STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO6810Conserved hypothetical protein; SC1A2.19c, unknown, len: 152 aa. Highly similar to proteins of undefined function from Mycobacterium tuberculosis SW:YQ11_MYCTU (EMBL:Z80225) (152 aa), fasta scores opt: 509 z-score: 630.7 E(): 1e-27 55.0% identity in 149 aa overlap and Bacillus subtilis SW:YQCK_BACSU (EMBL:D32216) (146 aa), fasta scores opt:349 z-score: 437.2 E():6e-17 34.9% identity in 152 aa overlap. (152 aa)    
Predicted Functional Partners:
SCO6809
SC1A2.18c, possible integral membrane transport protein, len: 409 aa. Similar to several membrane transport proteins e.g. Listeria monocytogenes TR:Q9X769 (EMBL:AJ009627) multi drug resistance transporter (397 aa), fasta scores opt: 241 z-score: 264.5 E(): 2.5e-07 23.0% identity in 344 aa overlap. Contains multiple possible membrane spanning hydrophobic domains and a Prosite hit to PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
       0.773
SCO6811
Putative secreted protein; SC1A2.20c, possible secreted protein, len: 464 aa. The N-terminus is highly similar to Streptomyces coelicolor TR:Q9X8X7 (EMBL:AL078610) putative secreted protein, SCH35.29 (162 aa), fasta scores opt: 753 z-score: 813.4 E(): 0 71.2% identity in 146 aa overlap. Contains a possible N-terminal signal sequence.
       0.650
SCO6808
SC1A2.17c, possible ArsR-family transcriptional regulator, len: 120 aa. Similar to several regulators including: Streptomyces coelicolor TR:Q9X8X8 (EMBL:AL078610) putative transcriptional regulator, SCH35.28C (122 aa), fasta scores opt: 297 z-score: 392.7 E(): 1.8e-14 49.4% identity in 87 aa overlap and Mycobacterium tuberculosis TR:P71941 (EMBL:Z80225) putative transcriptional regulator (126 aa), fasta scores opt: 262 z-score: 348.0 E(): 5.6e-12 38.1% identity in 113 aa overlap. Contains a Pfam match to entry PF01022 HTH_5, Bacterial regulatory protein, arsR family with the putative h [...]
 
  
 0.573
SCO4603
NADH dehydrogenase subunit NuoI2; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
 
  
 0.561
SCP1.270
Hypothetical protein; SCP1.270, unknown, doubtful CDS, len: 96aa.
       0.531
SCO4570
NuoI, NADH dehydrogenase subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
  
  
 0.503
SCO4858
SC5G8.26c, dhsC, possible succinate dehydrogenase membrane subunit, len: 126aa; similar to many eg. TR:O53368 (EMBL:AL021841) putative membrane anchor of succinate dehydrogenase from Mycobacterium tuberculosis (112 aa) fasta scores; opt: 484, z-score: 649.2, E(): 1e-28, 65.7% identity in 99 aa overlap. Also wealky similar to SW:P10446 (DHSC_ECOLI) succinate dehydrogenase cytochrome b-556 subunit from Escherichia coli (129 aa) fasta scores; opt: 121, z-score: 173.9, E(): 0.031, 29.6% identity in 71 aa overlap. Contains Pfam match to entry PF01127 Sdh_cyt, Succinate dehydrogenase cytochr [...]
   
  
 0.498
SCO6812
SC1A2.21, possible ArsR-family transcriptional regulator, len: 119 aa. Highly similar to several including: Streptomyces coelicolor TR:Q9X8X8 (EMBL:AL078610) putative transcriptional regulator, SCH35.28C (122 aa), fasta scores opt: 485 z-score: 630.1 E(): 1.1e-27 69.7% identity in 99 aa overlap and Mycobacterium tuberculosis TR:P71941 (EMBL:Z80225) putative transcriptional regulator (126 aa), fasta scores opt:378 z-score: 494.4 E(): 3.9e-20 59.8% identity in 97 aa overlap. Also similar to the adjoining CDS SC1A2.22 (113 aa), fasta scores opt: 292 z-score: 353.0 E(): 3.1e-14 51.1% ident [...]
 
  
 0.497
SCO1310
SCBAC36F5.21, possible cation efflux system protein, len: 363 aa; similar to TR:AAK46363 (EMBL:AE007059) Mycobacterium tuberculosis CDC1551 MT2084, 332 aa; fasta scores: opt: 1199 Z-score: 1252.9 bits: 240.3 E(): 3.6e-62; 59.627% identity in 322 aa overlap. Contains Pfam match to entry PF01545 Cation_efflux, Cation efflux family and possible hydrophobic membrane spanning regions; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family.
   
  
 0.447
SCO6712
SC4C6.22, possible copper oxidase, len: 343 aa; weakly similar to members of the multicopper oxidase family e.g. to the N-terminus of SW:COPA_PSESM (EMBL:M19930), CopA, Pseudomonas syringae copper resistance protein A precursor (609 aa), fasta scores; opt: 170 z-score: 188.4 E(): 0.0036, 27.3% identity in 205 aa overlap. Also weakly similar to the blood coagulation factors which are structurally related to the multicopper oxidases. Similar to the N-terminus of TR:O53858 (EMBL:AL022004) Mycobacterium tuberculosis hypothetical protein (504 aa) (25.1% identity in 323 aa overlap). Contains [...]
     
 0.446
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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