STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO5460SC3D11.17, possible AbaA-like regulatory protein, len: 220 aa; similar to many from Streptomyces spp. e.g. TRNEW:AAD46514 (EMBL:AF145724) putative regulatory protein from Streptomyces albus (137 aa) fasta scores; opt: 258, z-score: 275.0, E(): 6.6e-08, 45.3% identity in 128 aa overlap and TR:Q53897 (EMBL:X60316) AbaA from Streptomyces coelicolor (192 aa) fasta scores; opt: 226, z-score: 240.9, E(): 5.3e-06, 32.3% identity in 189 aa overlap. (220 aa)    
Predicted Functional Partners:
SCO3066
SCE25.07c, putative regulator of Sig15, len: 170 aa; identical to previously sequenced TR:CAB55834 (EMBL:AJ249581) Streptomyces coelicolor A3(2) putative regulator of Sig15, 170 aa.
  
     0.766
SCO5459
SC3D11.16, probable enoyl-coA hydratase, len: 255aa; similar to many eg. SW:P52046 (CRT_CLOAB) 3-hydroxybutyryl-coa dehydratase from Clostridium acetobutylicum (261 aa) fasta scores; opt: 637, z-score: 725.4, E(): 5.4e-33, 43.4% identity in 249 aa overlap. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family and Prosite match to PS00166 Enoyl-CoA hydratase/isomerase signature.
       0.761
SCO5978
SCBAC16H6.13c, conserved hypothetical protein, len: 161aa: similar to many others in Streptomyces coelicolor eg. TR:Q9X7Q5 (EMBL:AL049587) hypothetical protein SC5F2A.32 (161 aa) fasta scores; opt: 222, Z-score: 255.7, 32.515% identity (36.054% ungapped) in 163 aa overlap. Also similar to TR:O69204 (EMBL:U33059) hypothetical protein from Actinosynnema pretiosum (subsp. auranticum) (144 aa) fasta scores; opt: 227, Z-score: 261.8, 39.735% identity (45.113% ungapped) in 151 aa overlap. Contains Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase.
  
     0.724
SCO1241
2SCG1.16c, conserved hypothetical protein, len: 170 aa; similar to TR:Q9X7Q5 (EMBL:AL049587) Streptomyces coelicolor hypothetical 17.1 kD protein, 161 aa; fasta scores: opt: 269 z-score: 295.6 E(): 5.3e-09; 39.4% identity in 132 aa overlap.
  
     0.665
SCO5915
Conserved hypothetical protein; SC10A5.20, unknown, len: 171 aa; weak similarity to part of TR:P79078 (EMBL:Y10421) DELTA-9 FATTY ACID DESATURA SE (EC 1.14.99.5) from CRYPTOCOCCUS CURVATUS (555 aa), fast a scores; opt: 83 z-score: 221.8 E(): 3.7e-05, 25.1% identi ty in 171 aa overlap.
  
   0.661
SCO3785
SCH63.32c, possible integral membrane protein, len: 409 aa; similar to TR:CAB95784 (EMBL:AL359949) Streptomyces coelicolor putative integral membrane protein 2SCG61.09, 387 aa; fasta scores: opt: 464 z-score: 500.7 E(): 2.3e-20; 32.5% identity in 379 aa overlap. Contains possible hydrophobic membrane spanning regions.
  
   0.625
SCO0872
Conserved hypothetical protein SCM1.05c; SCM1.05c, unknown, len: 445 aa. Weakly similar to several Streptomyces coelicolor proteins including: TR:O86807(EMBL:AL031031) putative regulatory protein SC7C7.02C (916 aa), fasta scores opt: 306 z-score: 336.6 E(): 2.1e-11 30.7% identity in 264 aa overlap and TR:CAB59599(EMBL:AL132662) hypothetical regulatory protein SCF11.22 (877 aa), fasta scores opt: 284 z-score: 312.7 E(): 4.5e-10 34.6% identity in 243 aa overlap. Contains a Pfam match to entry PF00072 response_reg, Response regulator receiver domain.
 
 
 0.617
SCO3971
SCBAC25E3.08c, conserved hypothetical protein, len: 477 aa: similar to many from Streptomyces coelicolor e.g. TR:Q9RJ90 (EMBL:AL132973) hypothetical protein SCF91.35 (884 aa) fasta scores; opt: 458, Z-score: 470.1, 31.210% identity (34.507% ungapped) in 471 aa overlap.
  
   0.583
SCO2560
Conserved hypothetical protein; SCC77.27c, unknown, len: 792 aa. Weakly similar to Streptomyces coelicolor TR:O86807 (EMBL:AL031031) putative regulatory protein SC7C7.02C (916 aa), fasta scores opt: 447 z-score: 376.3 E(): 1.4e-13 34.1% identity in 954 aa overlap. The N-terminus is also similar Streptomyces coelicolor TR:Q53897(EMBL:X60316) OrfA within the AbaA pleiotropic regulatory locus for antibiotic production (192 aa), fasta scores opt: 248 z-score: 220.6 E(): 6.7e-05 37.1% identity in 178 aa overlap.
  
   0.582
SCO0781
3SCF60.13, possible anti sigma factor antagonist, len: 166 aa; C-terminal region identical to TR:O85703 (EMBL:AF072709) Streptomyces lividans hypothetical 14.3 kDa protein, 128 aa and similar to SW:RSBV_STRCO (EMBL:AF134889) Streptomyces coelicolor anti-sigma B factor antagonist BldG, 113 aa; fasta scores: opt: 199 z-score: 266.9 E(): 2.4e-07; 31.5% identity in 108 aa overlap. Contains Pfam match to entry PF01740 STAS, STAS domain.
 
   0.575
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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