STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCP1.310cSCP1.310c, possible oxidoreductase, len: 338aa; similar to many eg. TR:Q9RJW9 (EMBL:AL133210) putative reductase (fragment) from Streptomyces coelicolor (311 aa) fasta scores; opt: 795, z-score: 852.7, E(): 0, 44.0% identity in 293 aa overlap and SW:O82864 (AHPF_PSEPU) alkyl hydroperoxide reductase subunit from Pseudomonas putida (520 aa) fasta scores; opt: 301, z-score: 325.3, E(): 1.2e-10, 25.6% identity in 301 aa overlap. (338 aa)    
Predicted Functional Partners:
SCO5178
2SC3B6.02, possible sulfurylase, len: 392 aa; similar to TR:AAF33130 (EMBL:AF196567) Pseudomonas stutzeri putative sulfurylase, 391 aa; fasta scores: opt: 1433 z-score: 1624.0 E(): 0; 56.2% identity in 395 aa overlap and to SW:MOEB_ECOLI (EMBL:M21151) Escherichia coli molybdopterin biosynthesis MoeB protein, 249 aa; blastp socres: Score = 526 (185.2 bits), Expect = 1.1e-50, P = 1.1e-5, Identities = 106/249 (42%), Positives = 156/249 (62%). Contains Pfam match to entry PF00899 ThiF_family, ThiF family and PF00581 Rhodanese, Rhodanese-like domain.
  
  
 0.548
SCP1.309c
SCP1.309c, possible integral membrane efflux protein, len: 545aa; similar to many eg. TR:Q9XE01 (EMBL:AB019519) VarS virginiamycin S resistance protein from Streptomyces virginiae (518 aa) fasta scores; opt: 1001, z-score: 1036.6, E(): 0, 36.8% identity in 522 aa overlap and TR:O54186 (EMBL:AL021411) putative transport protein from Streptomyces coelicolor (533 aa) fasta scores; opt: 2830, z-score: 2920.7, E(): 0, 79.5% identity in 533 aa overlap. Contains multiple possible membrane-spanning hydrophobic regions.
       0.535
SCO5094
SCBAC28G1.20c, ORF8, putative methyltransferase, len: 208 aa; identical to previously sequenced TR:Q9X9V1 (EMBL:Y18817) Streptomyces coelicolor A3(2) putative methyltransferase ORF8, 208 aa.
 
  
 0.533
SCO5032
SCK7.05c, ahpC, alkyl hydroperoxide reductase, len:184 aa; identical to previously seqeunced TR:Q9RN72 (EMBL:AF186371) Streptomyces coelicolor A3(2) AhpC, 184 aa. Contains Pfam match to entry PF00578 AhpC-TSA, AhpC/TSA family.
  
 
 0.515
SCO0142
Conserved hypothetical protein SCJ33.06c; SCJ33.06c, unknown, len: 601 aa. Similar to the C-terminus of Mycobacterium tuberculosis hypothetical proteins SW:YS74_MYCTU (EMBL; Z74024) (695 aa), fasta scores opt: 331 z-score: 375.0 E(): 1.6e-13 30.3% identity in 185 aa overlap and SW:YX05_MYCTU (EMBL; Z74024) (695 aa), fasta scores opt: 331 z-score: 375.0 E(): 1.6e-13 30.3% identity in 185 aa overlap. Contains 5x Pfam match to entry PF01436 NHL, NHL repeat and possible membrane spanning hydrophobic domains.
  
 
 0.500
SCO0885
Thioredoxin; Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity).
  
 
 0.497
SCO0376
SCF62.02, possible transcriptional regulator, len: 200 aa. Similar to several proteins of undefined function from Streptomyces sp. e.g. Streptomyces coelicolor TR:CAB51134 (EMBL; Y18817) hypothetical 20.6 KD protein (190 aa), fasta scores opt: 352 z-score: 424.9 E(): 2.6e-16 37.0% identity in 189 aa overlap. Contains a Pfam match to entry PF01381 HTH_3, Helix-turn-helix between residues 29..50 (+5.17 SD).
 
    0.483
SCO5193
2SC3B6.17c, possible secreted protein, len: 442 aa; similar to TR:O53342 (EMBL:AL021646) Mycobacterium tuberculosis hypothetical 31.6 kD protein MTV014.40, 299 aa; fasta scores: opt: 233 z-score: 233.2 E(): 1.6e-05; 29.9% identity in 261 aa overlap. Contains possible N-terminal region signal peptide sequence.
  
  
 0.475
SCO1084
SCG22.30c, possible thioredoxin, len: 126 aa; similar to TR:Q50039 (EMBL:U15182) Mycobacterium leprae ThiX, 172 aa; fasta scores: opt: 253 z-score: 318.8 E(): 2.8e-10; 40.6% identity in 101 aa overlap, 172 and to SW:THIO_MYCSM (EMBL:AF023161) Mycobacterium smegmatis thioredoxin TrxA, 112 aa; fasta scores: opt: 147 z-score: 193.6 E(): 0.0026; 28.4% identity in 109 aa overlap. Contains match to Prosite entry PS00194 Thioredoxin family active site.
  
 
 0.450
SCO3889
Thioredoxin; Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Stimulates complex formation between sigma factor SigR and its cognate anti-sigma factor RsrA probably by reducing RsrA.
  
 
 0.418
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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