 0.910 |
SCO1473 | SCO1657 | gene:17759059 | gene:17759250 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.925 |
SCO1473 | SCO2076 | gene:17759059 | gene:17759674 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Putative isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. | 0.636 |
SCO1473 | SCO3792 | gene:17759059 | gene:17761416 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Putative methionyl tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.913 |
SCO1657 | SCO0499 | gene:17759250 | gene:17758082 | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | SCF34.18, possible formyltransferase, len: 315 aa; similar to TR:Q50378 (EMBL:U10425), FxbA, Mycobacterium smegmatis putative formyltransferase required for exochelin biosynthesis (360 aa), fasta scores; opt: 942 z-score: 1102.4 E(): 0, 49.5% identity in 309 aa overlap. Also similar to many methionyl-tRNA formyltransferases e.g. SW:FMT_PSEAE (EMBL:AF073952), Fmt, Pseudomonas aeruginosa methionyl-tRNA formyltransferase (314 aa) (30.3% identity in 307 aa overlap). Contains Pfam match to entry PF00551 formyl_transf, Formyl transferase. | 0.925 |
SCO1657 | SCO1294 | gene:17759250 | gene:17758877 | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | SCBAC36F5.05c, possible cystathionine gamma-synthase, len: 407 aa; similar to SW:METB_HAEIN (EMBL:U32694) Haemophilus influenzae cystathionine gamma-synthase (EC 4.2.99.9) MetB or HI0086, 369 aa; fasta scores: opt: 625 Z-score: 685.3 bits: 135.6 E(): 1.5e-30; 34.127% identity in 378 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme and match to Prosite entry PS01050 Uncharacterized protein family UPF0031 signature 2. | 0.985 |
SCO1657 | SCO1473 | gene:17759250 | gene:17759059 | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.925 |
SCO1657 | SCO2571 | gene:17759250 | gene:17760173 | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | SCC123.09c, leuS, leucyl-tRNA synthetase (EC 6.1.1.4) len: 966 aa. Highly similar to many leucyl-tRNA synthetases including: Bacillus subtilis SW:SYL_BACSU(EMBL:M88581) (804 aa), fasta scores opt: 508 z-score: 575.2 E(): 1.2e-24 48.1% identity in 941 aa overlap and Mycobacterium leprae SW:SYL_MYCLE(EMBL:Y14967) (972 aa), fasta scores opt: 3887 z-score: 4430.5 E():0 60.1% identity in 977 aa overlap. Contains a Prosite hit to PS00178 Amino-acyl-transfer RNA synthetases class-I signature and a Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V). | 0.595 |
SCO1657 | SCO3792 | gene:17759250 | gene:17761416 | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Putative methionyl tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.921 |
SCO1657 | SCO3920 | gene:17759250 | gene:17761547 | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | SCQ11.03c, cysA, probable cystathionine/methionine gamma-synthase/lyase, len: 392 aa; previously sequenced as SW:CYSA_STRCO (EMBL:U37580), cysA, S.coelicolor putative cystathionine gamma-lyase (392 aa). Similar to many e.g. SW:MEGL_PSEPU (EMBL:D88554), mdeA, Pseudomonas putida methionine gamma-lyase (398 aa), fasta scores; opt: 608 z-score: 653.6 E(): 4.5e-29, 36.9% identity in 404 aa overlap. Highly similar to TR:Q53668 (EMBL:X91393) Streptomyces antibioticus hypothetical protein found upstream of the abaB gene (232 aa) (87.1% identity in 232 aa overlap). Contains Pfam match to PF0105 [...] | 0.981 |
SCO1657 | SCO5547 | gene:17759250 | gene:17763199 | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). | 0.617 |
SCO2076 | SCO1473 | gene:17759674 | gene:17759059 | Putative isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.636 |
SCO2076 | SCO2571 | gene:17759674 | gene:17760173 | Putative isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. | SCC123.09c, leuS, leucyl-tRNA synthetase (EC 6.1.1.4) len: 966 aa. Highly similar to many leucyl-tRNA synthetases including: Bacillus subtilis SW:SYL_BACSU(EMBL:M88581) (804 aa), fasta scores opt: 508 z-score: 575.2 E(): 1.2e-24 48.1% identity in 941 aa overlap and Mycobacterium leprae SW:SYL_MYCLE(EMBL:Y14967) (972 aa), fasta scores opt: 3887 z-score: 4430.5 E():0 60.1% identity in 977 aa overlap. Contains a Prosite hit to PS00178 Amino-acyl-transfer RNA synthetases class-I signature and a Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V). | 0.998 |