STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO4482SCD69.02c, probable lysR-family transcriptional regulator, len: 286 aa; similar to TR:CAB55655 (EMBL:AL117385) Streptomyces coelicolor putative lysR-family transcriptional regulator SC5G9.07c, 287 aa; fasta scores: opt: 495 z-score: 551.1 E(): 3.1e-23; 37.0% identity in 297 aa overlap and to SW:ALSR_BACSU (EMBL:L04470) Bacillus subtilis als operon regulatory protein AlsR, 302 aa; fasta scores: opt: 390 z-score: 435.8 E(): 8.2e-17; 32.1% identity in 293 aa overlap. Contains Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family and match to Prosite [...] (286 aa)    
Predicted Functional Partners:
SCO4484
SCD69.04, possible integral membrane protein, len: 120 aa; similar to TR:O85187 (EMBL:AF051158) Vibrio cholerae sodium-proton antiporter affecting protein NhaA, 382 aa; fasta scores: opt: 116 z-score: 146.3 E(): 1.1; 32.2% identity in 118 aa overlap. Contains possible hydrophobic membrane spanning regions.
       0.784
SCO7640
SC10F4.13c, possible lysR-family transcriptional regulator, len: 327 aa; similar to many other Streptomyces coelicolor lysR-family transcriptional regulators, e.g. TR:Q9K3X6 (EMBL:AL359949) putative lysR-family transcriptional regulator 2SCG61.40c, 303 aa; fasta scores: opt: 376 z-score: 418.1 E(): 9.5e-16; 34.0% identity in 318 aa overlap. Contains Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family and possible helix-turn-helix motif at residues 16..37 (+5.92 SD).
  
     0.764
SCO7025
SC1H10.14c, probable LysR-family transcriptional regulator, len: 305 aa. Highly similar to the Streptomyces lividans TR:Q9ZI19 (EMBL:AF043654) putative LysR-type of transcriptional regulator, BxlS (300 aa), fasta scores opt: 1743 z-score: 1937.0 E(): 0 91.0% identity in 300 aa overlap. Also similar to many other putative LysR-family transcriptional regulators e.g. Streptomyces coelicolor TR:O86805 (EMBL:AL031317) putative transcriptional regulator, SC6G4.44 (306 aa), fasta scores opt: 479 z-score: 538.0 E(): 1.5e-22 38.3% identity in 300 aa overlap. Contains a Prosite hit to PS00044 Ba [...]
  
     0.760
SCO4766
SC6G4.44, probable transcriptional regulator, len: 306 aa; similar to many members of the lysR family e.g. CYNR_ ECOLI cyn operon transcriptional activator (299 aa), fasta scores; opt: 371 z-score: 524.3 E(): 5.8e-22, 30.3% identity in 307 aa overlap. Contains PS00044 Bacterial regulatory proteins, lysR family signature, helix-turn-helix motif at aa 18-39 (Score 1603, +4.65 SD) and Pfam match to entry PF0 0126 HTH_1, Bacterial regulatory helix-loop-helix proteins, lysR family, score 161.30, E-value 1.6e-44.
  
     0.750
SCO2757
SCC57A.28, possible LysR-family transcriptional regulator, len: 313 aa. Similar to several other regulators including: Escherichia coli SW:XAPR_ECOLI (EMBL:X63976) xanthosine operon regulatory protein (294 aa), fasta scores opt: 322 z-score: 366.5 E(): 5e-13 27.4% identity in 292 aa overlap. Also similar to several other putative Streptomyces coelicolor regulators including: TR:O86805 (EMBL:AL031317) SC6G4.44 (306 aa), fasta scores opt: 523 z-score: 590.0 E(): 1.8e-25 37.2% identity in 320 aa overlap and TR:CAB62680 (EMBL:AL133422) SCM1.22C (301 aa), fasta scores opt: 636 z-score: 715. [...]
  
     0.718
SCO6801
SC1A2.10, possible LysR-family transcriptional regulator, len: 300 aa. Similar to many other regulators e.g. Streptomyces coelicolor TR:CAB62680 (EMBL:AL133422) putative LysR-family transcriptional regulatory protein, SCM1.22C (301 aa), fasta scores opt: 673 z-score: 751.5 E():0 40.3% identity in 300 aa overlap. Contains 2x Prosite hits to PS00044 Bacterial regulatory proteins, lysR family signature and a Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family with the putative helix-turn-helix motif situated between residues 17..38 (+4.44 SD).
  
     0.718
SCO7438
SC6D11.34, possible LysR-family transcriptional regulatory protein, len: 311 aa. Similar to many LysR-family regulators involved in the control of nodulation e.g. Rhizobium sp. (strain NGR234) SW:NOD1_RHISN(EMBL:AE000065) nodulation protein D I (322 aa), fasta scores opt: 449 z-score: 537.5 E(): 1.6e-22 32.3% identity in 294 aa overlap. Contains a Prosite hit to PS00044 Bacterial regulatory proteins, lysR family signature and Pfam matches to PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family and Pfam match to entry PF01046 NodD_C_term, NodD transcription activato [...]
  
     0.710
SCO1616
SCI35.38c, probable transcriptional regulator, len: 325 aa; similar to many members of the lysR family CBBR_RHORU RUBISCO operon transcriptional regulator (298 aa), fasta scores; opt: 394 z-score: 410.2 E(): 1.3e-15, 30.2% identity in 295 aa overlap. Contains PS00044 Bacterial regulatory proteins, lysR family signature, possible helix-turn-helix motif at aa 53-74 (Score 1391, +3.92 SD), and Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix proteins, lysR family, score 129.30, E-value 7e-35.
  
     0.697
SCO4483
SCD69.03, hypothetical protein, len: 200 aa; similar to TR:Q9Z582 (EMBL:AL035569) Streptomyces coelicolor SC8D9.09 protein, 164 aa; fasta scores: opt: 246 z-score: 291.3 E(): 9.1e-09; 34.1% identity in 132 aa overlap.
 
    0.632
SCO3919
SCQ11.02c, abaB, probable lysR-family transcriptional regulator, len: 301 aa; previously sequenced as TR:Q53869 (EMBL:U37580) S.coelicolor lysR-like protein (301 aa). Highly similar to SW:ARAB_STRAT (EMBL:X91393), AraB, Streptomyces antibioticus transcriptional regulatory protein (301 aa), fasta scores; opt: 1581 z-score: 1813.2 E(): 0, 80.3% identity in 300 aa overlap. Similar to many other transcriptional regulators. Contains probable helix-turn-helix motif at aa 17-38 (Score 1659, +4.84 SD). Contains Pfam match to PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR fa [...]
  
     0.596
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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