STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO5567SC7A1.11, possible DNA methylase, len: 195aa; similar to many hypotheticals some of which contain PS00092 N-6 Adenine-specific DNA methylases signature eg. SW:YHHF_ECOLI hypothetical protein from Escherichia coli (198 aa) fasta scores; opt: 340, z-score: 430.7, E(): 1.1e-16, (35.8% identity in 193 aa overlap). Contains PS00092 N-6 Adenine-specific DNA methylases signature although not in the expected N-terminal region. (195 aa)    
Predicted Functional Partners:
SCO5568
Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.
 
  
 0.980
SCO5566
Putative ATP-dependent DNA helicase; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily.
       0.809
SCO5565
SC7A1.09, unknown, len: 589 aa; similar to several hypothetical proteins eg.TR:O34751 (EMBL:Z99112) YLOV protein from Bacillus subtilis (553 aa) fasta scores; opt: 656, z-score: 464.3, E(): 1.4e-18, (28.9% identity in 582 aa overlap) and to TR:AAK47378 (EMBL:AE007126) Mycobacterium tuberculosis CDC1551 hypothetical protein MT3052, 470 aa; fasta scores: opt: 772 Z-score: 726.0 E(): 8.3e-33; 40.974% identity in 493 aa overlap.
 
     0.790
SCO5564
SC7A1.08c, rpmB, 50S ribosomal protein L28, len: 61aa; similar to many including SW:RL28_BACSU RpmB 50S ribosomal protein L28 from Bacillus subtilis (62 aa) fasta scores; opt: 171, z-score: 301.8, E(): 1.6e-09, (41.0% identity in 61 aa overlap). Contains Pfam match to entry PF00830 Ribosomal_L28, Ribosomal L28 family, score 74.50, E-value 2.2e-18; Belongs to the bacterial ribosomal protein bL28 family.
     
 0.698
SCO5573
formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).
 
     0.697
SCO5572
Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. May modulate key aspects of gene expression as its absence has extensive effects on the abundance of about 200 different transcripts. Probably processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. Belongs to the ribonuclease III family.
  
    0.696
SCO3882
Hypothetical protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family.
  
    0.681
SCO5570
Hypothetical protein; SC7A1.14, unknown, len: 217 aa; similar to Y06F_MYCTU hypothetical protein from Mycobacterium tuberculosis (207 aa) fasta scores; opt: 244, z-score: 699.9, E(): 1.1e-31, (45.5% identity in 189 aa overlap).
       0.678
SCO5571
SC7A1.15, rpmF, 50S ribosomal protein L32, len: 57 aa; similar to many eg. SW:RL32_BACST 50S PrmF, ribosomal protein L32 from Bacillus stearothermophilus (56 aa) fasta scores; opt: 180, z-score: 341.1, E(): 1.1e-11, (48.1% identity in 54 aa overlap).
       0.678
SCO1758
Putative GTP binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
 
    0.672
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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