STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCP1.320cSCP1.320c, possible conserved integral membrane protein, len: 312aa; similar to many from Streptomyces coelicolor eg. TR:O69922 (EMBL:AL023861) putative integral membrane protein (367 aa) fasta scores; opt: 613, z-score: 713.6, E(): 2.8e-32, 44.6% identity in 222 aa overlap. Contains multiple possible membrane-spanning hydrophobic regions. (312 aa)    
Predicted Functional Partners:
SCO4695
SCD31.20, hypothetical protein, len: 181 aa; similar to C-terminal part of many hypothetical proteins, e.g. TR:O54162 (EMBL:AL021411) Streptomyces coelicolor hypothetical 40.9 kD protein SC7H1.03c, 391 aa; fasta scores: opt: 594 z-score: 691.0 E(): 4.7e-31; 53.5% identity in 185 aa overlap.
  
     0.747
SCO3548
SCH5.11c, probable anti-sigma factor, len: 143 aa; similar to many e.g. SW:RSBW_BACSU RsbW, anti-sigma B factor from Bacillus subtilis (160 aa) fasta scores; opt: 153, z-score: 198.9, E(): 0.00089, (28.7% identity in 136 aa overlap) and SW:SP22_BACSU SpoIIAB, anti-sigma F factor, sporulation protein, from Bacillus subtilis (146 aa) fasta scores; opt: 125, z-score: 165.8, E(): 0.063, (29.2% identity in 137 aa overlap).
  
     0.665
SCO3905
SCH24.27c, putative membrane protein, len: 101 aa; unknown function, probable CDS suggested by positional base preference, GC frame analysis and amino acid composition. Contains possible hydrophobic membrane spanning regions.
  
     0.653
SCO1784
SCI51.24, hypothetical protein, len: 115 aa; unknown function, probable CDS suggested by GC frameplot, positional base preference and amino acid composition.
  
     0.618
SCO3423
SCE9.30, possible regulator, len: 154 aa; similar to TR:Q53897 (EMBL:X60316), AbaA, Streptomyces coelicolor ORFA from AbaA regulatory locus for antibiotic production (192 aa), fasta scores; opt: 278 z-score: 352.7 E(): 2.5e-12, 39.9% identity in 148 aa overlap. Also similar to several S. coelicolor hypothetical proteins including the N-terminus of TR:O86807 (EMBL:AL031031), SC7C7.02c, possible regulatory protein (916 aa) (35.0% identity in 137 aa overlap). Contains TTA (leucine) codon, possible target for bldA regulation, near N-terminus.
  
     0.577
SCP1.96
Hypothetical protein; SCP1.96, unknown, len: 79aa; weakly similar to TR:Q54341 (EMBL:M18244) hypothetical protein from Streptomyces limosus (Streptomyces albidoflavus) (57 aa) fasta scores; opt: 82, z-score: 132.4, E(): 6.6, 41.7% identity in 48 aa overlap.
  
     0.554
SCO5987
SCBAC16H6.21c, conserved hypothetical protein, len: 69aa: similar to two others in Streptomyces coelicolor - TR:Q9AK87 (EMBL:AL583943) SC10A9.17 (chromosomal) (67 aa) fasta scores; opt: 276, Z-score: 372.9, 60.317% identity (63.333% ungapped) in 63 aa overlap and TR:Q9AD54 (EMBL:AL590463) SCP1.96 (plasmid) (79 aa) fasta scores; opt: 274, Z-score: 369.2, 59.322% identity (61.404% ungapped) in 59 aa overlap.
  
     0.549
SCO6156
SC1A9.20, possible regulatory protein, len: 135aa; similar to TR:O69204 (EMBL:U33059) hypothetical protein from Amycolatopsis mediterranei S699 (144 aa) fasta scores; opt:225, z-score:335.1. E(): 2.2e-11, (41.7% identity in 115 aa overlap). Also similar to TR:Q53897 (EMBL:X60316) AbaA regulatory locus for antibiotic production in Streptomyces coelicolor (192 aa), fasta scores; opt: 155, z-score: 284.6, E(): 1.4e-08, (33.3% identity in 120 aa overlap).
  
     0.538
SCO4039
Hypothetical protein 2SCD60.05c; 2SCD60.05c, unknown, len: 182 aa.
  
     0.534
SCO5978
SCBAC16H6.13c, conserved hypothetical protein, len: 161aa: similar to many others in Streptomyces coelicolor eg. TR:Q9X7Q5 (EMBL:AL049587) hypothetical protein SC5F2A.32 (161 aa) fasta scores; opt: 222, Z-score: 255.7, 32.515% identity (36.054% ungapped) in 163 aa overlap. Also similar to TR:O69204 (EMBL:U33059) hypothetical protein from Actinosynnema pretiosum (subsp. auranticum) (144 aa) fasta scores; opt: 227, Z-score: 261.8, 39.735% identity (45.113% ungapped) in 151 aa overlap. Contains Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase.
  
     0.527
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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