STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO7475SCBAC17A6.08, possible phenylacetic acid degradation NADH oxidoreductase PaaE, len: 368 aa; similar to many e.g. SW:P76081 (PAAE_ECOLI) probable phenylacetic acid degradation NADH oxidoreductase PaaE from Escherichia coli (356 aa) fasta scores; opt: 871, Z-score: 943.6, 39.943% identity (40.870% ungapped) in 353 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains; Pfam match to entry PF00175 NAD_binding, Oxidoreductase FAD/NAD-binding domain; Pfam match to entry PF00970 FAD_binding_6, Oxidoreductase FAD-binding domain and Prosite match to P [...] (368 aa)    
Predicted Functional Partners:
SCO7472
SCBAC17A6.05, possible phenylacetic acid degradation protein PaaB, len: 103 aa: similar to many e.g. SW:P76078 (PAAB_ECOLI) phenylacetic acid degradation protein PaaB from Escherichia coli (95 aa) fasta scores; opt: 427, Z-score: 565.4, 66.667% identity (66.667% ungapped) in 90 aa overlap.
 
 
 0.998
SCO7473
SCBAC17A6.06, possible phenylacetic acid degradation protein PaaC, len: 275 aa: similar to many e.g. SW:P76079 (PAAC_ECOLI) phenylacetic acid degradation protein PaaC from Escherichia coli (248 aa) fasta scores; opt: 470, Z-score: 547.8, 41.057% identity (44.105% ungapped) in 246 aa overlap.
 
 0.998
SCO7474
SCBAC17A6.07, possible phenylacetic acid degradation protein PaaD, len: 170 aa: similar to many e.g. SW:P76080 (PAAD_ECOLI) phenylacetic acid degradation protein PaaD from Escherichia coli (167 aa) fasta scores; opt: 474, Z-score: 518.6, 45.395% identity (47.586% ungapped) in 152 aa overlap. Contains Pfam match to entry PF01883 DUF59, Domain of unknown function DUF59.
 
 
 0.998
SCO7471
SCBAC17A6.04, possible phenylacetic acid degradation protein PaaA, len: 328 aa: similar to many e.g. SW:P76077 (PAAA_ECOLI) phenylacetic acid degradation protein PaaA from Escherichia coli (309 aa) fasta scores; opt: 1540, Z-score: 1801.2, 69.967% identity (69.967% ungapped) in 303 aa overlap.
 
 0.997
SCO7470
SCBAC17A6.03c, possible phenylacetic acid degradation protein PaaI, len: 170 aa: similar to many e.g. SW:P76084 (PAAI_ECOLI) phenylacetic acid degradation protein PaaI from Escherichia coli (140 aa) fasta scores; opt: 342, Z-score: 414.6, 45.902% identity (46.281% ungapped) in 122 aa overlap. Contains Pfam match to entry PF02584 DUF157, Uncharacterized protein PaaI.
 
 
  0.994
SCO7469
phenylacetate-CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).
 
 
 0.992
SCO6560
SC4B5.10c, respiratory chain oxidoreductase, len: 646 aa; C-terminal region is similar to the N-terminal region of many proteins involved in electron transfer e.g. TR:O27592 (EMBL:AE000915) NADP-reducing hydrogenase, subunit C from Methanobacterium thermoautotrophicum (630 aa), fasta scores; opt: 121,4 z-score: 1170.7, E(): 0, (47.1% identity in 397 aa overlap). Contains PS00645 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2.
  
 
 0.962
SCO5144
SCP8.07c, probable acyl CoA isomerase, len: 267 aa; highly similar to TR:AAF73478 (EMBL:AF268489) Streptomyces collinus 2-cyclohexenylcarbonyl CoA isomerase ChcB, 269 aa; fasta scores: opt: 1476 z-score: 1623.5 E(): 0; 87.6% identity in 266 aa overlap and to SW:CRT_CLOAB (EMBL:U17110) Clostridium acetobutylicum 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55) Crt, 261 aa; fasta scores: opt: 426 z-score: 476.6 E(): 4.4e-19; 32.4% identity in 259 aa overlap. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family and match to Prosite entry PS00166 Enoyl-CoA hydratase [...]
 
 
 0.931
SCO2157
SC6G10.30, probable aminotransferase, len: 460 aa; similar to many NifS-like proteins e.g. SW:NIFS_RHOSH NifS protein from Rhodobacter sphaeroides (387 aa) fasta scores; opt: 702, z-score: 760.5, E(): 0, (37.4% identity in 390 aa overlap). Contains Pfam matches to entry PF00266 aminotran_5, Aminotransferases class-V and entry PF01206 UPF0033, Uncharacterized protein family UPF0033; Belongs to the sulfur carrier protein TusA family.
  
 0.918
SCO1920
SCC22.02c, conserved hypothetical protein, len: 156aa; similar to many other hypothetical protein eg. TR:O53156 (EMBL:AL021184) hypothetical protein from Mycobacterium tuberculosis (162 aa) fasta scores; opt: 569, z-score: 685.8, E(): 7.2e-31, (56.3% identity in 158 aa overlap) and to SW:NIFU_BACSU (EMBL:Z99120) Bacillus subtilis NifU-like protein NifU, 147 aa; fasta scores: opt: 439 Z-score: 527.7 E(): 9.3e-22; 45.517% identity in 145 aa overlap.
  
 0.899
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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