STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO6669SC5A7.19c, probable transcriptional regulator, len: 264 aa; similar to members of the iclR family e.g. GYLR_STRCO glycerol operon regulatory protein (254 aa), fasta scores; opt: 277 z-score: 318.0 E(): 1.8e-10, 31.4% identity in 245 aa overlap. Contains probable helix-turn-helix motif from aa 28-49 (Score 1240, +3.41 SD). (264 aa)    
Predicted Functional Partners:
SCO2544
SCC77.11, possible IclR-family transcriptional regulator, len: 265 aa. Similar to many other IclR-family regulators including: Escherichia coli SW:ICLR_ECOLI (EMBL:M31761) acetate operon repressor IclR (274 aa), fasta scores opt: 368 z-score: 447.5 E(): 1.5e-17 33.1% identity in 263 aa overlap and Erwinia carotovora subsp. carotovora TR:AAD50647 (EMBL:AF135396) regulator of virulence KdgR (263 aa), fasta scores opt: 326 z-score: 397.5 E(): 9.4e-15 29.7% identity in 239 aa overlap. Contains a possible N-terminal helix-turn-helix motif, situated between residues 36..57 (+4.94 SD) and a P [...]
  
     0.773
SCO7618
SC2H2.16, probable transcriptional regulator, len: 264 aa; similar to SW:GYLR_STRGR (EMBL:M37327) Streptomyces griseus glycerol operon regulatory protein GylR, 254 aa; fasta scores: opt: 270 z-score: 322.5 E(): 2e-10; 34.0% identity in 253 aa overlap. Contains Pfam match to entry PF01614 IclR, Bacterial transcriptional regulator and possible helix-turn-helix motif at residues 42..63 (+3.28 SD).
  
     0.770
SCO2935
SCE19A.35c, probable transcriptional regulator, len: 220 aa; similar to many e.g. SW:ICLR_ECOLI (EMBL:M31761), IclR, Escherichia coli acetate operon repressor (274 aa), fasta scores; opt: 206 z-score: 234.8 E(): 9.6e-06, 29.2% identity in 154 aa overlap. Similar to TR:O05148 (EMBL:U89712), hppR, Rhodococcus globerulus putative regulator of 3-(3-hydroxyphenyl)propionic acid catabolic pathway (206 aa) (44.8% identity in 174 aa overlap). Contains probable helix-turn-helix motif at aa 27-48 (Score 1663, +4.85 SD).
  
     0.731
SCO6667
SC5A7.17c, probable two-component regulator, len: 222 aa; highly similar to many e.g. DEGU_BACSU transcriptional regulatory protein DegU (229 aa), fasta scores; opt: 561 z-score: 630.7 E(): 7e-28, 44.0% identity in 225 aa overlap. Contains PS00622 Bacterial regulatory proteins, luxR family signature, probable helix-turn-helix motif from aa 173 to 194 (Score 1001, +2.60 SD) and Pfam matches to entry PF00072 response_reg, Response regulator receiver domain, score 124.10, E-value 2.7e-33 and entry PF00196 GerE, Bacterial regulatory proteins, luxR family, score 86.30, E-value 6.1e-22.
  
    0.711
SCO6668
SC5A7.18c, probable two-component sensor, len: 405 aa; similar in C-terminus to many e.g. NARQ_ECOLI nitrate.
       0.707
SCO2832
SCE20.06, possible IclR-family transcriptional regulator, len: 285 aa, Almost identical to a gene fragment which, like SCE20.06, is located upstream of the Streptomyces lividans lysT tRNA gene: TR:Q54411(EMBL:X52073) (200 aa), fasta scores opt: 1250 z-score: 1464.9 E():0 99.5% identity in 200 aa overlap. Also similar to Streptomyces coelicolor TR:Q9X9U3(EMBL:AL096823) putative transcriptional regulator (241 aa), fasta scores opt: 597 z-score: 704.2 E(): 7.7e-32 43.2% identity in 236 aa overlap. Contains a Pfam match to entry PF01614 IclR, Bacterial transcriptional regulator with a puta [...]
  
     0.704
SCO3925
SCQ11.08, probable transcriptional regulator, len: 241 aa; similar to many transcriptional regulators e.g. TR:Q43992 (EMBL:L05770), pobR, Acinetobacter calcoaceticus ADP1 transcriptional activator regulating expression of p-hydroxybenzoate hydroxylase (PobA) (271 aa), fasta scores; opt: 223 z-score: 262.9 E(): 2.6e-07, 25.9% identity in 239 aa overlap. Also similar to TR:O88025 (EMBL:AL031107) S.coelicolor probable transcriptional regulator (264 aa) (26.4% identity in 239 aa overlap). Contains probable helix-turn-helix motif at aa 19-40 (Score 1331, +3.72 SD) and possible hydrophobic m [...]
  
     0.685
SCO0442
Conserved hypothetical protein; SCF51A.20, unknown, len: 252 aa. Similar to a number of hypothetical proteins e.g. Escherichia coli SW:YBGJ_ECOLI (EMBL; AE000174) hypothetical 23.9 KD protein in phrB-nei intergenic region (218 aa), fasta scores: opt: 477 z-score: 492.1 E(): 4.7e-20 43.5% identity in 214 aa overlap.
  
    0.536
SCO6670
SC5A7.20, probable glucosidase, len: 441 aa; similar to e.g. CELF_ECOLI 6-phospho-beta-glucosidase (450 aa), fasta scores; opt: 537 z-score: 628.7 E(): 8.8e-28, 31.8% identity in 456 aa overlap.
       0.529
SCO0443
SCF51A.21, unknown, len: 285 aa. Similar to a number of hypothetical proteins e.g. Mycobacterium tuberculosis TR:P95220 (EMBL; Z86089) hypothetical 32.2 KD protein (300 aa), fasta scores opt: 714 z-score: 663.0 E(): 1.4e-29 45.3% identity in 289 aa overlap. Also similar in parts to Pseudomonas fluorescens TR:CAB48407 (EMBL; AJ243652) urea amidolyase homologue (1213 aa), fasta scores opt: 423 z-score: 390.1 E(): 2.3e-14 37.7% identity in 289 aa overlap.
  
    0.528
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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