STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Fgf21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)    
Predicted Functional Partners:
Klb
Beta-klotho; Belongs to the glycosyl hydrolase 1 family.
    
 0.982
Fgfr2
Fibroblast growth factor receptor 2.
    
 0.979
Fgfr3
Fibroblast growth factor receptor 3.
    
 0.931
Kl
Klotho.
    
 0.896
Pdgfra
Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.
    
 0.808
I79_004031
Fibroblast growth factor receptor.
    
 0.797
Igf1r
Insulin-like growth factor 1 receptor.
    
 0.784
Ins
Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.
   
  
 0.779
Kit
Mast/stem cell growth factor receptor.
    
 0.772
Pdgfrb
Beta-type platelet-derived growth factor receptor.
    
 0.767
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.