STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO4493SCD69.13, probable asnC-family transcriptional regulator, len: 167 aa; similar to SW:LRPC_BACSU (EMBL:AB001488) Bacillus subtilis transcriptional regulator LrpC, 144 aa; fasta scores: opt: 249 z-score: 304.8 E(): 1.6e-09; 36.0% identity in 125 aa overlap. Contains Pfam match to entry PF01037 ASNC_trans_reg, AsnC family and match to Prosite entry PS00519 Bacterial regulatory proteins, asnC family signature. Contains a possible helix-turn-helix motif at residues 33..45 (+2.79 SD) and also a TTA leucine codon, possible target for bldA regulation. (167 aa)    
Predicted Functional Partners:
SCO4492
Putative octaprenyl carboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family.
       0.849
SCO4494
Conserved hypothetical protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.
  
    0.820
SCO5404
SC8F4.08, probable two-component sensor kinase, len: 478 aa; similar to many proposed two-component sensor kinases eg. SW:P18392 (RSTB_ECOLI) sensor protein RstB from Escherichia coli (433 aa) fasta scores; opt: 379, z-score: 410.8, E(): 1.8e-15, 35.6% identity in 239 aa overlap. Contains Pfam match to entry PF00672 DUF5, Domain found in bacterial signal proteins and Pfam match to entry PF00512 signal, Histidine kinase.
      
 0.770
SCO5592
SC2E1.09, unknown, len: 79 aa; highly similar to small hypothetical proteins from several organisms, e.g. YX40_MYCTU MTCY274.40c (80 aa), fasta scores; opt: 356 z-score:628.4 E(): 9.1e-28, 71.6% identity in 74 aa overlap; Belongs to the UPF0109 family.
      
 0.770
SCO5783
SC4H2.04c, hypothetical protein, len: 161 aa; similar to hypothetical proteins from several organisms e.g. M. tuberculosis TR:O05882 (EMBL:Z95121) MTCY20B11.12C (160 aa), fasta scores; opt: 315 z-score: 557.4 E(): 8e-24, 40.0% identity in 150 aa overlap (also upstream of a putative transport protein).
      
 0.770
SCO6482
SC9C7.18, conserved hypothetical protein, len: 348 aa; similar to two hypothetical proteins e.g. TR:O69685 (EMBL:AL022121) Mycobacterium tuberculosis RV03718c or MTV025.066c, 147 aa; fasta scores; opt: 475, z-score: 768.3, E(): 0, (52.1% identity in 146 aa overlap).
      
 0.770
SCO1210
2SCG58.10, probable transcriptional regulatory protein, len: 218 aa; similar to TR:O53757 (EMBL:AL021933) Mycobacterium tuberculosis putative regulatory protein MTV038.16c, 234 aa; fasta scores: opt: 214 z-score: 258.1 E(): 6.5e-07; 30.7% identity in 199 aa overlap. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family and possible helix-turn-helix motif at residues 35..56 (+3.27 SD).
      
 0.743
SCO4495
SCD35.02, possible DNA polymerase related protein, len: 212 aa; similar to TR:AAF11304 (EMBL:AE002016) Deinococcus radiodurans DNA polymerase-related protein DR1751, 237 aa; fasta scores: opt: 380 z-score: 451.4 E(): 1e-1; 41.5% identity in 188 aa overlap and to N-terminal region of SW:DPOL_BPSP1 (EMBL:M84415) Bacteriophage SP01 DNA polymerase (EC 2.7.7.7) 31, 924 aa; fasta scores: opt: 191 z-score: 223.4 E(): 5.2e-05; 33.7% identity in 169 aa overlap.
       0.708
SCO3832
SCH69.02, possible transcriptional regulator, len: 135 aa; similar to many e.g. SW:LRP_ECOLI leucine-responsive regulatory protein from Escherichia coli (163 aa) fasta scores; opt: 181, z-score: 249.4, E(): 1.5e-06, (29.5% identity in 129 aa overlap). Contains Pfam match to entry PF01037 ASNC_trans_reg, AsnC family and a probable helix-turn-helix 9-30 aa (+3.69 SD).
  
     0.700
SCO2140
SC6G10.13, possible transcriptional regulator, len: 93 aa; similar to many e.g. TR:O28868 (EMBL:AE001007) transcriptional regulatory protein, AsnC family from Archaeoglobus fulgidus (77 aa) fasta scores; opt: 148, z-score: 216.7, E(): 9.1e-05, (40.8% identity in 71 aa overlap) and SW: LRP_ECOLI Lrp, leucine responsive regulatory protein from Escherichia coli (163 aa) fasta scores; opt: 107, z-score: 157.6, E(): 0.18, (24.7% identity in 85 aa overlap).
      
 0.669
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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