STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO5019SCK15.21c, possible secreted protein, len: 201 aa; similar to TR:Q9UZM5 (EMBL:AJ248286;) Pyrococcus abyssi hypothetical 13.4 kD protein, 117 aa; fasta scores: opt: 167 z-score: 206.8 E(): 0.00048; 31.0% identity in 100 aa overlap. Contains possible N-terminal region signal peptide sequence. (201 aa)    
Predicted Functional Partners:
SCO5010
SCK15.12, possible integral membrane protein, len: 316 aa; similar to TR:AAF40196 (EMBL:AF229646) Caulobacter crescentus hypothetical 34.6 kD protein, 325 aa; fasta scores: opt: 287 z-score: 328.2 E(): 8.2e-11; 21.9% identity in 315 aa overlap. Contains possible N-terminal region signal peptide sequence and possible hydrophobic membrane spanning regions.
 
     0.737
SCO5011
SCK15.13, possible integral membrane protein, len: 300 aa; similar to TR:O27061 (EMBL:AE000871) Methanobacterium thermoautotrophicum conserved protein MTH980, 313 aa; fasta scores: opt: 235 z-score: 285.2 E(): 2e-08; 27.7% identity in 238 aa overlap. Contains possible N-terminal region signal peptide sequence and possible hydrophobic membrane spanning regions.
 
     0.717
SCO5009
SCK15.11, probable secretory protein, len: 445 aa; similar to TR:P94647 (EMBL:U77780) Chlorobium limicola secretory protein kinase Kbh, 474 aa; fasta scores: opt: 1192 z-score: 1311.8 E(): 0; 47.7% identity in 396 aa overlap, to SW:TRBB_AGRT6 (EMBL:U43675) Agrobacterium tumefaciens conjugal transfer protein TrbB, 323 aa; fasta scores: opt: 512 z-score: 568.9 E(): 3.2e-24; 30.4% identity in 326 aa overlap and to TR:Q9X921 (EMBL:AL035636) Streptomyces coelicolor putative secretory protein SCH5.19c, 523 aa; fasta scores: opt: 878 z-score: 847.4 E(): 0; 40.3% identity in 365 aa overlap. Co [...]
 
     0.636
SCO5024
SCK15.26, possible oxidoreductase, len: 290 aa; similar to TR:Q9UXP0 (EMBL:AJ011519) Methanolobus tindarius F420-dependent N5,N10-methylene-tetrahydromethanopterin reductase, putative FfdA, 326 aa; fasta scores: opt: 323 z-score: 369.8 E(): 4e-13; 28.3% identity in 240 aa overlap.
       0.629
SCO5026
SCK15.28, hypothetical protein, len: 272 aa; similar to TR:O06593 (EMBL:Z95586) Mycobacterium tuberculosis hypothetical 27.9 kD protein MTCY336.07c, 252 aa; fasta scores: opt: 968 z-score: 1156.3 E(): 0; 57.5% identity in 254 aa overlap.
       0.618
SCO5006
SCK15.08, minD1, possible septum site-determining protein, len: 418 aa; N-terminal domain similar to TR:Q9RZD9 (EMBL:AE001862) Deinococcus radiodurans DNA-binding response regulator DRA0010, 211 aa; blastp scores: Score = 103 (36.3 bits), Expect = 0.0045, Identities = 50/194 (25%), Positives = 85/194 (43%) and C-terminal domain highly similar to TR:Q9ZF15 (EMBL:AJ005576) Streptomyces griseus septum site-determining protein MinD protein, 396 aa; fasta scores: opt: 1230 z-score: 1302.8 E(): 0; 70.5% identity in 281 aa overlap. Contains Pfam matches to entries PF00072 response_reg, Respon [...]
 
     0.616
SCO5020
SCK15.22, hypothetical protein, len: 178 aa; similar to C-terminal region of TR:Q9KY81 (EMBL:AL356813) Streptomyces coelicolor putative lipoprotein SCK15.23, 221 aa; fasta scores: opt: 444 Z-score: 519.8 E(): 2.5e-21; 39.080% identity in 174 aa overlap.
       0.606
SCO4549
SCD16A.34c, possible type IV peptidase, len: 259aa; similar to many eg. SW:LEP3_PSEAE type IV prepilin peptidase from Pseudomonas aeruginosa (290 aa) fasta scores; opt: 304, z-score: 344.8, E(): 7e-12, (32.5% identity in 228 aa overlap). Contains possible hydrophobic membrane spanning regions; Belongs to the peptidase A24 family.
       0.560
SCP1.169
SCP1.169, possible ATP/GTP-binding protein, len: 537aa; contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop).
 
     0.554
SCO3556
SCH5.19c, possible secretory protein, len: 523 aa; similar to many of undefined function eg. TR:O69627 (EMBL:AL022121) hypothetical protein from Mycobacterium tuberculosis (352 aa) fasta scores; opt: 1287, z-score: 1191.3, E(): 0, (59.8% identity in 351 aa overlap) and SW:TRBB_AGRT6 conjugal transfer protein from Agrobacterium tumefaciens (323 aa) fasta scores; opt: 469, z-score: 441.4, E(): 2.8e-17, (31.4% identity in 287 aa overlap). Contains Pfam match to entry PF00437 GSPII_E, Bacterial type II secretion system protein, score 41.30, E-value 1.6e-11. Also contains PS00017 ATP/GTP-bi [...]
 
     0.535
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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