STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3925SCQ11.08, probable transcriptional regulator, len: 241 aa; similar to many transcriptional regulators e.g. TR:Q43992 (EMBL:L05770), pobR, Acinetobacter calcoaceticus ADP1 transcriptional activator regulating expression of p-hydroxybenzoate hydroxylase (PobA) (271 aa), fasta scores; opt: 223 z-score: 262.9 E(): 2.6e-07, 25.9% identity in 239 aa overlap. Also similar to TR:O88025 (EMBL:AL031107) S.coelicolor probable transcriptional regulator (264 aa) (26.4% identity in 239 aa overlap). Contains probable helix-turn-helix motif at aa 19-40 (Score 1331, +3.72 SD) and possible hydrophobic m [...] (241 aa)    
Predicted Functional Partners:
SCO3922
SCQ11.05c, possible membrane protein, len: 125 aa; previously sequenced as SW:YPT3_STRCO (EMBL:U37580) hypothetical 15.9 kD protein in ptpA 5' region (148 aa), with different putative start codon. Start codon position is suggested here by GC frameplot analysis. Similar to others from mycobacteria and Bacillus subtilis e.g. TR:O07729 (EMBL:Z97193) Mycobacterium tuberculosis possible membrane protein (134 aa) (42.9% identity in 126 aa overlap).
     
 0.900
SCO2935
SCE19A.35c, probable transcriptional regulator, len: 220 aa; similar to many e.g. SW:ICLR_ECOLI (EMBL:M31761), IclR, Escherichia coli acetate operon repressor (274 aa), fasta scores; opt: 206 z-score: 234.8 E(): 9.6e-06, 29.2% identity in 154 aa overlap. Similar to TR:O05148 (EMBL:U89712), hppR, Rhodococcus globerulus putative regulator of 3-(3-hydroxyphenyl)propionic acid catabolic pathway (206 aa) (44.8% identity in 174 aa overlap). Contains probable helix-turn-helix motif at aa 27-48 (Score 1663, +4.85 SD).
  
   
 0.786
SCO3926
SCQ11.09, ssgA, probable regulator, len: 136 aa; highly similar to TR:P95753 (EMBL:D50051), SsgA, Streptomyces griseus protein associated with sporulation and cell division (136 aa), fasta scores; opt: 715 z-score: 896.6 E(): 0, 77.9% identity in 136 aa overlap and similar to others from S.coelicolor e.g. SC5F2A.05c (EMBL:AL049587) possible regulator (138 aa) (35.7% identity in 115 aa overlap) and SC5H1.03 (EMBL:AL049863) possible regulator (142 aa) (2.5% identity in 114 aa overlap), both annotated by similarity to Streptomyces griseus SsgA. The start codon was selected by similarity t [...]
     
 0.763
SCO3918
SCQ11.01c, hypothetical protein, partial CDS, len: >95 aa; unknown function, previously sequenced as TR:Q53870 (EMBL:U37580), S.coelicolor hypothetical protein ORF5 downstream of phosphotyrosine protein phosphatase (159 aa). Weak similarity to the N-terminus of TR:O69888 (EMBL:AL023797) Streptomyces coelicolor hypothetical protein (172 aa), fasta scores; opt: 158 z-score: 206.4 E(): 0.00036, 46.2% identity in 65 aa overlap. Continues as SCH24.40c in cosmid H24 (EMBL:AL049826); SCH24.40c, hypothetical protein, partial CDS, len: >96 aa; unknown function, highly similar to TR:Q53870 (EMBL [...]
 
   
 0.749
SCO1872
SCI39.19, probable IclR-family transcriptional regulator, len: 257 aa; similar to SW:ICLR_ECOLI (EMBL:M31761) Escherichia coli acetate operon repressor IclR, 274 aa; fasta scores: opt: 413 Z-score: 491.6 bits: 98.6 E(): 8.7e-20;31.855% identity in 248 aa overlap and to TR:Q9RDE7 (EMBL:AL136503) Streptomyces coelicolor putative IclR-family transcriptional regulator SCC77.11, 265aa; fasta scores: opt: 766 Z-score: 904.5 bits: 175.0 E(): 8.6e-43; 52.846% identity in 246 aa overlap. Contains Pfam match to entry PF01614 IclR, Bacterial transcriptional regulator and possible helix-turn-helix [...]
  
     0.732
SCO0345
SCF41.04c, probable IclR family regulator (putative secreted protein), len: 260 aa. Similar to many e.g. Agrobacterium tumefaciens TR:AAD43987 (EMBL:U59485) AttJ (275 aa), fasta scores: opt: 354 z-score: 406.3 E(): 2.8e-15 31.6% identity in 237 aa overlap and Streptomyces coelicolor TR:CAB45040 (EMBL:AL078635) putative transcriptional regulator (248 aa), fasta scores: opt: 333 z-score: 383.3 E(): 5.3e-14 32.3% identity in 248 aa overlap. Contains a Pfam match to entry PF01614 IclR.
  
     0.717
SCO2544
SCC77.11, possible IclR-family transcriptional regulator, len: 265 aa. Similar to many other IclR-family regulators including: Escherichia coli SW:ICLR_ECOLI (EMBL:M31761) acetate operon repressor IclR (274 aa), fasta scores opt: 368 z-score: 447.5 E(): 1.5e-17 33.1% identity in 263 aa overlap and Erwinia carotovora subsp. carotovora TR:AAD50647 (EMBL:AF135396) regulator of virulence KdgR (263 aa), fasta scores opt: 326 z-score: 397.5 E(): 9.4e-15 29.7% identity in 239 aa overlap. Contains a possible N-terminal helix-turn-helix motif, situated between residues 36..57 (+4.94 SD) and a P [...]
  
     0.713
SCO2440
SCC24.11c, probable transcriptional regulator, len: 257 aa; similar to SW:KDGR_ECOLI (EMBL:AE000277) Escherichia coli transcriptional regulator KdgR, 263 aa; fasta scores: opt: 446 z-score: 510.4 E(): 5.4e-21; 32.1% identity in 249 aa overlap. Contains Pfam match to entry PF01614 IclR, Bacterial transcriptional regulator.
  
     0.699
SCO7778
SC5E9.26, possible transcriptional regulator, len: 255 aa; similar to many e.g. SW:P15360 (GYLR_STRCO) glycerol operon regulatory protein from Streptomyces coelicolor (254 aa) fasta scores; opt: 217, z-score: 260.0, E(): 5.1e-07, 28.1% identity in 249 aa overlap and TR:O88025 (EMBL:AL031107) putative transcriptional regulator from Streptomyces coelicolor (264 aa) fasta scores; opt: 462, z-score: 543.0, E(): 9e-23, 40.5% identity in 242 aa overlap. Contains Pfam match to entry PF01614 IclR, Bacterial transcriptional regulator.
  
     0.698
SCO4989
2SCK36.12, probable IclR-family transcriptional regulatory protein, len: 254 aa; similar to SW:KDGR_ECOLI (EMBL:AE000277) Escherichia coli transcriptional regulator KdgR, 263 aa; fasta scores: opt: 420 Z-score: 488.7 bits: 98.0 E(): 1.3e-19; 30.992% identity in 242 aa overlap. Contains Pfam match to entry PF01614 IclR, Bacterial transcriptional regulator and possible helix-turn-helix motif at residues 20..41 (+3.12 SD).
  
     0.693
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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