STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO4350SCD19.05c, possible integrase, len: 475 aa; highly similar to TR:Q9RAJ3 (EMBL:AJ250372) Mycobacterium sp. GP1 putative integrase IntM, 451 aa; fasta scores: opt: 2152 z-score: 2497.3 E(): 0; 72.8% identity in 441 aa overlap; Belongs to the 'phage' integrase family. (450 aa)    
Predicted Functional Partners:
SCO4348
SCD19.03c, hypothetical protein, len: 723 aa; similar to some plasmid derived hypothetical proteins, e.g. TR:O85873 (EMBL:AF079317) Sphingomonas aromaticivorans hypothetical 81.3 kDa protein (plasmid pNL1), 741 aa; fasta scores: opt: 421 z-score: 478.1 E(): 4e-19; 29.7% identity in 758 aa overlap.
       0.875
SCO4349
SCD19.04c, hypothetical protein, len: 571 aa; similar to some plasmid derived hypothetical proteins, e.g. TR:O85872 (EMBL:AF079317) Sphingomonas aromaticivorans hypothetical 65.3 kDa protein (plasmid pNL1), 595 aa; fasta scores: opt: 344 z-score: 399.6 E(): 9.4e-15; 26.7% identity in 561 aa overlap. Contains two TTA leucine codons, possible targets for bldA regulation.
       0.875
SCO4347
Hypothetical protein SCD19.02c; SCD19.02c, unknown, len: 142 aa. High content in alanine, arginine and leucine amino acid residues.
       0.825
SCO4351
SCD19.06, probable DNA invertase, len: 170 aa; similar to SW:DNIV_BPP1 (EMBL:X01828) Bacteriophage P1 DNA-invertase (site-specific recombinase) Cin, 186 aa; fasta scores: opt: 471 z-score: 560.8 E(): 9.9e-24; 48.8% identity in 170 aa overlap. Contains Pfam match to entry PF00239 recombinase, Site-specific recombinases.
  
  
 0.522
SCO3010
SCE33.12c, hypothetical protein, len: 315 aa; similar to TR:O05887 (EMBL:Z95121) hypothetical 22.5 kD protein MTCY20B11.17c, 213 aa; fasta scores: opt: 189 z-score: 191.8 E(): 0.0032; 36.8% identity in 228 aa overlap.
   
    0.497
SCO1514
Adenine phosphoribosiltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
   
    0.468
SCO1950
Hypothetical protein; Involved in cell division and chromosome segregation (By similarity). Involved in sporulation. May coordinate the cessation of aerial hyphae growth and subsequent chromosome segregation and/or septation. Required for expression of the ParB partioning protein during sporogenesis. Activates its own transcription and represses WhiB. Binds with low affinity to its own promoter and to the Parp2 sporulation-specific promoter. Also binds directly to the RNA polymerase sigma factor WhiG, leading to inhibition of WhiG-dependent transcription in a dose-dependent manner ; Be [...]
   
    0.442
SCO5214
SC7E4.11, hypothetical protein, len: 271 aa; similar to TR:O05872 (EMBL:Z95121) Mycobacterium tuberculosis hypothetical 27.6 kD protein MTCY20B11.01c, 252 aa; fasta scores: opt: 383 z-score: 460.8 E(): 3.4e-18; 39.6% identity in 283 aa overlap; Belongs to the SOS response-associated peptidase family.
   
    0.442
SCO4346
Hypothetical protein; SCD19.01c, unknown(fragment), len: >119 aa. Contains two TTA leucine codons, possible targets for bldA regulation; SCD12A.29c, unknown (fragment), len: > 282 aa.
       0.425
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.