STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Crtc3CREB-regulated transcription coactivator 3. (175 aa)    
Predicted Functional Partners:
I79_023247
CREB-regulated transcription coactivator 3.
 
     0.935
Crtc1
CREB-regulated transcription coactivator 1.
     
 0.911
Slc6a11
Sodium-and chloride-dependent GABA transporter 3.
   
  
 0.759
Elavl2
ELAV-like protein; Belongs to the RRM elav family.
      
 0.702
Sik3
Serine/threonine-protein kinase QSK.
    
 
 0.676
I79_014474
Cyclic AMP-responsive element-binding protein 1.
    
 0.645
Pde4d
Phosphodiesterase.
   
  
 0.582
Atf1
Cyclic AMP-dependent transcription factor ATF-1-like protein.
    
 0.569
Mbtps2
Membrane-bound transcription factor site-2 protease.
     
 0.507
MBTPS1
Membrane-bound transcription factor site-1 protease; Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysos [...]
   
 
 0.478
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.