STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO7264SC5H1.28c, probable oxidoreductase, len: 305 aa; similar to many e.g. SW:MORA_PSEPU (EMBL:Q02198), morA, Pseudomonas putida morphine 6-dehydrogenase (295 aa), fasta scores; opt: 235 z-score: 281.5 E(): 2.3e-08, 28.1% identity in 274 aa overlap. (305 aa)    
Predicted Functional Partners:
SCO0429
SCF51A.07c, possible oxidoreductase, len: 315 aa. Weakly similar to many eukaryotic oxidoreductases e.g. Hordeum vulgare (Barley) TR:Q42837 (EMBL; Z48360) aldose reductase (EC 1.1.1.21) (aldehyde reductase) (320 aa), fasta scores opt: 236 z-score: 263.3 E(): 2.6e-07 27.0% identity in 296 aa overlap and many other putative oxidoreductases e.g. Streptomyces coelicolor TR:CAB42953 (EMBL:AL049863) putative oxidoreductase SC5H1.28C (305 aa), fasta scores opt: 563 z-score: 617.0 E(): 5.2e-27 39.7% identity in 305 aa overlap.
  
  
 
0.916
SCO0299
SC5G9.08, possible oxidoreductase, len: 294 aa; shows weak similarity to TR:P06632 (EMBL:M12799) Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase (278 aa), fasta scores; opt: 196 z-score: 229.3 E(): 2.1e-05, 27.6% identity in 286 aa overlap. Similar to many hypothetical oxidoreductases e.g. SW:YDBC_ECOLI (EMBL:X62680), YbcD, Escherichia coli hypothetical oxidoreductase (286 aa) (63.3% identity in 283 aa overlap). Also similar to SC5H1.28C (EMBL:AL049863) Streptomyces coelicolor putative oxidoreductase (305 aa) (46.5% identity in 301 aa overlap).
  
  
 
0.909
SCO3730
SCH22A.08, possible oxidoreductase, len: 285 aa; similar to TR:Q9X7T6 (EMBL:AL049863) Streptomyces coelicolor putative oxidoreductase SC5H1.28c, 305 aa; fasta scores: opt: 778 z-score: 848.8 E(): 0; 52.1% identity in 288 aa overlap.
  
  
 
0.908
SCO4387
Putative pyridoxamine oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
     
  0.900
SCO4418
SC6F11.16c, probable oxidase, len: 222 aa; similar to TR:O88794 (EMBL:U91561) Rattus norvegicus pyridoxine 5'-phosphate oxidase PnpO, 261 aa; fasta scores: opt: 413 z-score: 479.7 E(): 3.2e-19; 38.0% identity in 184 aa overlap. Contains Pfam match to entry PF01243 Pyridox_oxidase, Pyridoxamine 5'-phosphate oxidase.
     
  0.900
SCO7263
Chitinase; SC5H1.29c, chiF, chitinase, len: 296 aa; previously sequenced as chiF (EMBL:AB017012) and similar to many e.g. TR:O50152 (EMBL:AB009289), chiC, Streptomyces griseus chitinase C (294 aa), fasta scores; opt: 1308 z-score: 1506.5 E(): 0, 65.8% identity in 295 aa overlap. Contains possible N-terminal signal sequence. Contains Pfam match to entry PF00182 chitinase_1, Chitinases class I, score 247.20, E-value 2.2e-70.
       0.757
SCO1670
SCI52.12, possible oxidoreductase, len: 328 aa; similar to TR:Q44328 (EMBL:AF242881) Agrobacterium radiobacter MocA protein, 354 aa; fasta scores: opt: 708 Z-score: 822.0 bits: 160.5 E(): 3.3e-38; 41.246% identity in 337 aa overlap.
  
     0.679
SCO7087
Putative oxidoreductase; SC3A4.13c, possible oxidoreductase, len: 312 aa. Similar to many including: Streptomyces coelicolor TR:CAB61562(EMBL:AL133171) putative aldo/keto reductase (fragment), SCF81.28C (307 aa), fasta scores opt: 351 z-score: 407.7 E():3e-15 30.7% identity in 309 aa overlap.
  
     0.615
SCO4339
SCD12A.22c, possible reductase, len: 284 aa; similar to SW:STCV_EMENI (EMBL:U34740) Aspergillus nidulans putative sterigmatocystin biosynthesis dehydrogenase StcV, 387 aa; fasta scores: opt: 401 z-score: 462.6 E(): 2.6e-18; 32.0% identity in 284 aa overlap and to TR:O33936 (EMBL:U77454) Saccharopolyspora erythraea EryBII, 333 aa; fasta scores: opt: 970 z-score: 1111.9 E(): 0; 53.7% identity in 287 aa overlap.
 
     0.508
SCO7356
Oxidoreductase; SC9H11.10c, oxidoreductase, len: 276 aa. Highly similar to many including: Corynebacterium sp. SW:2DKG_CORSP(EMBL:M21193) 2,5-diketo-d-gluconic acid reductase (EC 1.1.1.-) (277 aa), fasta scores opt: 1006 z-score: 1188.8 E(): 0 52.9% identity in 274 aa overlap and Streptomyces coelicolor TR:Q9ZBW7(EMBL:AL034443;) putative oxidoreductase, SC4B5.01C (277 aa), fasta scores opt: 1018 z-score: 1202.9 E():0 56.3% identity in 268 aa overlap. Contains Prosite hits to PS00063 Aldo/keto reductase family putative active site signature, PS00062 Aldo/keto reductase family signature [...]
 
 
0.466
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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