STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Traf2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)    
Predicted Functional Partners:
Tradd
Tumor necrosis factor receptor type 1-associated DEATH domain protein.
    
 0.999
Tnfrsf1a
Tumor necrosis factor receptor superfamily member 1A.
    
 0.998
Traf1
TNF receptor-associated factor 1.
   
0.997
Ripk1
Receptor-interacting serine/threonine-protein kinase 1.
   
 0.996
Tnfrsf1b
Tumor necrosis factor receptor superfamily member 1B.
   
 0.991
Traf6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
0.990
Fadd
FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
   
 0.989
Chuk
Inhibitor of nuclear factor kappa-B kinase subunit alpha.
   
 0.983
Ltbr
Tumor necrosis factor receptor superfamily member 3.
    
 0.982
Traf5
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
0.982
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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