STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO5093SCBAC28G1.19c, ORF7, putative mini-circle protein, len: 165 aa; identical to previously sequenced TR:Q9X9V2 (EMBL:Y18817) Streptomyces coelicolor A3(2) putative mini-circle protein ORF7, 165 aa. (165 aa)    
Predicted Functional Partners:
SCO5094
SCBAC28G1.20c, ORF8, putative methyltransferase, len: 208 aa; identical to previously sequenced TR:Q9X9V1 (EMBL:Y18817) Streptomyces coelicolor A3(2) putative methyltransferase ORF8, 208 aa.
 
   
 0.983
SCO5095
SCBAC28G1.21, ORF9, probable DNA-binding protein, len: 190 aa; identical to previously sequenced as TR:Q9X9V0 (EMBL:Y18817) Streptomyces coelicolor A3(2) hypothetical 20.6 kDa protein ORF9, 190 aa and similar to TR:O86784 (EMBL:AL031317) Streptomyces coelicolor SC6G4.21, 202 aa; fasta scores: opt: 642 Z-score: 656.2 bits: 128.2 E(): 7.9e-31; 53.968% identity in 189 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and possible helix-turn-helix motif at residues 25..46 (+6.01 SD).
     
 0.939
SCO5098
SCBAC28G1.24, possible integral membrane protein, len: 154 aa; identical in its C-terminal domain to TR:Q9X9U7 (EMBL:Y18817) Streptomyces coelicolor A3(2) hypothetical 11.9 kDa protein ORF11, 113 aa. Contains possible hydrophobic membrane spanning regions and 10x degenerate repeat at N-terminal region: M(P/V). Alternative start codon in previously sequence EMBL entrance after the repeat region at residue 42.
  
   
 0.758
SCO5075
SCBAC28G1.01, possible oxidoreductase, previously sequenced as ORF4, len: 167 aa; identical to C-terminal region of previously sequenced TR:Q53929 (EMBL:X62373) Streptomyces coelicolor ORF4, 306 aa; fasta scores: opt: 1029 Z-score: 1146.7 bits: 219.4 E(): 2.9e-56; 95.808% identity in 167 aa overlap. Contains match to Prosite entry PS01162 Quinone oxidoreductase / zeta-crystallin signature; SCBAC20F6.18, ORF4, possible oxidoreductase, len: 170 aa; identical to N-terminal region of the previously sequenced TR:Q53929 (EMBL:X62373) Streptomyces coelicolor ORF 4, 306 aa. Contains match to P [...]
      
 0.669
mmyC
Putative acyl carrier protein synthase, MmyC; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family.
      
 0.646
SCO3246
Putative 3-oxoacyl-[acyl carrier protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family.
      
 0.518
SCO1271
2SCG18.18c, fabH3, probable 3-oxoacyl-[acyl-carrier-protein] synthase III, len: 317 aa; similar to TR:FABH_ECOLI (EMBL:M77744) Escherichia coli 3-oxoacyl-[acyl-carrier-protein] synthase III (KASIII) FabH, 317 aa; fasta scores: opt: 526 z-score: 548.1 E(): 4.8e-23; 30.2% identity in 318 aa overlap and to TR:Q9ZBV4 (EMBL:AL034443) Streptomyces coelicolor FabH2, 3-oxoacyl-[acyl-carrier-protein] synthase IIe SC4B5.14, 316 aa; fasta scores: opt: 701 z-score: 636.7 E(): 7.2e-30; 38.7% identity in 323 aa overlap.
      
 0.513
SCO5092
SCBAC28G1.18, actVB, actinorhodin polyketide possible dimerase, len: 177 aa; identical to previously sequenced SW:DIM6_STRCO (EMBL:X63449) Streptomyces coelicolor actinorhodin polyketide dimerase ActI ORF6, ActVB, 177 aa Contains Pfam match to entry PF01613 Flavin_Reduct, Flavin reductase like domain.
      
 0.510
SCO1648
AAA ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
  
   
 0.508
SCO2603
SCC88.14, possible integrase, len: 518 aa; similar to TR:Q38184 (EMBL:X85213) Bacteriophage TP901-1 integrase, 485 aa; fasta scores: opt: 212 z-score: 243.5 E(): 3.8e-06; 24.2% identity in 417 aa overlap. Contains TTA leucine codon, possible target for bldA regulation.
   
  
 0.490
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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