STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO4576Hypothetical protein; SCD16A.07, unknown, len: 199 aa; weakly similar to others eg. TR:Q55360 (EMBL:D64003) hypothetical protein from Synechocystis sp. strain PCC6803 (190 aa) fasta scores; opt: 168, z-score: 209.8, E(): 0.00023, (26.6% identity in 177 aa overlap). (199 aa)    
Predicted Functional Partners:
SCO4080
Conserved hypothetical protein SCD25.16c; SCD25.16c, unknown, len: 194 aa. Shares a low level of similarity with Streptomyces coelicolor TR:CAB44517 (EMBL; AL078618) hypothetical 22.4 KD protein SC10A7.07 (199 aa), fasta scores opt: 155 z-score: 201.1 E(): 0.00076 25.9% identity in 185 aa overlap. Also similar to TR:Q9L1Y1 (EMBL:AL138662) Streptomyces coelicolor hypothetical protein SC8E4A.24, 194 aa; fasta scores: opt: 705 Z-score: 859.5 E(): 3e-40; 57.576% identity in 198 aa overlap.
  
     0.550
SCO4354
SCD19.09c, hypothetical protein, len: 227 aa; similar to TR:Q9RDD3 (EMBL:AL136503) Streptomyces coelicolor hypothetical 25.0 kDa protein SCC77.25c, 224 aa; fasta scores: opt: 234 z-score: 297.1 E(): 4.8e-09; 30.3% identity in 208 aa overlap.
  
     0.550
SCO2558
Hypothetical protein SCC77.25c; SCC77.25c, unknown, len: 224 aa.
  
     0.490
SCO4577
SCD16A.06c, probable helicase, len: 676aa; similar to many (both prokaryote and eukaryote) egs. TR:AAD05424 (EMBL:AF047374) RecQ helicase from Neisseria gonorrhoeae (767 aa) fasta scores; opt: 1809, z-score: 1769.1, E(): 0, (50.4% identity in 601 aa overlap) and SW:HUS2_SCHPO ATP-dependent helicase from Schizosaccharomyces pombe (1328 aa) fasta scores; opt: 1013, z-score: 988.7, E(): 0, (40.2% identity in 493 aa overlap). Contains Pfam match to entry PF00271 helicase_C, Helicases conserved C-terminal domain, score 78.40, E-value 1.4e-19.
       0.480
SCO5077
SCBAC28G1.03, actVA2, hypothetical protein, len: 131 aa; identical to previously sequenced TR:Q53904 (EMBL:X58833) Streptomyces coelicolor 6 ActVA region genes of the actinorhodin biosynthetic gene cluster, ActVA2, 131 aa.
  
     0.446
SCO4449
Putative hydrolase; Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2- amino-butenoic acid; Belongs to the Vgb family.
  
     0.432
SCO3236
Putative oxygenase; Catalyzes the 3-hydroxylation of L-asparagine to (2S,3S)-3- hydroxyasparagine. The 3-hydroxylated asparagine produced is incorporated at position 9 during the biosynthesis of the non- ribosomally synthesized calcium-dependent antibiotic (CDA), a 11- residue acidic lipopeptide lactone. Is able to hydroxylate only free L- asparagine, since it hydroxylates neither a CDA analog with unmodified Asn at position 9 nor a peptidyl-carrier-protein (PCP)-bound asparagine. Is not active toward D-asparagine. Belongs to the clavaminate synthase family.
  
     0.417
SCO5327
SC6G9.06c, possible transposase, len: 247 aa; similar to TR:Q48342 (EMBL:M28508) Streptomyces lividans ORFA from insertion element IS493 (254 aa), fasta scores; opt: 585 z-score: 725.3 E(): 4.5e-33, 45.0% identity in 220 aa overlap. Contains probable helix-turn-helix motif at aa 49-70 (Score 1540, +4.43 SD).
  
     0.409
SCP1.186
SCP1.186, conserved hypothetical protein, len: 282aa; similar to other hypothetical proteins from streptomycetes eg. SCE6.06 (TR:Q9KZT2 EMBL:AL353832) from Streptomyces coelicolor (281 aa) fasta scores; opt: 882, z-score: 1083.5, E(): 0, 47.9% identity in 280 aa overlap. Note possible alternative downstream translational start site.
  
     0.403
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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