STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO7709SCBAC12C8.10, possible MarR-family transcriptional regulator, len: 142 aa: similar to many e.g. TR:Q9F3P8 (EMBL:AL450350) putative MarR-family regulatory protein SC10F4.12 from Streptomyces coelicolor fasta scores; opt: 337, Z-score: 398.2, 46.923% identity in 130 aa overlap. Contains Pfam match to entry PF01047 MarR, MarR family. (142 aa)    
Predicted Functional Partners:
SCO5413
SC8F4.17, possible transcriptional regulator, len: 169 aa; similar to many proposed transcriptional regulators e.g. TR:CAB62730 (EMBL:AL133423) putative MarR-family transcriptional regulator from Streptomyces coelicolor (151 aa) fasta scores; opt: 184, z-score: 242.7, E(): 4.1e-06, 35.1% identity in 111 aa overlap. Contains Pfam match to entry PF01047 MarR, MarR family.
  
  
 0.691
SCO2398
SC4A7.26, possible marR-family transcriptonal regulator, len: 151 aa; similar to TR:Q9WZS3 (EMBL:AE001749) Thermotoga maritima transcriptional regulator, putative, marR family TM0816, 142 aa; fasta scores: opt: 167 z-score: 210.9 E(): 0.00023; 31.7% identity in 139 aa overlap. Contains Pfam match to entry PF01047 MarR, MarR family.
      
 0.646
SCO7708
SCBAC12C8.09c, conserved hypothetical protein, len: 216aa: similar to many eg. TR:O86609 (EMBL:AL031155) hypothetical protein from Streptomyces coelicolor (211 aa) fasta scores; opt: 764, Z-score: 865.8, 54.673% identity (55.981% ungapped) in 214 aa overlap.
       0.559
SCO3124
Ribosomal L25p family protein; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
   
  
 0.529
SCO7710
Putative phosphotransferase; SC8D11.01, unknown (fragment), len: >37 aa; SCBAC12C8.11, possible phosphotransferase, len: 248 aa: similar to SW:P18623 (VPH_STRVI) viomycin resistance phosphotransferase Vph from Streptomyces vinaceus (287 aa) fasta scores; opt: 17,3 Z-score: 197.2, 31.527% identity (37.870% ungapped) in 203 aa overlap.
       0.515
SCO7425
SC6D11.21, possible multidrug-efflux transporter protein, len: 577 aa. Highly similar to several including: Streptomyces virginiae TR:Q9XE01(EMBL:AB019519) virginiamycin S resistance protein, VarS (518 aa), fasta scores opt: 322 z-score: 328.6 E(): 7e-11 25.7% identity in 536 aa overlap and Deinococcus radiodurans TR:AAF11851(EMBL:AE002062) multidrug-efflux transporter, putative (410 aa), fasta scores opt: 937 z-score: 945.6 E(): 0 41.3% identity in 395 aa overlap. Contains a Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter and multiple possible membrane spanning hyd [...]
     
 0.500
SCO1934
Putative cytochrome oxidase assembly factor; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
   
  
 0.493
SCO0337
SCF12.16, probable transcriptional regulator, len: 188 aa; similar to many transcriptional regulators from Streptomyces spp. e.g. SW:TCMR_STRGA tetracenomycin C transcriptional repressor from Streptomyces glaucescens (226 aa) fasta scores; opt: 152, z-score: 176.0, E(): 0.019, 28.1% identity in 203 aa overlap. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family and a possible helix-turn-helix motif (+3.98 SD) 29-50aa.
  
    0.462
SCO0430
SCF51A.08, possible tetR family transcriptional regulator, len: 227 aa. Similar to several putative regulators e.g. Streptomyces coelicolor TR:CAB46405 (EMBL; AL096743) putative transcriptional regulator SCI7.22c (202 aa), fasta scores opt: 428 z-score: 495.6 E(): 3e-20 41.1% identity in 202 aa overlap. Contains a Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family and a possible helix-turn-helix motif between residues 71..92 (+3.86 SD).
  
   
 0.452
SCO0508
SCF6.04, possible tetR family transcriptional regulator, len: 180 aa. Similar to many e.g. Streptomyces glaucescens SW:TCMR_STRGA (EMBL:M80674) tetracenomycin C transcriptional repressor (226 aa), fasta scores opt: 225 z-score: 288.9 E(): 1e-08 34.5% identity in 174 aa overlap. Contains a Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family with the possible helix-turn-helix motif between residues 13..34 (+3.92 SD).
  
  
 0.442
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.