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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tie1Tyrosine-protein kinase receptor Tie-1. (1114 aa)    
Predicted Functional Partners:
Angpt1
Angiopoietin-1.
   
 0.943
Angpt2
Angiopoietin-2.
   
 0.943
Pdgfc
Platelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family.
    
 0.925
Vegfb
Vascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family.
    
 0.904
Angpt4
Angiopoietin-4.
   
 0.892
Pdgfb
Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.
    
 0.888
Fgf2
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.888
Vegfc
Vascular endothelial growth factor C isoform X1; Belongs to the PDGF/VEGF growth factor family.
    
 0.884
Kitl
KIT ligand.
    
 0.882
Vegfa
Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...]
    
 0.877
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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