STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO7405Putative acetyltransferase (fragment); SC6D11.01c, possible acetyltransferase, partial CDS, len: > 72 aa. Similar to the N-terminus of Escherichia coli SW:THGA_ECOLI(EMBL:J01636) galactoside O-acetyltransferase (EC 2.3.1.18) (203 aa), fasta scores opt: 138 z-score: 187.9 E(): 0.0048 38.3% identity in 60 aa overlap. Overlaps and extends into CDS SC10G8.33c on the adjoining cosmid.; SC10G8.33c, possible acetyltransferase, partial CDS, len: > 175 aa. Highly similar to a number of acetyltransferases e.g. Escherichia coli SW:THGA_ECOLI(EMBL:J01636) galactoside o-acetyltransferase (EC 2.3.1. [...] (215 aa)    
Predicted Functional Partners:
SCO1238
Putative ATP-dependent Clp protease; Has lost one of the conserved residue (Ser) proposed to be part of the active site. Therefore it could be inactive.
   
  
 0.676
SCO6754
SC6A5.03, possible glycerol dehydrogenase, len: 340aa; similar to many eg. SW:GLDA_PSEPU glycerol dehydrogenase, GldA, from Pseudomonas putida (365 aa) fasta scores; opt: 261, z-score: 303.7, E(): 1.3e-09, (27.9% identity in 308 aa overlap).
      
 0.657
SCO6408
SC3C8.27c, clpA, probable clp protease ATP binding subunit, len: 842 aa; highly similar to many e.g. CLPB_ECOLI clpB protein (857 aa), fasta scores; opt: 975 z-score: 1914.6 E(): 0, 46.8% identity in 857 aa overlap anCLAB_LYCES ATP-dependent clp protease atp-binding subunit (923 aa), fasta scores; opt: 2335 z-score: 2174.3 E(): 0, 50.3% identity in 758 aa overlap. Contains 2x PS00017 ATP/GTP-binding site motif A (P-loop), PS00870 and PS00871 Chaperonins clpA/B signatures 1 and 2, Pfam match to entry clpA_B PF00495, Chaperonins clpA/B, score 1127.99 and probable coiled-coil from aa 432 [...]
   
  
 0.653
SCO3556
SCH5.19c, possible secretory protein, len: 523 aa; similar to many of undefined function eg. TR:O69627 (EMBL:AL022121) hypothetical protein from Mycobacterium tuberculosis (352 aa) fasta scores; opt: 1287, z-score: 1191.3, E(): 0, (59.8% identity in 351 aa overlap) and SW:TRBB_AGRT6 conjugal transfer protein from Agrobacterium tumefaciens (323 aa) fasta scores; opt: 469, z-score: 441.4, E(): 2.8e-17, (31.4% identity in 287 aa overlap). Contains Pfam match to entry PF00437 GSPII_E, Bacterial type II secretion system protein, score 41.30, E-value 1.6e-11. Also contains PS00017 ATP/GTP-bi [...]
      
 0.645
SCO5009
SCK15.11, probable secretory protein, len: 445 aa; similar to TR:P94647 (EMBL:U77780) Chlorobium limicola secretory protein kinase Kbh, 474 aa; fasta scores: opt: 1192 z-score: 1311.8 E(): 0; 47.7% identity in 396 aa overlap, to SW:TRBB_AGRT6 (EMBL:U43675) Agrobacterium tumefaciens conjugal transfer protein TrbB, 323 aa; fasta scores: opt: 512 z-score: 568.9 E(): 3.2e-24; 30.4% identity in 326 aa overlap and to TR:Q9X921 (EMBL:AL035636) Streptomyces coelicolor putative secretory protein SCH5.19c, 523 aa; fasta scores: opt: 878 z-score: 847.4 E(): 0; 40.3% identity in 365 aa overlap. Co [...]
      
 0.645
SCO5746
Hypothetical protein SC7C7.01; SC7C7.01, unknown, len: 225 aa; some similarity to hydrophobic region from B. subtilis DEGT_BACST pleiotropic regulatory protein (372 aa), fasta scores; opt: 289 z-score: 450.7 E(): 7.2e-18, 51.7% identity in 89 aa overlap. Also similar to e.g. TR:P72452 (EMBL:Y00459) aminotransferase from Streptomyces griseus(378 aa), fasta scores; opt: 250 z-score: 429.3 E(): 1.1e-16, 29.4% identity in 309 aa overlap.
  
  
 0.550
SCO7406
Putative secreted protein; SC6D11.02C, possible secreted protein, len: 691 aa. Contains a 8xGT repeat region within the C-terminus and a possible N-terminal signal sequence.
       0.545
SCO4182
Conserved hypothetical protein; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family.
     
 0.533
SCO1804
Putative S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
     
 0.518
SCO7404
Conserved hypothetical protein SC10G8.32c; SC10G8.32c, unknown, len: 263 aa. Highly similar to a number of proteins of undefined function from Streptomyces coelicolor including: TR:O86541 (EMBL:AL031350) SC1F3.04 (261 aa), fasta scores opt: 1155 z-score: 1354.8 E():0 67.9% identity in 262 aa overlap and TR:O86718 (EMBL:AL031515) SC5C7.21C (271 aa), fasta scores opt: 894 z-score: 1050.3 E(): 0 54.0% identity in 272 aa overlap.
       0.513
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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