STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO5943SC7H1.13, probable hydrolase, len: 261; weak similarity to several diverse hydrolases eg. TODF_PSEPU P23133 2-hydroxy-6-oxo-2,4-heptadienoate hydrolase (276 aa), fasta scores; opt: 196 z-score: 344.3 E(): 5.5e-12, 30.7% identity in 270 aa overlap. (261 aa)    
Predicted Functional Partners:
SCO5944
Hypothetical protein SC7H1.14; SC7H1.14, unknown, len: 382 aa.
 
     0.853
SCO5945
SC7H1.15, probable transferase, len: 606 aa; similar to TR:Q54353 (EMBL:X64651) S.lincolnensis lmbA gene for lincomycin condensing protein (601 aa), fasta scores; opt: 921 z-score: 1470.0 E(): 0, 45.8% identity in 600 aa overlap and to other gamma-glutamyl transferases.
 
   0.805
SCO5946
SC7H1.16, putative membrane protein, Gly-, Ala-rich protein, len: 257 aa. Contains possible hydrophobic membrane spanning regions.
 
     0.804
SCO5947
SC7H1.17, probable integral membrane protein, len: 465 aa; weakly similar to many eg. Mycobacterium tuberculosis TR:O07753 (EMBL:Z97193) MTCY180.41C (687 aa), fasta scores; opt: 440 z-score: 332.4 E(): 2.5e-11, 26.6% identity in 413 aa overlap. Contains possible hydrophobc membrane spanning regions.
 
     0.776
SCO5948
SC7H1.18, possible oxidoreductase, len: 397 aa; weak similarity to TCMG_STRGA P39888 tetracenomycin polyketide synthesis hydroxylase (572 aa), fasta scores; opt: 72 z-score: 275.1 E(): 4e-08, 26.0% identity in 369 aa overlap. Also similar to M. tuberculosis hypothetical protein Y08M_MYCTU Q11058 MTCY50.22c (372 aa), fasta scores; opt: 949 z-score: 613.3 E(): 5.8e-27, 45.9% identity in 355 aa overlap.
  
    0.742
SCO2886
SCE6.23c, possible hydrolase, len: 294 aa. Similar to several including: Mycobacterium sp. TR:Q9ZER0 (EMBL:AJ012627) haloalkane dehalogenase, DhaAF (307 aa), fasta scores opt: 347 z-score: 425.8 E(): 2.7e-16 27.4% identity in 292 aa overlap and Deinococcus radiodurans TR:AAF12090 (EMBL:AE002084) epoxide hydrolase-related protein (278 aa), fasta scores opt: 402 z-score: 493.2 E(): 4.8e-2032.4% identity in 284 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold.
  
     0.738
SCO5942
Hypothetical protein SC7H1.12; SC7H1.12, unknown, len: 205 aa; very weak similarity to downstream ORF SC7H1.21 (203 aa), (E(): 0.085, 26.9% identity in 208 aa overlap). Contains possible Helix-turn-helix motif at aa 41-62, Score 1089 (+2.90 SD).
 
     0.729
SCO0267
SCF1.09, possible hydrolase, len: 258 aa; similar to many e.g. TR:O67982 (EMBL:AF003947) 3-oxoadipate enol-lactone hydrolase from Rhodococcus opacus (400 aa) fasta scores; opt: 259, z-score: 300.,1 E(): 2.4e-09, (31.5% identity in 251 aa overlap). Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold.
  
     0.689
SCO3233
SCE29.02, probable hydrolase, len: 272 aa; similar to many e.g. TR:O52809 (EMBL:AJ223998) from the vancomycin biosynthesis cluster of Amycolatopsis orientalis (276 aa) fasta scores; opt: 892, z-score: 1028.9, E(): 0, (50.9% identity in 271 aa overlap) and TR:O67982 (EMBL:AF003947) PcaL; single polypeptide combining 3-oxoadipate enol-lactone hydrolyzing and 4-carboxymuconolactone decarboxylating activityfrom Rhodococcus opacus (400 aa) fasta scores; opt: 288, z-score: 335.4, E(): 2.3e-11, (32.0% identity in 256 aa overlap). Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hy [...]
  
     0.652
SCO7440
SC6D11.36c, possible hydrolase, len: 314 aa. Similar to several including Moraxella sp. SW:DEH1_MORSP (EMBL:D90422) haloacetate dehalogenase H-1 (EC 3.8.1.3) (294 aa). fasta scores opt: 356 z-score: 414.9 E(): 1.1e-15 27.9% identity in 297 aa overlap and Streptomyces coelicolor TR:O86546 (EMBL:AL031350) putative hydrolase, SC1F2.09C (309 aa), fasta scores opt: 498 z-score: 577.2 E(): 9.9e-25 35.2% identity in 307 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold.
  
     0.631
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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