STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCP1.95Putative regulatory protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (102 aa)    
Predicted Functional Partners:
SCO5601
Conserved hypothetical protein; SC2E1.18, unknown, len: 102 aa; highly similar to M. tuberculosis hypothetical protein YX32_MYCTU MTCY274.32c (101 aa), fasta scores; opt: 515 z-score: 1085.2 E(): 0, 75.0% identity in 100 aa overlap.
  
     0.772
SCO1381
SC1A8A.01c, partial CDS, hypothetical protein, len: >183aa; similar to SW:Q50603 (Y0DD_MYCTU) hypothetical protein from Mycobacterium tuberculosis (225 aa) fasta scores; opt: 641, z-score: 633.8, E(): 7.1e-28, 64.7% identity in 150 aa overlap. Note possible alternative translational start sites downstream; SC10A9.23c, conserved hypothetical protein (fragment), len: >78 aa; similar to SW:YI30_MYCTU (EMBL:Z78020) Mycobacterium tuberculosis hypothetical 24.0 kDa protein MTCY1A11.13c, 225 aa; fasta scores: opt: 269 z-score: 377.2 E(): 1.4e-13; 56.0% identity in 75 aa overlap.
  
     0.771
SCO2947
SCE59.06c, hypothetical protein, len: 97 aa; similar to TR:O07209 (EMBL:Z96072) Mycobacterium tuberculosis hypothetical 9.0 kD protein MTCY05A6.29, len: 82 aa; fasta scores: opt: 200 z-score: 268.5 E(): 1.5e-07; 51.6% identity in 62 aa overlap.
  
     0.770
SCO2683
SCC61A.04c, possible single-strand DNA-binding protein, len: 156 aa; similar to many eg. SW:P71711 (SSB_MYCTU) single-strand binding protein from Mycobacterium tuberculosis (164 aa) fasta scores; opt: 259, z-score: 301.8, E(): 2.4e-09, 35.5% identity in 141 aa overlap and TR:Q9X8U3 (EMBL:AL049826) putative single-strand binding protein from Streptomyces coelicolor (199 aa) fasta scores; opt: 261, z-score: 302.7, E(): 2.1e-09, 42.5% identity in 120 aa overlap. Contains Pfam match to entry PF00436 SSB, Single-strand binding protein family.
  
     0.765
SCO1944
Protein-export membrane protein; Involved in protein export. Participates in an early event of protein translocation (By similarity); Belongs to the SecG family.
  
     0.759
SCO1478
Putative DNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).
  
     0.750
SCO5388
Conserved hypothetical protein; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family.
  
     0.748
SCO4470
SCD65.13, probable phosphoglycerate mutase, len: 233 aa; similar to SW:PMG2_ECOLI (EMBL:M97495) Escherichia coli probable phosphoglycerate mutase 2 (EC 5.4.2.1) GpmB, 215 aa; fasta scores: opt: 182 z-score: 227.1 E(): 3.5e-05; 26.5% identity in 215 aa overlap. Contains Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase family.
  
     0.719
SCO5199
2SC3B6.23c, conserved hypothetical protein, len: 487 aa; similar to TR:O53341 (EMBL:AL021646) Mycobacterium tuberculosis hypothetical 49.4 kD protein, 472 aa; fasta scores: opt: 1382 z-score: 1331.8 E(): 0; 46.2% identity in 489 aa overlap.
  
     0.685
SCO3872
SCH18.09c, possible integral membrane protein, len: 185 aa; similar to TR:P71575 (EMBL:Z80233) Mycobacterium tuberculosis hypothetical 31.3 kD protein CY10H4.05, 304 aa; fasta scores: opt: 315 z-score: 339.9 E(): 1.8e-11; 32.8% identity in 195 aa overlap. Contains possible hydrophobic membrane spanning regions.
  
     0.670
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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