STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ItchE3 ubiquitin-protein ligase. (851 aa)    
Predicted Functional Partners:
Traf6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.968
Cflar
CASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family.
    
 0.967
Numb
Protein numb-like; Belongs to the histone H2A family.
    
 0.941
Mdm2
E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.
    
 0.933
Ubc
Ubiquitin.
    
 0.927
Cblb
E3 ubiquitin-protein ligase CBL-B.
    
 0.926
Mapk9
Mitogen-activated protein kinase 9.
    
 0.913
Rnf41
E3 ubiquitin-protein ligase NRDP1.
    
 0.913
Smurf1
E3 ubiquitin-protein ligase SMURF1.
     
0.901
Txnip
Thioredoxin-interacting protein.
    
 
 0.875
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.