STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ifngr1Interferon-gamma receptor alpha chain. (471 aa)    
Predicted Functional Partners:
Ifngr2
Interferon-gamma receptor beta chain.
   
 0.998
Ifng
Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
    
 0.998
Jak1
Tyrosine-protein kinase.
   
 0.995
Stat1
Signal transducer and activator of transcription.
   
 0.992
Jak2
Tyrosine-protein kinase.
   
 0.990
Tyk2
Tyrosine-protein kinase.
   
 0.978
Ifnar1
Interferon-alpha/beta receptor alpha chain.
   
 0.977
Jak3
Tyrosine-protein kinase JAK3.
   
 0.960
I79_000823
Interferon-alpha/beta receptor beta chain.
   
 
 0.944
Pik3r1
Phosphatidylinositol 3-kinase regulatory subunit alpha.
     
 0.912
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.