STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO7143SC9A4.05, probable transcriptional regulator, len: 937 aa; similar to TR:CAB89765 (EMBL:AL354616) Streptomyces coelicolor putative transcriptional regulator SC3A4.19, 932 aa; fasta scores: opt: 2131 z-score: 2221.3 E(): 0; 43.6% identity in 928 aa overlap. Contains Pfam match to entry PF00196 GerE, Bacterial regulatory proteins, luxR family and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop). Also contains helix-turn-helix motif at residues 881..902 (+3.88 SD). (937 aa)    
Predicted Functional Partners:
SCO7134
SC4B10.35, probable transcriptional regulatory protein, len: 923 aa; similar to TR:Q9S1Z4 (EMBL:AL109747) Streptomyces coelicolor probable transcriptional regulator SCJ21.13, 919 aa; fasta scores: opt: 2675 z-score: 2853.2 E(): 0; 50.6% identity in 926 aa overlap. Contains Pfam match to entry PF00196 GerE, Bacterial regulatory proteins, luxR family and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop). Also contains possible helix-turn-helix motif at residues 876..897 (+3.18 SD).
 
 
  
0.681
SCO0132
SCJ21.13, probable transcriptional regulator, len: 919 aa; similar to many e.g. TR:AAD28307 (EMBL:U95170) Rhodococcus erythropolis ThcG (927 aa), fasta scores; opt: 1176 z-score: 1258.4 E(): 0, 34.2% identity in 933 aa overlap, and TR:AAA53487 (EMBL:U03114) Streptomyces albus LipR (890 aa), fasta scores; opt: 740 z-score: 791.4 E(): 0, 31.1% identity in 952 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop), Pfam match to entry PF00196 GerE, Bacterial regulatory proteins, luxR family, and probable helix-turn-helix motif at aa 871-892 (Score 1389, +3.92 SD).
 
 
  
0.676
SCO7144
SC9A4.06, possible ECF sigma factor, len: 245 aa; similar to TR:Q9RDI5 (EMBL:AL136519) Streptomyces coelicolor putative sigma factor SCC57A.13c, 315 aa; fasta scores: opt: 395 z-score: 475.1 E(): 5.3e-19; 35.0% identity in 197 aa overlap and to SW:RPSH_PSEAE (EMBL:L14760) Pseudomonas aeruginosa RNA polymerase sigma-H factor AlgU, 193 aa; fasta scores: opt: 143 z-score: 180.2 E(): 0.014; 26.0% identity in 177 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily).
     
 0.491
SCO7173
SC8A11.01, possible transcriptional regulator (fragment), len: >750 aa; similar to TR:Q9S1Z4 (EMBL:AL109747) Streptomyces coelicolor probable transcriptional regulator SCJ21.13, 919 aa; fasta scores: opt: 818 z-score: 913.7 E(): 0; 32.6% identity in 775 aa overlap. Contains Pfam match to entry PF00196 GerE, Bacterial regulatory proteins, luxR family and match to Prosite entry PS00622 Bacterial regulatory proteins, luxR family signature. Also contains a possible helix-turn-helix motif at residues 699..720 (+3.25 SD); SC9A4.35, possible regulatory protein (fragment), len: >191 aa; simila [...]
 
 
0.488
SCO5748
SC7C7.03, probable sensory histidine kinase, len: 1829 aa; N-terminus has 11 92aa repeats. Highly similar to putative osmosensing histidine kinases from yeasts (with only five repeats) e.g. Neurospora crassa TR:Q01318 (EMBL:U53189) osmotic-1 locus putative histidine kinase (1298 aa), fasta scores; opt: 2011 z-score: 1764.6 E(): 0, 38.3% identity in 1281 aa overlap. Also similar to BARA_ECOLI sensor protein BarA (918 aa) (with only one copy of the repeat), fasta scores; opt: 378 z-score: 755.8, E(): 0, 28.9% identity in 619 aa overlap. Extreme N-terminus has similarity to the phosphoryl [...]
  
 
 0.478
SCO2893
Conserved hypothetical protein SCE6.30c; SCE6.30c, unknown, len: 277 aa. Similar to several proteins of undefined function e.g. Mycobacterium leprae TR:Q9Z5H1(EMBL:AL035500) hypothetical 22.1 kd protein (200 aa), fasta scores opt: 413 z-score: 443.6 E(): 2.8e-17 41.5% identity in 205 aa overlap. Contains a possible coiled-coil between residues 206..226.
  
     0.476
SCO6827
SC4A9.04c, polyketide synthase, len: 2358 aa. Highly similar to many including: Stigmatella aurantiaca TR:AAF19813(EMBL:AF188287) polyketide synthase, MtAE, found within the Myxothiazol biosynthetic gene cluster (1947 aa), fasta scores opt: 2671 z-score: 2436.5 E():0 35.8% identity in 1770 aa overlap and Mycobacterium tuberculosis SW:PPSA_MYCTU(EMBL:Z74697) phenolpthiocerol synthesis polyketide synthase gene, PpsA (1876 aa), fasta scores opt: 2221 z-score: 2025.5 E(): 0 33.6% identity in 1761 aa overlap. Contains Prosite hits to PS00606 Beta-ketoacyl synthases active site and 2xPS00012 [...]
  
  
 0.463
SCO5065
SCBAC20F6.08c, possible transcriptional regulator, len: 943 aa; similar to many putative transcriptional regulatory proteins, e.g. TR:Q9XAT8 (EMBL:U95170) Rhodococcus erythropolis ThcG, 927 aa; fasta scores: opt: 1419 Z-score: 1371.5 bits: 265.1 E(): 8.4e-69; 35.446% identity in 931 aa overlap. Contains Pfam match to entry PF00196 GerE, Bacterial regulatory proteins, luxR family and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00622 Bacterial regulatory proteins, luxR family signature. Also contains possible helix-turn-helix motif at residues 893..914 [...]
 
 
0.462
SCO7142
SC9A4.04, hypothetical protein, len: 133 aa; similar to SW:YODB_BACSU (EMBL:AF006665) Bacillus subtilis hypothetical 12.8 kDa protein in OdhA-CtpA intergenic region YodB, 112 aa; fasta scores: opt: 258 z-score: 328.5 E(): 7.9e-11; 44.0% identity in 91 aa overlap. Contains Pfam match to entry PF01638 DUF24, Protein of unknown function DUF24.
       0.443
SCO6993
SC8F11.19, absR2, regulatory protein, len: 606 aa. Shares 98.8 % sequence identity with that previously sequenced: Streptomyces coelicolor TR:AAF19103 (EMBL:AF136167) putative repressor of secondary metabolism, AbsR2. Contains a PS00017 ATP/GTP-binding site motif A (P-loop) and a Pfam match to entry PF00196 GerE, Bacterial regulatory proteins, luxR family, with a putative helix-turn-helix motif situated between residues 559..580 (+4.00 SD).
 
   0.430
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (18%) [HD]