STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO4438SCD6.16c, possible integral membrane protein, len: 625 aa; similar to TR:Q9KXI6 (EMBL:AL357591) Streptomyces coelicolor putative integral membrane protein SCC53.25, 551 aa; fasta scores: opt: 1266 Z-score: 1316.1 bits: 253.5 E(): 1.1e-65; 42.430% identity in 502 aa overlap. Contains possible hydrophobic membrane spanning regions. (625 aa)    
Predicted Functional Partners:
SCO4437
SCD6.15c, possible sodium-coupled permease, len: 527 aa; similar to TR:P74252 (EMBL:D90913) Synechocystis sp. sodium-coupled permease, 512 aa; fasta scores: opt: 451 z-score: 531.6 E(): 3.8e-22; 26.3% identity in 510 aa overlap. Contains Pfam match to entry PF00474 SSF, Sodium:solute symporter family and possible hydrophobic membrane spanning regions; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
     
 0.940
SCO4442
SCD6.20, hypothetical protein, len: 63 aa; similar to many other S. coelicolor hypothetical proteins, e.g. TR:CAB62714 (EMBL:AL133423) Streptomyces coelicolor hypothetical 6.9 kD protein SC4A7.10, 65 aa; fasta scores: opt: 159 z-score: 242.8 E(): 4.6e-06; 50.9% identity in 55 aa overlap.
     
 0.912
SCO4439
SCD6.17c, possible D-alanyl-D-alanine carboxypeptidase, len: 832 aa; similar to TR:O54201 (EMBL:AJ001743) Streptomyces clavuligerus Pbp2 protein (penicillin binding protein PbpA), 696 aa; fasta scores: opt: 955 z-score: 744.1 E(): 0; 37.0% identity in 757 aa overlap. Contains Pfam match to entry PF00768 Peptidase_S11, D-alanyl-D-alanine carboxypeptidase and high content in alanine, aspartic acid and glycine amino acid residues. Contains degenerate repeats: 2X (G/A)GAAPDSGSG(T/A)DATXXXPAPD(T/A) KPDQEPDADSEPAPDAQAASSRDGDAD.
 
  
 0.863
SCO4441
SCD6.19, possible DNA-binding protein, len: 295 aa; similar to many other S. coelicolor hypothetical proteins, e.g. TR:Q9X8K0 (EMBL:AL049841) Streptomyces coelicolor hypothetical 30.9 kD protein SCE9.28c, 274 aa; fasta scores: opt: 717 z-score: 834.5 E(): 0; 42.6% identity in 263 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and a possible helix-turn-helix motif at residues 37..58 (+5.84 SD).
     
 0.782
SCO4440
SCD6.18, hypothetical protein, len: 252 aa; similar to TR:Q9X7M7 (EMBL:AL049587) Streptomyces coelicolor putative integral membrane protein SC5F2A.04, 302 aa; fasta scores: opt: 228 z-score: 237.1 E(): 9.5e-06; 32.6% identity in 224 aa overlap.
  
  
 0.773
SCO2335
SCC53.26c, possible integral membrane protein, len: 761 aa; contains possible membrane-spanning hydrophobic regions. Regions similar to many eg. TR:CAB90881 (EMBL:AL355752) putative integral membrane protein from Streptomyces coelicolor (287 aa) fasta scores; opt: 627, z-score: 671.4, E(): 6.3e-30, 41.0% identity in 290 aa overlap.
 
   
 0.753
SCO1608
Hypothetical protein SCI35.30c; SCI35.30c, unknown, len: 237 aa; start uncertain, may be considerably further upstream.
  
     0.688
SCO1941
SCC54.01c, partial CDS, possible intergral membrane protein, len: >183aa; contains possible membrane spanning hydrophobic regions; SCC22.23c, partial CDS, possible integral membrane protein, len: >178aa; forms the C-terminal portion of TR:CAB38131 (EMBL:AL035591) partial CDS, possible integral membrane protein on the end of cosmid C54 from Streptomyces coelicolor.
  
     0.687
SCO4515
Putative membrane protein; SCD35.22c, hypothetical protein, len: 401 aa; similar to TR:Q9XD98 (EMBL:AF106004) Streptomyces coelicolor hypothetical 27.5 kD protein, 249 aa; fasta scores: opt: 190 z-score: 190.8 E(): 0.0034; 26.8% identity in 190 aa overlap and to TR:Q9F3G6 (EMBL:AL392175) Streptomyces coelicolor putative membrane protein 2SCD4.05, 474 aa; fasta scores: opt: 583 Z-score: 556.4 E(): 2.3e-23; 36.422% identity in 313 aa overlap. Contains possible hydrophobic membrane spanning regions and also possible colied-coil region ar aprox. residues 104..127.
  
     0.659
SCO4400
SCD10.32, possible membrane protein, len: 531 aa. Contains possible hydrophobic membrane spanning region and high content in alanine, glycine and proline amino acid residues. Also high G+C content (79.03%) and a 3x degenerate repeat unit: GGR.
  
     0.652
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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