STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO4771SCD63.03, possible inosine-5'-monophosphate dehydrogenase, len: 374 aa; N-terminal region identical to previously sequenced TR:O86845 (EMBL:AJ010601) Streptomyces coelicolor hypothetical 38.9 kD protein (fragment), 84 aa and whole CDS similar to SW:IMDH_ECOLI (EMBL:X02209) Escherichia coli inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) GuaB, 488 aa; fasta scores: opt: 275 z-score: 311.9 E(): 6.1e-10; 29.0% identity in 376 aa overlap. Contains Pfam matches to entries PF01574 IMPDH_N, IMP dehydrogenase / GMP reductase N terminus PF00478 IMPDH_C, IMP dehydrogenase / GMP reductase C [...] (374 aa)    
Predicted Functional Partners:
SCO4785
GMP synthase; Catalyzes the synthesis of GMP from XMP.
 
 0.998
SCO3629
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 
 0.988
SCO4770
Inosine 5' monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
0.987
SCO4814
SCD63A.25, purH, bifunctional purine biosynthesis protein, len: 523 aa; highly similar to TR:AAF05727 (EMBL:AF191543) Mycobacterium paratuberculosis phosphoribosylaminoimidazolecarboxamide/formyltransferase, PurH, 527 aa; fasta scores: opt: 2301 z-score: 2632.5 E(): 0; 69.1% identity in 518 aa overlap. Contains Pfam match to entry PF01808 AICARFT_IMPCHas, AICARFT/IMPCHase bienzyme.
 
 
 0.978
SCO3405
SCE9.12c, hprT, probable hypoxanthine phosphoribosyltransferase, len: 187 aa; similar to many e.g. TR:O33799 (EMBL:AF008931), HprT, Salmonella typhimurium hypoxanthine phosphoribosyltransferase (178 aa), fasta scores; opt: 583 z-score: 711.2 E(): 2.7e-32, 54.2% identity in 166 aa overlap. The start codon is uncertain as there are 5 potential. Contains Pfam match to entry PF00156 Pribosyltran, Purine/pyrimidine phosphoribosyl transferases, score 177.70, E-value 1.9e-49 and PS00103 Purine/pyrimidine phosphoribosyl transferases signature. Contains probable coiled-coil from 3 to 39 (37 res [...]
    
 0.955
SCO2902
Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
 0.920
SCO1461
SCL6.18c, guaB2, probable inosine monophosphate dehydrogenase, len: 483 aa; similar to SW:IMDH_BACSU (EMBL:X55669) Bacillus subtilis inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) GuaB, 513 aa; fasta scores: opt: 970 z-score: 1018.4 E(): 0; 37.4% identity in 471 aa overlap. Contains Pfam match to entry PF01574 IMPDH_N, IMP dehydrogenase / GMP reductase N terminus, two matches to entry PF00571 CBS, CBS domain and to entry PF00478 IMPDH_C, IMP dehydrogenase / GMP reductase C terminus.
     
0.913
SCO4152
SCD84.19, possible secreted 5'-nucleotidase, len: 612 aa; similar to SW:5NTD_DISOM (EMBL:X62278) Discopyge ommata 5'-nucleotidase precursor (EC 3.1.3.5) (ecto-nucleotidase), 577 aa; fasta scores: opt: 322 z-score: 332.6 E(): 4.6e-11; 24.6% identity in 574 aa overlap. Contains Pfam match to entry PF01009 5_nucleotidase, 5'-nucleotidase and possible N-terminal region signal peptide sequence; Belongs to the 5'-nucleotidase family.
    
 0.907
SCO3100
SCE41.09c, conserved hypothetical protein, len: 325 aa; similar to SW:YBL1_STRCI (EMBL:D00937) Streptomyces cacaoi hypothetical 26.1 kDa protein in BlaB 3' region, 242 aa; fasta scores: opt: 1157 z-score: 1300.4 E(): 0; 72.7% identity in 242 aa overlap.
     
  0.900
SCO1594
SCI35.16c, pheT, proabable phenylalanyl-tRNA synthetase beta chain, len: 840 aa; similar to many e.g. SYFB_ECOLI phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) (795 aa), fasta scores; opt: 988 z-score: 1290.9 E(): 0, 36.0% identity in 849 aa overlap. Contains PS00017 ATP/GTP-binding.
   
  
 0.830
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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