node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFE55599.1 | SFF11941.1 | SAMN04488541_100317 | SAMN04488541_101673 | Cytochrome P450. | Protein of unknown function. | 0.808 |
SFE55599.1 | SFF32743.1 | SAMN04488541_100317 | SAMN04488541_102615 | Cytochrome P450. | ring-1,2-phenylacetyl-CoA epoxidase subunit PaaE. | 0.979 |
SFE55599.1 | kmo | SAMN04488541_100317 | SAMN04488541_103235 | Cytochrome P450. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid; Belongs to the aromatic-ring hydroxylase family. KMO subfamily. | 0.819 |
SFF11941.1 | SFE55599.1 | SAMN04488541_101673 | SAMN04488541_100317 | Protein of unknown function. | Cytochrome P450. | 0.808 |
SFF11941.1 | kmo | SAMN04488541_101673 | SAMN04488541_103235 | Protein of unknown function. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid; Belongs to the aromatic-ring hydroxylase family. KMO subfamily. | 0.759 |
SFF31905.1 | SFF32743.1 | SAMN04488541_102559 | SAMN04488541_102615 | Aminocarboxymuconate-semialdehyde decarboxylase. | ring-1,2-phenylacetyl-CoA epoxidase subunit PaaE. | 0.720 |
SFF31905.1 | kmo | SAMN04488541_102559 | SAMN04488541_103235 | Aminocarboxymuconate-semialdehyde decarboxylase. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid; Belongs to the aromatic-ring hydroxylase family. KMO subfamily. | 0.805 |
SFF31905.1 | kynU | SAMN04488541_102559 | SAMN04488541_102420 | Aminocarboxymuconate-semialdehyde decarboxylase. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. | 0.773 |
SFF31905.1 | nbaC | SAMN04488541_102559 | SAMN04488541_101152 | Aminocarboxymuconate-semialdehyde decarboxylase. | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. | 0.900 |
SFF32743.1 | SFE55599.1 | SAMN04488541_102615 | SAMN04488541_100317 | ring-1,2-phenylacetyl-CoA epoxidase subunit PaaE. | Cytochrome P450. | 0.979 |
SFF32743.1 | SFF31905.1 | SAMN04488541_102615 | SAMN04488541_102559 | ring-1,2-phenylacetyl-CoA epoxidase subunit PaaE. | Aminocarboxymuconate-semialdehyde decarboxylase. | 0.720 |
SFF32743.1 | kmo | SAMN04488541_102615 | SAMN04488541_103235 | ring-1,2-phenylacetyl-CoA epoxidase subunit PaaE. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid; Belongs to the aromatic-ring hydroxylase family. KMO subfamily. | 0.771 |
SFF37936.1 | kmo | SAMN04488541_102932 | SAMN04488541_103235 | Tryptophan 2,3-dioxygenase apoenzyme. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid; Belongs to the aromatic-ring hydroxylase family. KMO subfamily. | 0.774 |
SFF37936.1 | kynU | SAMN04488541_102932 | SAMN04488541_102420 | Tryptophan 2,3-dioxygenase apoenzyme. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. | 0.967 |
SFF37936.1 | nbaC | SAMN04488541_102932 | SAMN04488541_101152 | Tryptophan 2,3-dioxygenase apoenzyme. | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. | 0.567 |
SFF41543.1 | SFF41575.1 | SAMN04488541_103234 | SAMN04488541_103236 | Glycerate kinase; Belongs to the glycerate kinase type-1 family. | Putative Holin-X, holin superfamily III. | 0.726 |
SFF41543.1 | kmo | SAMN04488541_103234 | SAMN04488541_103235 | Glycerate kinase; Belongs to the glycerate kinase type-1 family. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid; Belongs to the aromatic-ring hydroxylase family. KMO subfamily. | 0.737 |
SFF41575.1 | SFF41543.1 | SAMN04488541_103236 | SAMN04488541_103234 | Putative Holin-X, holin superfamily III. | Glycerate kinase; Belongs to the glycerate kinase type-1 family. | 0.726 |
SFF41575.1 | kmo | SAMN04488541_103236 | SAMN04488541_103235 | Putative Holin-X, holin superfamily III. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid; Belongs to the aromatic-ring hydroxylase family. KMO subfamily. | 0.762 |
SFF46002.1 | kmo | SAMN04488541_103710 | SAMN04488541_103235 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid; Belongs to the aromatic-ring hydroxylase family. KMO subfamily. | 0.737 |