STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO51782SC3B6.02, possible sulfurylase, len: 392 aa; similar to TR:AAF33130 (EMBL:AF196567) Pseudomonas stutzeri putative sulfurylase, 391 aa; fasta scores: opt: 1433 z-score: 1624.0 E(): 0; 56.2% identity in 395 aa overlap and to SW:MOEB_ECOLI (EMBL:M21151) Escherichia coli molybdopterin biosynthesis MoeB protein, 249 aa; blastp socres: Score = 526 (185.2 bits), Expect = 1.1e-50, P = 1.1e-5, Identities = 106/249 (42%), Positives = 156/249 (62%). Contains Pfam match to entry PF00899 ThiF_family, ThiF family and PF00581 Rhodanese, Rhodanese-like domain. (392 aa)    
Predicted Functional Partners:
SCO2157
SC6G10.30, probable aminotransferase, len: 460 aa; similar to many NifS-like proteins e.g. SW:NIFS_RHOSH NifS protein from Rhodobacter sphaeroides (387 aa) fasta scores; opt: 702, z-score: 760.5, E(): 0, (37.4% identity in 390 aa overlap). Contains Pfam matches to entry PF00266 aminotran_5, Aminotransferases class-V and entry PF01206 UPF0033, Uncharacterized protein family UPF0033; Belongs to the sulfur carrier protein TusA family.
  
 0.997
SCO2911
SCE19A.11c, conserved hypothetical protein, len: 92 aa; unknown function, similar to hypothetical proteins from other organisms e.g. SW:Y03K_MYCTU (EMBL:Z73902) Mycobacterium tuberculosis hypothetical protein (93 aa), fasta scores; opt: 341 z-score: 451.3 E(): 8.3e-18, 57.0% identity in 93 aa overlap.
 
 0.994
SCO4294
SCD95A.27, hypothetical protein, len: 91 aa; similar to SW:Y03K_MYCTU (EMBL:Z73902) Mycobacterium tuberculosis hypothetical 9.6 kD protein MTCY130.20, 93 aa; fasta scores: opt: 369 z-score: 480.3 E(): 2.7e-19; 63.4% identity in 93 aa overlap, to TR:CAB50992 (EMBL:AL096852) Streptomyces coelicolor hypothetical protein SCE19A.11c, 92 aa; fasta scores: opt: 332 z-score: 416.4 E(): 1.2e-17; 54.9% identity in 91 aa overlap and highly similar to TR:Q9EUR9 (EMBL:AJ250537) Streptomyces hygroscopicus hypothetical protein, 92 aa; fasta scores: opt: 496 Z-score: 626.4 E(): 2.9e-27; 83.516% identi [...]
 
 0.994
SCO4161
SCD84.28, possible molybdopterin converting factor, len: 84 aa; similar to TR:O53880 (EMBL:AL022004) Mycobacterium tuberculosis putative molybdopterin converting factor (subunit 1) MoaD-2, 92 aa; fasta scores: opt: 191 z-score: 269.0 E(): 1.6e-07; 45.9% identity in 85 aa overlap.
 
 0.992
SCO5486
SC2A11.20, probable pyridoxal-phosphate-dependent aminotransferase, len: 389 aa; similar to many e.g. NIFS_ANASP Anaebaena NifS protein (400 aa), fasta scores; opt: 855 z-score: 1070.8 E(): 0, 40.4% identity in 384 aa overlap and SPL1_CANAL Candida albicans tRNA splicing protein SPL1 (488 aa), fasta scores; opt: 791 z-score: 912.8 E(): 0, 36.6% identity in 388 aa overlap. Contains Pfam match to entry PF00266 aminotran_5, Aminotransferases class-V, score 259.00, E-value 6.2e-74.
 
 
 0.987
SCO5201
2SC3B6.25, moaE-like protein, len: 152 aa; similar to SW:MOAE_ECOLI (EMBL:X70420) Escherichia coli molybdopterin [mpt] converting factor, subunit 2 MoaE, 149 aa; fasta scores: opt: 255 z-score: 317.2 E(): 3.3e-10; 33.3% identity in 129 aa overlap.
 
 0.972
SCO2108
SC6E10.02, conserved hypothetical protein, len: 66 aa; unknown function, similar to e.g. SW:THIS_ECOLI (EMBL:M88701), ThiS, ThiG1, Escherichia coli hypothetical protein in thiamine biosynthetic operon (66 aa), fasta scores; opt: 138 z-score: 203.8 E(): 0.0005, 30.3% identity in 66 aa overlap and to TR:P96262 (EMBL:Z84724) Mycobacterium tuberculosis hypothetical protein (68 aa) (39.7% identity in 68 aa overlap).
  
 
 0.968
SCO2109
Putative thiazole biosynthesis protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.957
SCO5563
Phosphomethylpyrimidine kinase; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.
 
  
 0.946
SCO2104
Putative thiamin phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
  
 0.868
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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