STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO4555SCD16A.28c, possible integral membrane transferase, len: 363aa; similar to TR:Q56803 (EMBL:X78451) O-acetyl transferase from Xanthomonas campestris (364 aa) fasta scores; opt: 123, z-score: 149.6, E(): 0.53, (26.2% identity in 378 aa overlap). Contains possible membrane spanning hydrophobic regions. (363 aa)    
Predicted Functional Partners:
SCO4554
SCD16A.29c, possible bi-functional transferase/deacetylase, len: 743aa; 380-620aa region similar to TR:BAA35803 (EMBL:D90739) glycosyl transferase from Escherichia coli (441 aa) fasta scores; opt: 518, z-score: 576.7, E(): 8.6e-25, (35.4% identity in 257 aa overlap). 100-290aa region similar to SW:NODB_RHIME chitooligosaccharide deactylase from Rhizobium meliloti (217 aa) fasta scores; opt: 398, z-score: 448.0, E(): 1.3e-17, (35.7% identity in 196 aa overlap). Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases. Also contains possible membrane spanning hydrophob [...]
  
 0.973
SCO2962
SCE59.21c, possible bi-functional transferase/deacetylase, len: 734 aa; similar to TR:Q9XAP6 (EMBL:AL078618) Streptomyces coelicolor putative bi-functional transferase/deacetylase SC10A7.29c, 743 aa; fasta scores: opt: 2045 z-score: 2233.4 E(): 0; 59.5% identity in 726 aa overlap and N-terminal region similar to SW:NODB_RHIME (EMBL:X01649) Rhizobium meliloti chitooligosaccharide deacetylase (EC 3.5.1.-) (nodulation protein B) NodB, 217 aa; fasta scores: opt: 411 z-score: 455.6 E(): 5.8e-18; 37.9% identity in 198 aa overlap. Contains Pfam match to entry PF01522 Polysac_deacet, Polysacch [...]
  
 0.887
SCO4553
SCD16A.30c, putative membrane protein, len: 139 aa. Contains possible hydrophobic membrane spanning regions.
       0.855
SCO2961
SCE59.20c, possible integral membrane protein, len: 401 aa; similar to TR:Q9XAP7 (EMBL:AL078618) Streptomyces coelicolor putative integral membrane transferase SC10A7.28c, 363 aa; fasta scores: opt: 397 z-score: 390.6 E(): 2.4e-14; 46.6% identity in 369 aa overlap. Contains possible hydrophobic membrane spanning regions and match to Prosite entry PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature.
  
  
0.854
SCO4556
Putative ubiquinone/menaquinone methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
  
  
 0.828
SCO1388
SC1A8A.08c, possible mannose-1-phosphate guanyltransferase, len: 831aa; similar to many eg. TR:P74589 (EMBL:D90916) putative mannose-1-phosphate guanyltransferase from Synechocystis sp. (strain PCC 6803) (843 aa) fasta scores; opt: 2184, z-score: 2364.6, E(): 0, 39.7% identity in 817 aa overlap and SW:P41940 (MPG1_YEAST) mannose-1-phosphate guanyltransferase from Saccharomyces cerevisiae (Baker's yeast) (361 aa). Contains Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase, four Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats) and P [...]
  
 
 0.769
SCO2817
SCBAC17F8.08c, conserved hypothetical protein, len: 634 aa: similar in regions to many proteins of varying lengths e.g. TR:Q9RCY2 (EMBL:AL133469) hypothetical protein SCM10.16c from Streptomyces coelicolor (714 aa) fasta scores; opt: 1259, Z-score: 1358.4, 43.960% identity (46.454% ungapped) in 596 aa overlap and TR:Q9HVI8 (EMBL:AE004874) hypothetical protein from Pseudomonas aeruginosa (1415 aa) fasta scores; opt: 961, Z-score: 1032.5, 36.825% identity (40.250% ungapped) in 611 aa overlap. Contains Pfam match to entry PF00563 EAL, Domain of unknown function and Pfam match to entry PF0 [...]
  
  
 0.755
SCO2712
SCC61A.33, possible membrane protein, len: 239aa; weakly similar to TR:Q9X4U6 (EMBL:AF118389) from cps locus of Streptococcus suis serotype 2 (229 aa) fasta scores; opt: 161, z-score: 172.0, E(): 0.04, 28.4% identity in 176 aa overlap. Contains possible membrane-spanning hydrophobic regions.
  
  
 0.751
SCO6827
SC4A9.04c, polyketide synthase, len: 2358 aa. Highly similar to many including: Stigmatella aurantiaca TR:AAF19813(EMBL:AF188287) polyketide synthase, MtAE, found within the Myxothiazol biosynthetic gene cluster (1947 aa), fasta scores opt: 2671 z-score: 2436.5 E():0 35.8% identity in 1770 aa overlap and Mycobacterium tuberculosis SW:PPSA_MYCTU(EMBL:Z74697) phenolpthiocerol synthesis polyketide synthase gene, PpsA (1876 aa), fasta scores opt: 2221 z-score: 2025.5 E(): 0 33.6% identity in 1761 aa overlap. Contains Prosite hits to PS00606 Beta-ketoacyl synthases active site and 2xPS00012 [...]
  
 
 0.726
SCO2003
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.693
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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