STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO4518SCD35.25c, possible integral membrane protein, len: 449 aa. Contains possible hydrophobic membrane spanning regions and possible colied-coil region at aprox. residues 82..110. (449 aa)    
Predicted Functional Partners:
SCO4517
SCD35.24c, hypothetical protein, len: 241 aa; C-terminal region similar to TR:Q9KYA0 (EMBL:AL356813) Streptomyces coelicolor conserved hypothetical protein SCK15.04c, 216 aa; fasta scores: opt: 613 Z-score: 714.3 E(): 3.8e-32; 52.792% identity in 197 aa overlap.
       0.797
SCO4519
SCD35.26, possible integral membrane protein, len: 198 aa; similar to TR:Q9KYA1 (EMBL:AL356813) putative integral membrane protein SCK15.03 from Streptomyces coelicolor (213 aa) fasta scores; opt: 349, Z-score: 400.7, E(): 1.1e-14, 37.363% identity (37.989% ungapped) in 182 aa overlap. Contains possible hydrophobic membrane spanning regions.
       0.557
SCO7200
Hypothetical protein SC1D2.03c; SC1D2.03c, unknown, len: 181 aa. Weakly similar to several proteins of unknown function e.g. Streptomyces coelicolor TR:CAB88434 (EMBL:AL353815) hypothetical 15.8 kd protein, SCD6.05C (139 aa), fasta scores opt: 147 z-score: 192.6 E(): 0.003 34.2% identity in 120 aa overlap.
  
     0.554
SCO4515
Putative membrane protein; SCD35.22c, hypothetical protein, len: 401 aa; similar to TR:Q9XD98 (EMBL:AF106004) Streptomyces coelicolor hypothetical 27.5 kD protein, 249 aa; fasta scores: opt: 190 z-score: 190.8 E(): 0.0034; 26.8% identity in 190 aa overlap and to TR:Q9F3G6 (EMBL:AL392175) Streptomyces coelicolor putative membrane protein 2SCD4.05, 474 aa; fasta scores: opt: 583 Z-score: 556.4 E(): 2.3e-23; 36.422% identity in 313 aa overlap. Contains possible hydrophobic membrane spanning regions and also possible colied-coil region ar aprox. residues 104..127.
 
    
0.511
SCO6514
Hypothetical protein SC1E6.23; SC1E6.23, unknown, len: 92 aa.
  
     0.492
SCO4511
SCD35.18c, possible integral membrane protein, len: 139 aa. Contains possible hydrophobic membrane spanning region.
       0.477
SCO7820
Hypothetical protein SC8E7.17; SC8E7.17, doubtful CDS, len: 148 aa.
  
     0.467
SCO6593
Hypothetical protein; SC8A6.14c, unknown, len: 1147 aa; contains two Ala-rich domains, PS00017 ATP/GTP-binding site motif A (P-loop) and probable coiled-coil regions from 238 to 292, 399 to 441, 445 to 488, 490 to 573, 786 to 820, and 829 to 871.
  
     0.451
SCP1.201
Hypothetical protein; SCP1.201, unknown, len: 1336aa; similar to TR:O87848 (EMBL:AL031013) hypothetical protein from Streptomyces coelicolor (1147 aa) fasta scores; opt: 1652, z-score: 1478.4, E(): 0, 38.7% identity in 926 aa overlap. Note possible alternative upstream translational start site which would give a possible N-terminal signal sequence. Contains several possible coiled-coil regions.
  
     0.450
SCO5735
SC3C3.21, probable integral membrane protein, len: 491 aa; similar to hypothetical membrane protein from M. tuberculosis TR:O06265 (EMBL:Z95389) MTCY77.20 Rv3448 (467 aa), fasta scores; opt: 192 z-score: 322.0 E(): 1.1e-10, 26.9% identity in 495 aa overlap.
   
    0.447
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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