STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
SCO6462Putative methylated-DNA-protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (164 aa)    
Predicted Functional Partners:
SCO6461
SC9B5.28, possible ADA-like regulatory protein, len: 490 aa; similar to SC1A9.14 (EMBL:AL034446) possible ADA-like regulatory protein from Streptomyces coelicolor (477 aa) fasta scores: opt: 1192, z-score: 937.1, E(): 0, (53.3% identity in 501 aa overlap). Also similar to ADA_MYCTU putative ADA regulatory protein from Mycobacterium tuberculosis (496 aa) fasta scores; opt: 2185, z-score: 2395.4, E(): 0, (66.7% identity in 490 aa overlap). Also note N-terminal region similar to N-terminal region of ADA_ECOLI ADA regulatory protein from Escherichia coli (354 aa) fasta scores; opt: 257, z- [...]
 
  
 0.895
SCO6150
SC1A9.14, possible ADA-like regulatory protein, len: 477 aa; similar to ADA_MYCTU (EMBL:Z73902) putative ADA regulatory protein from Mycobacterium tuberculosis (496 aa) fasta scores; opt: 1135, z-score: 1376.3, E(): 0, (51.6% identity in 486 aa overlap). Also note N-terminal region similar to N-terminal region of ADA_ECOLI (EMBL:M10211) ADA regulatory protein from Escherichia coli (354 aa) fasta scores; opt: 302, z-score: 255.8, E(): 5.7e-07, (34.5% identity in 171 aa overlap) and C-terminal region similar to 3MG2_ECOLI AlkA, 3-methyladenine DNA glycosylase II involved in DNA repair (2 [...]
  
 0.753
SCO6460
SC9B5.27, possible cation-transporting ATPase, len: 638aa; similar to many cation-transporting ATPases eg. SW:COPA_ENTHR copper /potassium-transporting= from Enterococcus hirae (727 aa) fasta scores: opt: 980, z-score: 936.0, E(): 0, (31.9% identity in 630 aa overlap). Contains PS00154 E1-E2 ATPases phosphorylation site and Pfam match to entry PF00122 E1-E2_ATPase, E1-E2 ATPases.
       0.730
SCO6459
SC9B5.26c, probable regulatory protein, len: 120aa; similar to many eg. TR:O69711 (EMBL:AL022121) putative regulatory protein from Mycobacterium tuberculosis (120 aa) fasta scores: opt: 480, z-score: 880.6, E(): 0, (63.2% identity in 117 aa overlap) and TR:O54057 (EMBL:AJ001934) nolR, negative regulator of nodulation genes in Rhizobium leguminosarum bv. viciae strain TOM (105 aa) fasta scores: opt: 156, z-score: 262.6, E(): 2.4e-07, (34.4% identity in 93 aa overlap). Contains Pfam match to entry PF01022 HTH_ARSR_family, Bacterial regulatory protein, arsR family corresponding to a proba [...]
       0.687
SCO6450
SC9B5.17, conserved hypothetical protein, len: 169 aa; similar to several hypothetical proteins eg. TR:Q44020 (EMBL:L36817) hypothetical protein from Alcaligenes eutrophus (173 aa) fasta scores; opt: 482, z-score: 757.7, E(): 0, (50.6% identity in 174 aa overlap). Also similar to TR:O75377 (EMBL:AF044286) histone macro 2A1.1 from Homo sapiens (369 aa) fasta scores; opt: 256, z-score: 321.4, E(): 1.3e-10, (29.4% identity in 170 aa overlap).
  
    0.581
SCO5143
SCP8.06, tag, DNA-3-methyladenine glycosylase I, len: 194 aa; highly similar to SW:3MG1_ECOLI (EMBL:J02606) Escherichia coli DNA-3-methyladenine glycosylase I (EC 3.2.2.20) Tag, 187 aa; fasta scores: opt: 529 z-score: 636.5 E(): 5.5e-28; 45.2% identity in 177 aa overlap.
   
 0.565
SCO6445
SC9B5.12, probable inositol monophosphatase, len: 281aa; similar to many eg. SW:MYO3_LYCES myo-inositol-1(or 4)-monophosphatase 3 from Lycopersicon esculentum (tomato) (268 aa) fasta scores; opt: 286, z-score: 396.1, E(): 9e-15, (30.9% identity in 275 aa overlap). Contains PS00629 Inositol monophosphatase family signature 1 and PS00630 Inositol monophosphatase family signature 2. Contains 2x Pfam match to entry PF00459 inositol_P, Inositol monophosphatase family.
       0.560
SCO2003
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 
 
 0.473
SCO4017
2SC10A7.21c, desR2, iron dependent repressor, len: 238 aa; highly similar to TR:CAB95905 (EMBL:AL359988) Streptomyces coelicolor iron repressor DesR, 230 aa; fasta scores: opt: 1140 z-score: 1122.3 E(): 0; 76.3% identity in 236 aa overlap and to SW:IDER_MYCTU (EMBL:U14191) Mycobacterium tuberculosis iron-dependent repressor IdeR, 230 aa; fasta scores: opt: 761 z-score: 754.0 E(): 0; 61.6% identity in 237 aa overlap. Contains Pfam match to entry PF01325 Fe_dep_repress, Iron dependent repressor.
     
 0.451
SCO6463
SC9B5.30, hypothetical protein, len: 289aa; similar to many eg. TR:O06216 (EMBL:Z95388) from Mycobacterium tuberculosis (288 aa) fasta scores: opt: 272, z-score: 302.0, E(): 1.6e-09, (30.1% identity in 259 aa overlap).
       0.441
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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