STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO49512SCK31.11c, probable aldoketoreductase, len: 345 aa; similar to TR:Q9XC70 (EMBL:AF147704) Streptomyces fradiae NDP-hexose 2,3-enoyl reductase TylCII, 329 aa; fasta scores: opt: 726 z-score: 830.3 E(): 0; 41.3% identity in 320 aa overlap. Contains 2x Pfam matches to entry PF00248 aldo_ket_red, Aldo/keto reductase family. (345 aa)    
Predicted Functional Partners:
SCO5098
SCBAC28G1.24, possible integral membrane protein, len: 154 aa; identical in its C-terminal domain to TR:Q9X9U7 (EMBL:Y18817) Streptomyces coelicolor A3(2) hypothetical 11.9 kDa protein ORF11, 113 aa. Contains possible hydrophobic membrane spanning regions and 10x degenerate repeat at N-terminal region: M(P/V). Alternative start codon in previously sequence EMBL entrance after the repeat region at residue 42.
      
 0.850
SCO4952
2SCK31.12, probable tetR-family transcriptional regulator, len: 198 aa; similar to TR:Q9RJL5 (EMBL:AL121849) Streptomyces coelicolor putative tetR-family transcriptional regulator SCF6.16, 194 aa; fasta scores: opt: 355 z-score: 451.5 E(): 1.3e-17; 35.1% identity in 185 aa overlap. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family and possible helix-turn-helix motif at residues 42..63 (+4.18 SD).
 
     0.631
SCO5088
SCBAC28G1.14, actIORF2, actinorhodin polyketide beta-ketoacyl synthase beta subunit (also known as chain length factor), len: 407 aa; identical to previously sequenced SW:KASB_STRCO (EMBL:X63449) Streptomyces coelicolor actinorhodin polyketide putative beta-ketoacyl synthase 2 ActI ORF2, 407 aa. Contains Pfam matches to entries PF00109 ketoacyl-synt, Beta-ketoacyl synthase, N-terminal domain and PF02801 ketoacyl-synt_C, Beta-ketoacyl synthase, C-terminal domain.
      
 0.510
SCO5095
SCBAC28G1.21, ORF9, probable DNA-binding protein, len: 190 aa; identical to previously sequenced as TR:Q9X9V0 (EMBL:Y18817) Streptomyces coelicolor A3(2) hypothetical 20.6 kDa protein ORF9, 190 aa and similar to TR:O86784 (EMBL:AL031317) Streptomyces coelicolor SC6G4.21, 202 aa; fasta scores: opt: 642 Z-score: 656.2 bits: 128.2 E(): 7.9e-31; 53.968% identity in 189 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and possible helix-turn-helix motif at residues 25..46 (+6.01 SD).
      
 0.483
SCO4953
Hypothetical protein 2SCK31.13; 2SCK31.13, unknown, len: 64 aa.
       0.432
SCO0299
SC5G9.08, possible oxidoreductase, len: 294 aa; shows weak similarity to TR:P06632 (EMBL:M12799) Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase (278 aa), fasta scores; opt: 196 z-score: 229.3 E(): 2.1e-05, 27.6% identity in 286 aa overlap. Similar to many hypothetical oxidoreductases e.g. SW:YDBC_ECOLI (EMBL:X62680), YbcD, Escherichia coli hypothetical oxidoreductase (286 aa) (63.3% identity in 283 aa overlap). Also similar to SC5H1.28C (EMBL:AL049863) Streptomyces coelicolor putative oxidoreductase (305 aa) (46.5% identity in 301 aa overlap).
  
     0.412
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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