STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCP1.162cSCP1.162c, possible oxidoreductase subunit, len: 65aa; similar to the extreme C-terminus of many glycerol-3-phosphate dehydrogenases eg. TR:Q9ZBS0 (EMBL:AL034447) glycerol-3-phosphate dehydrogenase from Streptomyces coelicolor (336 aa) fasta scores; opt: 302, z-score: 432.6, E(): 1.3e-16, 76.9% identity in 65 aa overlap. Also similar to neighbouring CDS SCP1.162c fasta scores; opt: 238, z-score: 294.0, E(): 7.6e-12, 50.7% identity in 75 aa overlap. (65 aa)    
Predicted Functional Partners:
SCO2685
SCC61A.06c, possible ATP-binding protein, len: 535aa; no significant database similarities. Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). Note possible alternative downstream translational start sites.
 
  
 0.730
SCO1758
Putative GTP binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
  
  
 0.705
SCO3337
Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
   
 
 0.603
SCO5802
SC4H2.23, probable ATP-dependent helicase, len: 664 aa; similar to e.g. DING_ECOLI P27296 probable ATP-dependent helicase dinG (716 aa), fasta scores opt: 272 z-score: 409.8 E(): 1.3e-15, 26.5% identity in 686 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop).
  
    0.592
SCO6205
SC2G5.26c, probable dehydrogenase, len: 296aa; similar to many eg. TR:D1035162 (EMBL:AB015439) D-threonine dehydrogenase (292 aa) fasta scores; opt: 628, z-score:702.7, E(): 7.4e-32, (37.6% identity in 290 aa overlap).
     
 0.564
SCO2034
Putative prolipoprotein diacyleglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family.
  
    0.535
SCO7822
Probable prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.; Belongs to the Lgt family.
  
    0.535
SCO5514
Acetolactate synthase small subunit; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
      
 0.516
SCO6732
SC5F2A.15, possible fatty acid oxidative multifunctional enzyme, len: 726aa; similar to SW:FAOB_PSEFR fatty oxidation complex alpha subunit from Pseudomonas fragi (715 aa) fasta scores; opt: 1174, z-score: 1211.3, E(): 0, (33.2% identity in 717 aa overlap). Also similar to TR:O53872 (EMBL:AL022004) hypothetical protein from Mycobacterium tuberculosis (720 aa) fasta scores; opt: 3034, z-score: 3128.4, E(): 0, (64.3% identity in 717 aa overlap). Also similar to SC6A5.38 (EMBL:AL049485) possible fatty oxidation protein from Streptomyces coelicolor (733 aa) fasta scores; opt: 4069, z-score [...]
  
  
 0.471
SCO6789
SC6A5.38, possible fatty oxidation protein, len: 733aa; similar to many eg. SW:FADB_ECOLI FadB, a multifunctional protein from the Escherichia coli fadBA operon, encoding the fatty acid-oxidizing multienzyme complex (729 aa) fasta scores; opt: 1119, z-score: 1146.7, E(): 0, (32.3% identity in 691 aa overlap). Contains Pfam matches to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family and entry PF00725 3HCDH, 3-hydroxyacyl-CoA dehydrogenase and a Prosite match to PS00923 Aspartate and glutamate racemases signature 1.
  
  
 0.471
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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