STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO6953Conserved hypothetical protein SC6F7.06c; SC6F7.06c, unknown, len: 525 aa; low similarity to Streptomyces coelicolor SCP1 plasmid borne TR:Q9ACU9 (EMBL:AL590464) Streptomyces coelicolor hypothetical protein SCP1.204c, 553 aa; fasta scores: opt: 617 Z-score: 687.1 E(): 1.2e-30; 29.916% identity in 478 aa overlap. (525 aa)    
Predicted Functional Partners:
SCO3997
SCBAC25E3.34, possible integrase, len: >380aa: similar to many eg. SW:P22884 (VINT_BPML5) integrase int from Mycobacteriophage L5 (371 aa) fasta scores; opt: 448, Z-score: 506.7, 29.111% identity (31.304% ungapped) in 371 aa overlap. Contains Pfam match to entry PF00589 Phage_integrase, Phage integrase family.
      
 0.872
SCO6806
Putative phage integrase; SC1A2.15c, possible phage integrase, len: 405 aa. Weakly similar to Corynephage 304L TR:Q9ZWV7 (EMBL:Y18058) integrase (395 aa), fasta scores opt: 190 z-score: 224.2 E(): 4.4e-05 24.6% identity in 391 aa overlap and Streptomyces coelicolor TR:Q9Z4Y1 (EMBL:AL035707) putative integrase, SCE29.19C (384 aa), fasta scores opt: 191 z-score: 225.6 E(): 3.7e-05 27.4% identity in 358 aa overlap. Contains a Pfam match to entry PF00589 Phage_integrase, Phage integrase family.
      
 0.792
SCO6951
Conserved hypothetical protein; SC6F7.04, unknown, len: 293 aa. Similar to Streptomyces coelicolor TR:Q9ZEP2(EMBL:AJ131213) hypothetical 30.7 kd protein, SCE94.11C (277 aa), fasta scores: opt: 214 z-score: 251.4 E(): 1.5e-06 26.6% identity in 286 aa overlap.
      
 0.646
SCO4617
SCD39.17c, possible ATP-binding protein, len: 490 aa. Contains match to Prosite entry and PS00017 ATP/GTP-binding site motif A (P-loop).
      
 0.510
SCO4618
Hypothetical protein SCD39.18c; SCD39.18c, unknown, len: 283 aa.
      
 0.510
SCO5347
SCBAC5H2.16, repSA2, replication initiation protein, len: 454 aa; highly similar to plasmid borne SW:REPS_STRAM (EMBL:Z19594) Streptomyces ambofaciens replication initiation protein repSA, 459 aa; fasta scores: opt: 2806 z-score: 3256.0 E(): 0; 90.8% identity in 446 aa overlap and to TR:Q9X8C5 (EMBL:AL049573) Streptomyces coelicolor replication initiation protein repSA, 466 aa; fasta scores: opt: 2759 z-score: 3201.4 E(): 0; 88.1% identity in 453 aa overlap.
      
 0.506
SCO3125
peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.
      
 0.483
SCO3257
SCE39.07c, traSA, plasmid transfer protein, len: 451 aa; similar to many from Streptomyces spp. eg. TR:O69803 (EMBL:AJ005260) from the integrated conjugative plasmid pSAM2 of Streptomyces ambofaciens (415 aa) fasta scores; opt: 2515, z-score: 2911.8, E(): 0, (90.6% identity in 415 aa overlap) and TR:O86766 (EMBL:AL031035) TraSA integrase fusion protein from the Streptomyces coelicolor cosmid 6A9 (768 aa) fasta scores; opt: 2418, z-score: 2795.6, E(): 0, (89.1% identity in 405 aa overlap). Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). Also contains strongly hy [...]
      
 0.483
SCO3259
SCE39.09c, korSA, regulatory protein, len: 259 aa; highly similar to TR:Q07191 (EMBL:AJ005260) KorSA, regulatory protein from the integrated conjugative plasmid pSAM2 of Streptomyces ambofaciens (259 aa) fasta scores; opt: 1669, z-score: 1948.2, E(): 0, (98.5% identity in 259 aa overlap) and TR:O86763 (EMBL:AL031035) regulatory protein from Streptomyces coelicolor cosmid SC6A9 (259 aa) fasta scores; opt: 1655, z-score: 1931.9, E(): 0, (96.9% identity in 259 aa overlap). Contains Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family.
      
 0.483
SCO5636
SC6A9.31, korSA, transcriptional regulator, len: 259 aa; almost identical to TR:E1286465 (EMBL:AJ005260) KorSA from Streptomyces ambofaciens plasmid pSAM2 (259 aa); 98.5% identity in 259 aa overlap and similar to many members of the gntR family e.g. KORA_STRLI KorA protein (241 aa), fasta scores; opt: 187 z-score: 247.3 E(): 1.6e-06, 26.7% identity in 240 aa overlap. Contains Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family, score 61.80, E-value 1.6e-17.
      
 0.483
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.