STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO4108SCD17.12, probable peptidase, len: 347 aa. Similar to several Streptomyces coelicolor putative peptidases e.g. TR:CAB39706 (EMBL; AL049485) SC6A5.22 (312 aa), fasta scores opt: 570 z-score: 526.9 E(): 5.4e-22 37.1% identity in 315 aa overlap and TR:CAB40868 (EMBL; AL049628) SCE94.19C (228 aa), fasta scores opt: 460 z-score: 429.8 E(): 1.4e-16 40.1% identity in 217 aa overlap. Contains a Pfam match to entry PF01551 Peptidase_M37, an alanine rich region between residues 163..207 and a probable coiled coil between residues 149..219 (probability 1.00). (347 aa)    
Predicted Functional Partners:
SCO4109
SCD17.13, possible oxidoreductase, partial CDS, len: >136 aa. Similar to several including: Streptomyces fradiae TR:AAD41821 (EMBL; AF147704) NDP-Hexose 2,3-Enoyl reductase TYLCII (329 aa), fasta scores opt: 251 z-score: 325.2 E(): 9.3e-11 41.9% identity in 124 aa overlap and Saccharopolyspora erythraea (Streptomyces erythraeus) TR:O33936 (EMBL; U77454)EryBII (333 aa), fasta scores opt: 245 z-score: 317.5 E(): 2.5e-10 39.3% identity in 135 aa overlap; SCD17A.01, possible oxidoreductase (fragment), len: >218 aa; similar to TR:Q9RJC4 (EMBL:AL133171) Streptomyces coelicolor putative aldo/ [...]
       0.763
SCO5029
SCK7.02, possible secreted protein, len: 238 aa; similar to C-terminal region of TR:CAB93446 (EMBL:AL357591) Streptomyces coelicolor hypothetical 16.0 kDa protein SCC53.17, 154 aa; fasta scores: opt: 477 z-score: 484.5 E(): 1.6e-19; 64.4% identity in 101 aa overlap. Contains possible N-terminal region signal peptide sequence and possible coiled-coil region at aprox. residues 82..123.
     
 0.665
SCO3901
SCH24.23, probable secreted penicillin-binding protein, len: 795 aa; similar to many e.g. SW:PBPF_BACSU (EMBL:Y14083), PbpF, Bacillus subtilis penicillin-binding protein 1A (714 aa), fasta scores; opt: 439 z-score: 369.7 E(): 2.8e-13, 31.2% identity in 683 aa overlap. Contains hydrophobic, possible membrane-spanning region at N-terminus. Contains Pfam matches to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain, score 49.60, E-value 2.8e-11 and entry PF00912 Transglycosyl, Transglycosylase, score 172.40, E-value 7.3e-48. Contains PS00017 ATP/GTP-binding sit [...]
  
   
 0.655
SCO5487
Conserved hypothetical protein SC2A11.21c; SC2A11.21c, unknown, len: 242 aa; some similarity in C-terminus to enterobacterial ampD genes e.g. AMPD_ECOLI AMPD protein (183 aa), fasta scores; opt: 210 z-score: 212.6 E(): 0.00014, 31.5% identity in 149 aa overlapand Enterobacter cloacae TR:Q46957 (EMBL:U40785) anhydro-n-acetylmuramyl-tripeptide amidase (187 aa), fasta scores; opt: 207 z-score: 192.0 E(): 0.0019, 31.6% identity in 155 aa overlap.
      
 0.648
SCO2897
SCE6.34, probable secreted penicillin-binding protein, len: 756 aa. Similar to many including: Bacillus subtilis SW:PBPD_BACSU(EMBL:U11882) penicillin-binding protein 4 precursor (624 aa), fasta scores opt: 550 z-score: 456.8 E(): 5.5e-18 28.1% identity in 572 aa overlap and Helicobacter pylori TR:O25319(EMBL:AE000573) penicillin-binding protein 1A (659 aa), fasta scores opt: 750 z-score: 619.0 E(): 5.1e-27 31.9% identity in 605 aa overlap. Contains Pfam matches to entries PF00912 Transglycosyl, Transglycosylase and PF00905 Transpeptidase, Penicillin binding protein transpeptidase doma [...]
  
   
 0.609
SCO5039
SCK7.12, possible penicillin-binding protein, len: 773 aa; similar to TR:CAB88838 (EMBL:AL353832) Streptomyces coelicolor probable penicillin-binding protein SCE6.34, 756 aa; fasta scores: opt: 1080 z-score: 911.6 E(): 0; 46.0% identity in 733 aa overlap and to SW:PBPD_BACSU (EMBL:U11882) Bacillus subtilis penicillin-binding protein 4 precursor PbpD, 624 aa; fasta scores: opt: 513 z-score: 438.2 E(): 6.1e-17; 28.7% identity in 582 aa overlap. Contains Pfam matches to entries PF00912 Transglycosyl, Transglycosylase and PF00905 Transpeptidase, Penicillin binding protein transpeptidase do [...]
  
   
 0.606
SCO3580
SCH66.01, partial CDS, possible transpeptidase, len: >366 aa; similar to the C-terminal region of many penicillin-binding transpeptidases eg. SW:PBPD_BACSU penicillin-binding protein 4 from Bacillus subtilis (624 aa) fasta scores; opt: 298, z-score: 300.3, E(): 2.1e-09, (32.0% identity in 228 aa overlap). Contains Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain, score 3.70, E-value 1.6e-08; SCH17.14, probable penicillin-binding protein, partial CDS, len: >427 aa; similar to many e.g. TR:P72351 (EMBL:S82044), Pon1, Mycobacterium leprae penici [...]
  
     0.579
SCO3098
SCE41.07c, possible secreted protein, len: 341 aa; similar to TR:O53879 (EMBL:AL022004) Mycobacterium tuberculosis hypothetical 40.0 kDa protein MTV043.60c, 407 aa; fasta scores: opt: 443 z-score: 346.0 E(): 9.1e-12; 33.3% identity in 234 aa overlap. Contains Pfam match to entry PF01476 PG_binding_2, Putative peptidoglycan binding domain and high content in serine and glycine amino acid residues. Also contains a possible N-terminal region signal peptide sequence.
 
  
 0.564
SCO3150
Hypothetical protein; SCE87.01c, unknown, partial CDS, len: > 329 aa. Similar in parts to Mycobacterium tuberculosis TR:O05594 (EMBL:Z94752) hypothetical 38.1 KD protein (362 aa), fasta scores opt: 365 z-score: 372.3 E(): 2.3e-13 34.1% identity in 232 aa overlap and Bacillus subtilis SW:YABE_BACSU (EMBL:D26185) hypothetical 47.7 KD protein (437 aa), fasta scores opt: 315 z-score: 321.5 E(): 1.5e-10 29.2% identity in 233 aa overlap; SCE66.29c, unknown, partial CDS, len: >165aa; similar to TR:O05594 (EMBL:Z94752) hypothetical protein from Mycobacterium tuberculosis (362 aa) fasta scores; [...]
  
  
 0.557
SCO5660
SC6A9.07, probable secreted peptidase, len: 386 aa; similar to e.g. DAC_STRSQ D-alanyl-D-alanine carboxypeptidase precursor (406 aa), fasta scores; oopt: 544 z-score: 500.9 E(): 1.2e-20, 33.2% identity in 365 aa overlap. Contains N-terminal signal sequence and PS00017 ATP /GTP-binding site motif A (P-loop).
      
 0.518
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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