node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFF05026.1 | SFF40556.1 | SAMN04488541_101417 | SAMN04488541_103151 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. | Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin). | 0.778 |
SFF05026.1 | SFF57127.1 | SAMN04488541_101417 | SAMN04488541_106111 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | 0.524 |
SFF11164.1 | SFF41856.1 | SAMN04488541_101637 | SAMN04488541_103255 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | PLD-like domain-containing protein. | 0.907 |
SFF11164.1 | SFF53748.1 | SAMN04488541_101637 | SAMN04488541_105113 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.787 |
SFF11164.1 | SFF57127.1 | SAMN04488541_101637 | SAMN04488541_106111 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | 0.653 |
SFF11164.1 | dut | SAMN04488541_101637 | SAMN04488541_100745 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.786 |
SFF11164.1 | thyA | SAMN04488541_101637 | SAMN04488541_105111 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.790 |
SFF28251.1 | SFF57127.1 | SAMN04488541_102369 | SAMN04488541_106111 | Putative holliday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | 0.740 |
SFF40556.1 | SFF05026.1 | SAMN04488541_103151 | SAMN04488541_101417 | Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin). | Glutathione peroxidase; Belongs to the glutathione peroxidase family. | 0.778 |
SFF40556.1 | SFF41856.1 | SAMN04488541_103151 | SAMN04488541_103255 | Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin). | PLD-like domain-containing protein. | 0.443 |
SFF40556.1 | SFF53748.1 | SAMN04488541_103151 | SAMN04488541_105113 | Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin). | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.551 |
SFF40556.1 | SFF57127.1 | SAMN04488541_103151 | SAMN04488541_106111 | Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin). | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | 0.563 |
SFF40556.1 | ndk | SAMN04488541_103151 | SAMN04488541_100688 | Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin). | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.413 |
SFF41856.1 | SFF11164.1 | SAMN04488541_103255 | SAMN04488541_101637 | PLD-like domain-containing protein. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.907 |
SFF41856.1 | SFF40556.1 | SAMN04488541_103255 | SAMN04488541_103151 | PLD-like domain-containing protein. | Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin). | 0.443 |
SFF41856.1 | SFF57127.1 | SAMN04488541_103255 | SAMN04488541_106111 | PLD-like domain-containing protein. | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | 0.491 |
SFF41856.1 | gmk | SAMN04488541_103255 | SAMN04488541_102727 | PLD-like domain-containing protein. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.857 |
SFF53748.1 | SFF11164.1 | SAMN04488541_105113 | SAMN04488541_101637 | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.787 |
SFF53748.1 | SFF40556.1 | SAMN04488541_105113 | SAMN04488541_103151 | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin). | 0.551 |
SFF53748.1 | SFF57127.1 | SAMN04488541_105113 | SAMN04488541_106111 | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | 0.997 |