STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO7786Hypothetical protein; SC5E9.34c, unknown, len: 195 aa; regions of weak similarity to transposases eg. TR:Q9RBZ3 (EMBL:AF169828) from Pseudomonas syringae (pv. glycinea) (357 aa) fasta scores; opt: 158, z-score: 201.5, E(): 0.00093, 26.7% identity in 135 aa overlap. (195 aa)    
Predicted Functional Partners:
SCO3308
SCE68.06c, probable DNA-binding protein, len: 464 aa; similar to TR:Q9AK04 (EMBL:AL512944) Streptomyces coelicolor hypothetical protein SC8D11.15c, 471 aa; fasta scores: opt: 428 Z-score: 331.6 E(): 7.7e-11; 40.377% identity in 478 aa overlap; probable CDS suggested by positional base preference, GC frame analysis and amino acid composition. Contains a hydrophobic, possible membrane-spanning region, followed by a low-complexity proline- and serine-rich region from aa 210 to 250 approx. Contains probable helix-turn-helix motif at aa 20-41 (Score 1605, +4.65 SD).
  
     0.634
SCO3291
SCE15.08, possible regulatory protein, len: 477 aa; N-terminal region similar to others from Actinomycetes eg. SW:DNRI_STRPE regulatory protein from Streptomyces peucetius (272 aa) fasta scores; opt: 143, z-score: 162.9, E(): 0.092, (27.8% identity in 241 aa overlap).
  
     0.610
SCO7647
SC10F4.20, probable calcium binding protein, len: 179 aa; similar to SW:CBP_SACER (EMBL:M29700) Saccharopolyspora erythraea calerythrin (calcium-binding protein), 177 aa; fasta scores: opt: 216 z-score: 256.4 E(): 9.6e-07; 25.5% identity in 165 aa overlap. Contains 3x Pfam matches to entry PF00036 efhand, EF hand and 2x matches to Prosite entry PS00018 EF-hand calcium-binding domain.
  
     0.577
SCO7787
Hypothetical protein; SC5E9.35c, unknown, len: 122 aa.
 
     0.537
SCO1582
SCI35.04c, ATP/GTP binding protein, len: 174 aa; similar to TMRB_BACSU tunicamycin resistance protein (197 aa), fasta scores; opt: 282 z-score: 488.2 E(): 6.1e-20, 39.5% identity in 119 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop).
  
     0.469
SCO6336
Hypothetical protein SC3A7.04; SC3A7.04, questionable ORF, len: 384 aa; this ORF is not predicted as coding by positional base preference.
  
    0.451
SCO7724
SC8D11.15c, hypothetical protein, len: 471 aa; similar to TR:Q9WX25 (EMBL:AL079345) Streptomyces coelicolor putative membrane protein SCE68.06c, 464 aa; fasta scores: opt: 428 z-score: 361.4 E(): 1.4e-12; 40.4% identity in 478 aa overlap.
  
     0.439
SCO0528
SCF11.08, possible lipoprotein, len: 261 aa; similar to various hypothetical proteins, e.g. TR:O07236 (EMBL:Z96800) Mycobacterium tuberculosis hypothetical 22.5 KD protein, 218 aa; fasta scores: opt: 157 z-score: 172.7 E(): 0.03; 25.3% identity in 194 aa overlap. Contains a Prosite match correctly situated to entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains probable N-terminal signal sequence.
  
     0.434
SCP1.34
SCP1.34, possible conserved integral membrane protein, len: 312aa; similar to many from Streptomyces coelicolor eg. TR:O69922 (EMBL:AL023861) putative integral membrane protein (367 aa) fasta scores; opt: 613, z-score: 713.6, E(): 2.8e-32, 44.6% identity in 222 aa overlap. Contains multiple possible membrane-spanning hydrophobic regions.
  
    0.408
SCO4258
SCD8A.31, possible hydrolytic protein, len: 485 aa; similar to TR:Q9ZBF7 (EMBL:AL035206) Streptomyces coelicolor putative hydrolytic protein SC9B5.23c, 464 aa; fasta scores: opt: 1832 z-score: 1766.1 E(): 0; 66.1% identity in 492 aa overlap. Contains possible hydrophobic membrane spanning region.
  
     0.403
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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