SFF08809.1 protein (Thermoflexibacter ruber)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

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Score

SFF08809.1

Iron complex outermembrane recepter protein. (813 aa)

Predicted Functional Partners:

SFF08823.1

0.812

SFF13413.1

0.650

SFE82008.1

0.623

SFF23192.1

0.611

SFE67537.1

0.599

SFF52816.1

0.542

SFF41883.1

0.501

SFE96782.1

0.435

SFE84338.1

0.418

SFE70919.1

0.404

Your Current Organism:

Thermoflexibacter ruber

NCBI taxonomy Id: 1003
Other names: ATCC 23103, DSM 9560, Flexibacter ruber, IFO 16677, LMG 13857, LMG:13857, NBRC 16677, T. ruber, strain GEY

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SFE67537.1	SFF08809.1	SAMN04488541_100513	SAMN04488541_101566	Ferric-dicitrate binding protein FerR, regulates iron transport through sigma-19.	Iron complex outermembrane recepter protein.	0.599
SFE67537.1	SFF08823.1	SAMN04488541_100513	SAMN04488541_101567	Ferric-dicitrate binding protein FerR, regulates iron transport through sigma-19.	Uncharacterized iron-regulated membrane protein.	0.455
SFE70919.1	SFE84338.1	SAMN04488541_1005124	SAMN04488541_100822	Hypothetical protein.	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region.	0.442
SFE70919.1	SFF08809.1	SAMN04488541_1005124	SAMN04488541_101566	Hypothetical protein.	Iron complex outermembrane recepter protein.	0.404
SFE82008.1	SFF08809.1	SAMN04488541_100795	SAMN04488541_101566	Ferric-dicitrate binding protein FerR, regulates iron transport through sigma-19.	Iron complex outermembrane recepter protein.	0.623
SFE82008.1	SFF08823.1	SAMN04488541_100795	SAMN04488541_101567	Ferric-dicitrate binding protein FerR, regulates iron transport through sigma-19.	Uncharacterized iron-regulated membrane protein.	0.431
SFE84338.1	SFE70919.1	SAMN04488541_100822	SAMN04488541_1005124	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region.	Hypothetical protein.	0.442
SFE84338.1	SFF08809.1	SAMN04488541_100822	SAMN04488541_101566	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region.	Iron complex outermembrane recepter protein.	0.418
SFE96782.1	SFF08809.1	SAMN04488541_101163	SAMN04488541_101566	Iron complex outermembrane recepter protein.	Iron complex outermembrane recepter protein.	0.435
SFF08809.1	SFE67537.1	SAMN04488541_101566	SAMN04488541_100513	Iron complex outermembrane recepter protein.	Ferric-dicitrate binding protein FerR, regulates iron transport through sigma-19.	0.599
SFF08809.1	SFE70919.1	SAMN04488541_101566	SAMN04488541_1005124	Iron complex outermembrane recepter protein.	Hypothetical protein.	0.404
SFF08809.1	SFE82008.1	SAMN04488541_101566	SAMN04488541_100795	Iron complex outermembrane recepter protein.	Ferric-dicitrate binding protein FerR, regulates iron transport through sigma-19.	0.623
SFF08809.1	SFE84338.1	SAMN04488541_101566	SAMN04488541_100822	Iron complex outermembrane recepter protein.	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region.	0.418
SFF08809.1	SFE96782.1	SAMN04488541_101566	SAMN04488541_101163	Iron complex outermembrane recepter protein.	Iron complex outermembrane recepter protein.	0.435
SFF08809.1	SFF08823.1	SAMN04488541_101566	SAMN04488541_101567	Iron complex outermembrane recepter protein.	Uncharacterized iron-regulated membrane protein.	0.812
SFF08809.1	SFF13413.1	SAMN04488541_101566	SAMN04488541_101715	Iron complex outermembrane recepter protein.	Ferric-dicitrate binding protein FerR, regulates iron transport through sigma-19.	0.650
SFF08809.1	SFF23192.1	SAMN04488541_101566	SAMN04488541_102124	Iron complex outermembrane recepter protein.	Ferric-dicitrate binding protein FerR, regulates iron transport through sigma-19.	0.611
SFF08809.1	SFF41883.1	SAMN04488541_101566	SAMN04488541_103257	Iron complex outermembrane recepter protein.	FecR protein.	0.501
SFF08809.1	SFF52816.1	SAMN04488541_101566	SAMN04488541_10492	Iron complex outermembrane recepter protein.	Ferric-dicitrate binding protein FerR, regulates iron transport through sigma-19.	0.542
SFF08823.1	SFE67537.1	SAMN04488541_101567	SAMN04488541_100513	Uncharacterized iron-regulated membrane protein.	Ferric-dicitrate binding protein FerR, regulates iron transport through sigma-19.	0.455

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Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.916

expected number of edges:

29

PPI enrichment p-value:

0.0016

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006544

Glycine metabolic process

4 of 8

2.2

2.29

3.30e-05

GO:0019464

Glycine decarboxylation via glycine cleavage system

3 of 4

2.37

1.76

0.00051

GO:0006189

De novo IMP biosynthetic process

3 of 14

1.83

1.39

0.0015

GO:0035999

Tetrahydrofolate interconversion

2 of 3

2.32

1.31

0.0037

GO:0009156

Ribonucleoside monophosphate biosynthetic process

4 of 37

1.53

1.29

0.0011

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016742

Hydroxymethyl-, formyl- and related transferase activity

4 of 8

2.2

2.41

1.84e-05

GO:0016741

Transferase activity, transferring one-carbon groups

5 of 61

1.41

1.36

0.00031

GO:0019238

Cyclohydrolase activity

2 of 5

2.1

0.73

0.0440

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005960

Glycine cleavage complex

2 of 3

2.32

1.22

0.0055

GO:0005829

Cytosol

7 of 303

0.86

0.71

0.0012

GO:0005737

Cytoplasm

9 of 1173

0.38

0.26

0.0472

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:31410034

(2019) Staphyloxanthin: a potential target for antivirulence therapy.

3 of 10

1.98

1.56

0.00079

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1866

Glycine catabolic process

4 of 5

2.4

2.76

5.29e-06

CL:839

De novo IMP biosynthetic process

3 of 8

2.07

1.61

0.00075

CL:834

Nucleoside monophosphate biosynthetic process, and Pyrimidine metabolism

4 of 57

1.35

0.99

0.0040

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00670

One carbon pool by folate

5 of 17

1.97

2.95

3.19e-07

map00260

Glycine, serine and threonine metabolism

4 of 46

1.44

1.37

0.00033

map00630

Glyoxylate and dicarboxylate metabolism

4 of 49

1.41

1.35

0.00033

map01200

Carbon metabolism

6 of 114

1.22

1.33

3.39e-05

map01110

Biosynthesis of secondary metabolites

8 of 436

0.76

0.66

0.00029

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005960

Glycine cleavage complex

2 of 3

2.32

0.88

0.0239

GOCC:0005737

Cytoplasm

9 of 946

0.48

0.31

0.0352

GOCC:0005622

Intracellular

10 of 1285

0.39

0.28

0.0352

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0658

Purine biosynthesis

4 of 17

1.87

1.96

6.97e-05

KW-0554

One-carbon metabolism

2 of 5

2.1

0.9

0.0210

KW-0511

Multifunctional enzyme

2 of 10

1.8

0.71

0.0436

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