STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO40422SCD60.08c, putative membrane protein, len: 204 aa; similar to TR:O07202 (EMBL:Z96072) Mycobacterium tuberculosis hypothetical 22.7 kDa protein MTCY05A6.21, 216 aa; fasta scores: opt: 193 z-score: 226.9 E(): 4.5e-05; 31.3% identity in 192 aa overlap. Contains possible hydrophobic membrane spanning region. (204 aa)    
Predicted Functional Partners:
SCO4043
2SCD60.09c, conserved hypothetical protein, len: 98 aa; similar to TR:O05823 (EMBL:Z95208) Mycobacterium tuberculosis hypothetical 12.0 kDa protein MTCY27.05c, 105 aa; fasta scores: opt: 419 z-score: 582.4 E(): 7e-25; 62.2% identity in 98 aa overlap.
 
     0.797
SCO2314
SCC53.05, possible integral membrane protein, len: 289 aa; contains possible membrane-spanning hydrophobic regions. Also contains Gly/Pro/Gln-rich region 160-220aa.
  
     0.636
SCO1101
2SCG4.17, possible integral membrane protein, len: 311 aa; similar to TR:Q9XAS1 (EMBL:AL078618) Streptomyces coelicolor putative integral membrane protein SC10A7.04, 312 aa; fasta scores: opt: 1123 z-score: 1310.0 E(): 0; 56.4% identity in 305 aa overlap. Contains possible hydrophobic membrane spanning regions.
  
     0.611
SCO1753
2SCI34.06, possible integral membrane protein, len: 340 aa. Contains Pfam match to entry PF01569 PAP2, PAP2 superfamily and possible hydrophobic membrane spanning regions. Also presents high content of alanine, arginine, leucine and proline amino acid residues.
  
     0.559
SCO4840
SC5G8.08, possible secreted protein, len: 339aa; N-terminal similar to many eg. TR:Q45633 (EMBL:L13418) maltose permease from Bacillus stearothermophilus (314 aa) fasta scores; opt: 155, z-score: 191.9, E(): 0.0031, 31.5% identity in 127 aa overlap. Contains a possible cleavable N-terminal signal sequence.
  
     0.556
SCO1672
Hypothetical protein; SCI52.14c, unknown, len: 267 aa. Contains 6x degenerate repeat unit:(T/G)(D/E)LD.
  
     0.551
SCO2059
SC4G6.28c, possible membrane protein, len: 238aa; Contains possible membrane spanning hydrophobic regions.
  
     0.528
SCO4579
SCD16A.04, possible integral membrane protein, len: 312aa; similar to others e.g. TR:O32910 (EMBL:AL008609) hypothetical protein from Mycobacterium leprae (316 aa) fasta scores; opt: 405, z-score: 470.7, E(): 6.9e-19, (32.7% identity in 324 aa overlap) and TR:O86628 (EMBL:AL031155) putative integral membrane protein from Streptomyces coelicolor (309 aa) fasta scores; opt: 222, z-score: 261.4, E(): 3.1e-07, (31.0% identity in 310 aa overlap). Contains possible membrane spanning hydrophobic regions.
  
     0.513
SCO3115
Hypothetical protein SCE41.24c; SCE41.24c, unknown, len: 889 aa. High content in alanine, glycine and proline amino acid residues. Contains 20x degenerate repeat: (G/P/A/N)P(G/P/A).
  
     0.506
SCO3676
SCH35.48c, possible integral membrane protein, len: 350aa; Contains possible membrane spanning hydrophobic regions in the C-terminal half and a hydrophobic N-terminal half.
  
     0.499
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.