STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO4441SCD6.19, possible DNA-binding protein, len: 295 aa; similar to many other S. coelicolor hypothetical proteins, e.g. TR:Q9X8K0 (EMBL:AL049841) Streptomyces coelicolor hypothetical 30.9 kD protein SCE9.28c, 274 aa; fasta scores: opt: 717 z-score: 834.5 E(): 0; 42.6% identity in 263 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and a possible helix-turn-helix motif at residues 37..58 (+5.84 SD). (295 aa)    
Predicted Functional Partners:
SCO4442
SCD6.20, hypothetical protein, len: 63 aa; similar to many other S. coelicolor hypothetical proteins, e.g. TR:CAB62714 (EMBL:AL133423) Streptomyces coelicolor hypothetical 6.9 kD protein SC4A7.10, 65 aa; fasta scores: opt: 159 z-score: 242.8 E(): 4.6e-06; 50.9% identity in 55 aa overlap.
 
   
 0.964
SCO4440
SCD6.18, hypothetical protein, len: 252 aa; similar to TR:Q9X7M7 (EMBL:AL049587) Streptomyces coelicolor putative integral membrane protein SC5F2A.04, 302 aa; fasta scores: opt: 228 z-score: 237.1 E(): 9.5e-06; 32.6% identity in 224 aa overlap.
 
   
 0.786
SCO4438
SCD6.16c, possible integral membrane protein, len: 625 aa; similar to TR:Q9KXI6 (EMBL:AL357591) Streptomyces coelicolor putative integral membrane protein SCC53.25, 551 aa; fasta scores: opt: 1266 Z-score: 1316.1 bits: 253.5 E(): 1.1e-65; 42.430% identity in 502 aa overlap. Contains possible hydrophobic membrane spanning regions.
     
 0.782
SCO0703
SCF42.13, possible regulator, len: 75 aa. Identical to the previously published Streptomyces coelicolor TR:Q53896 (EMBL:X60316) pleiotropic antibiotic regulatory locus AbaA, OrfD (75 aa), fasta scores opt: 507 z-score: 699.1 E(): 1.5e-31 98.7% identity in 75 aa overlap. Also highly similar to Streptomyces coelicolor TR:Q9X8K3 (EMBL:AL049841) putative regulator SCE9.31c (83 aa), fasta scores opt: 308 z-score: 431.8 E(): 1.2e-16 63.6% identity in 77 aa overlap.
 
     0.778
SCO3424
SCE9.31c, possible regulator, len: 83 aa; similar to TR:Q53896 (EMBL:X60316), abaA, Streptomyces coelicolor ORFD from AbaA regulatory locus for antibiotic production (75 aa), fasta scores; opt: 307 z-score: 422.3 E(): 3.4e-16, 64.9% identity in 74 aa overlap and to TR:Q53842 (EMBL:U28930), BldB, S.coelicolor developmental protein (98 aa) (41.8% identity in 67 aa overlap).
 
     0.772
SCO1978
SC3C9.13c, possible AbaA-like protein, len: 91 aa; similar to TR:Q9F3E1 (EMBL:AL450289) Streptomyces coelicolor putative AbaA-like protein SC2H2.14, 89 aa; fasta scores: opt: 371 Z-score: 479.1 bits: 93.2 E(): 4.5e-19; 69.863% identity in 73 aa overlap and to TR:Q53896 (EMBL:X60316) Streptomyces coelicolor AbaA gene (putative regulator) SCF42.13, 75 aa; fasta scores: opt: 220 Z-score: 293.4 bits: 58.6 E(): 9.9e-09; 50.000% identity in 74 aa overlap.
 
     0.768
SCO6607
Conserved hypothetical protein SC1F3.04; SC1F3.04, unknown, len: 261 aa; similar to many Streptomyces coelicolor e.g. upstream gene SC1F2.03c,E(): 0, 48.8% identity in 260 aa overlap.
  
     0.767
SCO7404
Conserved hypothetical protein SC10G8.32c; SC10G8.32c, unknown, len: 263 aa. Highly similar to a number of proteins of undefined function from Streptomyces coelicolor including: TR:O86541 (EMBL:AL031350) SC1F3.04 (261 aa), fasta scores opt: 1155 z-score: 1354.8 E():0 67.9% identity in 262 aa overlap and TR:O86718 (EMBL:AL031515) SC5C7.21C (271 aa), fasta scores opt: 894 z-score: 1050.3 E(): 0 54.0% identity in 272 aa overlap.
  
     0.767
SCO6536
SC5C7.21c, unknown, len: 271 aa; similar to two S. coelicolor hypothetical proteins SC1F2.04 (E(): 0, 51.3% identity in 269 aa overlap) and SC1F2.03c (E(): 4.5e-21, 44.7% identity in 275 aa overlap).
  
     0.766
SCO7617
SC2H2.15, hypothetical protein, len: 271 aa; similar to many Streptomyces coelicolor hypothetical proteins, e.g. TR:O86718 (EMBL:AL031515) hypothetical 29.3 kDa protein SC5C7.21c, 271 aa; fasta scores: opt: 863 z-score: 1030.6 E(): 0; 51.5% identity in 274 aa overlap.
  
     0.766
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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